The regulation of normal and leukemic hematopoietic stem cells by niches [0.03%]
小生境对正常和白血病造血干细胞的调控作用
Meng-Meng Huang,Jiang Zhu
Meng-Meng Huang
The origin and propagation of normal and leukemic hematopoietic cells critically depend on their interplays with the hematopoietic microenvironment (or so-called niche), which represent important biological models for understanding organoge...
Molecular regulation of lymphangiogenesis in development and tumor microenvironment [0.03%]
发育和肿瘤微环境中淋巴管发生相关的分子调控机制研究进展
Taotao Li,Jianfeng Yang,Quansheng Zhou et al.
Taotao Li et al.
A rapid progress has been made in the field of lymphatic research during the last 15 years. This includes better understanding of the cellular events and molecular players involved in the lymphatic vessel formation and remodeling in develop...
Johann Bergholz,Zhi-Xiong Xiao
Johann Bergholz
The p53-related protein p63 has pleiotropic functions, including cell proliferation, survival, apoptosis, differentiation, senescence, and aging. The p63 gene is expressed as multiple isoforms that either contain an N-terminal p53-homologou...
Zhisong Zhang,Lu-Yuan Li
Zhisong Zhang
Tumor necrosis factor superfamily-15 (TNFSF15; also known as VEGI or TL1A) is a unique cytokine that functions in the modulation of vascular homeostasis and inflammation. TNFSF15 is expressed abundantly in established vasculature but is dow...
Feng-Chun Yang,Karl Staser,D Wade Clapp
Feng-Chun Yang
Dynamic interactions between tumorigenic cells and surrounding cells, including immunomodulatory hematopoietic cells, can dictate tumor initiation, progression, and transformation. Hematopoietic-stromal interactions underpin the plexiform n...
David Tarin
David Tarin
In normal tissues and organs, the activities of the constituent cells are strictly restricted to the tasks assigned to them during development. In addition they (with the exception of leukocytes) remain inflexibly confined to their territor...
David Tarin
David Tarin
In normal tissues and organs, the activities of the constituent cells are strictly restricted to the tasks assigned to them during development. In addition they (with the exception of leukocytes) remain inflexibly confined to their territor...
Yan Wu,Limin Zheng
Yan Wu
Human tumor tissues can often be anatomically classified into areas of cancer nest, invading edge, and peritumoral stroma, each with distinct compositions and functional properties. Macrophages (Mφ) constitute a major component of the leuk...
Inflammatory immune responses in tumor microenvironment and metastasis of hepatocellular carcinoma [0.03%]
肝细胞癌肿瘤微环境中的炎症免疫反应及其转移机制研究
Lun-Xiu Qin
Lun-Xiu Qin
Metastasis is a multistage process that requires cancer cells to escape from the primary tumor, survive in the circulation, seed at distant sites and grow. Each of these processes involves rate-limiting steps that are influenced by non-mali...