Masakazu Yashiro,Kosei Hirakawa
Masakazu Yashiro
Fibroblasts play an important role in the progression, growth and spread of gastric cancers. Cancer-stroma interactions have been especially evident in the scirrhous type of gastric carcinoma. Fibroblasts are associated with the cancer prog...
Daniel L Worthley,Andrew S Giraud,Timothy C Wang
Daniel L Worthley
The normal gastrointestinal stroma consists of extra-cellular matrix and a community of stromal cells including fibroblasts, myofibroblasts, smooth muscle cells, pericytes, endothelium and inflammatory cells. α-smooth muscle actin (α-SMA)...
Heinz Läubli,Lubor Borsig
Heinz Läubli
Lung metastasis remains the major cause of cancer related mortality in patients with breast, gastrointestinal, sarcoma, melanoma and kidney cancer. Here we characterize the expression of selectins during metastatic lung colonization and ana...
Mesenchymal Stem Cells Overexpressing IFN-β Inhibit Breast Cancer Growth and Metastases through Stat3 Signaling in a Syngeneic Tumor Model [0.03%]
骨髓间充质干细胞过表达IFN-β通过STAT3信号抑制乳腺癌的生长和转移：同基因肿瘤模型研究
Xiaoyang Ling,Frank Marini,Marina Konopleva et al.
Xiaoyang Ling et al.
We previously demonstrated that mesenchymal stem/stromal cells (MSC) are recruited to tumors and that IFN-β produced by MSC inhibited tumor growth in xenograft models. Because of a deficient immune system, murine xenograft models cannot fu...
VE-cadherin Regulates Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Sensitivity to Apoptosis [0.03%]
血管性血细胞黏附分子调节费城染色体阳性急性淋巴细胞白血病的凋亡敏感性
Heather O&#x;Leary,Stephen M Akers,Debra Piktel et al.
Heather O&#x;Leary et al.
The mechanisms by which the bone marrow microenvironment regulates tumor cell survival are diverse. This study describes the novel observation that in addition to Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL) cel...
Chemokines and Cancer Progression: A Qualitative Review on the Role of Stromal Cell-derived Factor 1-alpha and CXCR4 in Endometrial Cancer [0.03%]
趋化因子与子宫内膜癌进展：基质细胞来源因子1-α和CXCR4的作用机制综述
Ashley S Felix,Robert Edwards,Robert Bowser et al.
Ashley S Felix et al.
The goal of this paper was to examine the literature related to stromal cell-derived factor 1-alpha (SDF-1alpha) and its receptor CXCR4 in endometrial cancer, as expression of these biomarkers has been implicated in an aggressive phenotype ...
T cells and stromal fibroblasts in human tumor microenvironments represent potential therapeutic targets [0.03%]
肿瘤微环境中的T细胞和基质成纤维细胞代表潜在的治疗靶点
Jennifer L Barnas,Michelle R Simpson-Abelson,Sandra J Yokota et al.
Jennifer L Barnas et al.
The immune system of cancer patients recognizes tumor-associated antigens expressed on solid tumors and these antigens are able to induce tumor-specific humoral and cellular immune responses. Diverse immunotherapeutic strategies have been u...
The hemopoietic stem cell niche versus the microenvironment of the multiple myeloma-tumor initiating cell [0.03%]
造血干细胞生态位与多发性骨髓瘤肿瘤始动细胞的微环境
Dov Zipori
Dov Zipori
Multiple myeloma cells are reminiscent of hemopoietic stem cells in their strict dependence upon the bone marrow microenvironment. However, from all other points of view, multiple myeloma cells differ markedly from stem cells. The cells pos...
The NF-κB/AKT-dependent Induction of Wnt Signaling in Colon Cancer Cells by Macrophages and IL-1β [0.03%]
巨噬细胞和IL-1β通过NF-κB/AKT诱导结肠癌细胞中Wnt信号通路的活化作用
Pawan Kaler,Bramara N Godasi,Leonard Augenlicht et al.
Pawan Kaler et al.
Progression of colon cancer from microadenoma to macroscopic tumors is coupled to augmentation of canonical Wnt signaling. We recently reported that tumor associated macrophages, through interleukin 1β (IL-1β) dependent phosphorylation of...