Microdialysis combined with proteomics for protein identification in breast tumor microenvironment in vivo [0.03%]
体内乳腺肿瘤微环境的微观透析与蛋白质组学结合鉴定蛋白成分
Baogang J Xu,Wenwei Yan,Bojana Jovanovic et al.
Baogang J Xu et al.
Tumor microenvironment constitutes a reservoir for proteins released from tumor cells and the host, which can contribute significantly to tumor growth and invasion. This study aims to apply a method of combining in vivo microdialysis and pr...
Kinetics of host cell recruitment during dissemination of diffuse malignant peritoneal mesothelioma [0.03%]
弥漫性恶性腹膜间皮瘤播散过程中宿主细胞募集的动态过程研究
Nathan R Miselis,Bonnie W Lau,Zhijin Wu et al.
Nathan R Miselis et al.
Diffuse malignant mesothelioma is an aggressive tumor which displays a median survival of 11.2 months and a 5-year survival of less than 5% emphasizing the need for more effective treatments. This study uses an orthotopic model of malignant...
Expression Pattern of the Pro-apoptotic Gene PAR-4 During the Morphogenesis of MCF-10A Human Mammary Epithelial Cells [0.03%]
PAR-4促凋亡基因在MCF-10A人乳腺上皮细胞形态发发生过程中表达模式的研究
Simone A de Bessa Garcia,Michelly C Pereira,Maria A Nagai
Simone A de Bessa Garcia
The histological organization of the mammary gland involves a spatial interaction of epithelial and myoepithelial cells with the specialized basement membrane (BM), composed of extra-cellular matrix (ECM) proteins, which is disrupted during...
Expression of Human MDGA1 Increases Cell Motility and Cell-Cell Adhesion and Reduces Adhesion to Extracellular Matrix Proteins in MDCK Cells [0.03%]
人MDGA1的表达增加细胞运动性和细胞间粘附并减少与细胞外基质蛋白的粘附（在MDCK细胞中）
Antonio Díaz-López,Pilar Iniesta,Alberto Morán et al.
Antonio Díaz-López et al.
Characterization of the novel human protein MDGA1 (MAM Domain containing Glycosylphosphatidylinositol Anchor-1) has been reported in our laboratory in the past few years. hMDGA1 is a glycoprotein containing 955 aminoacids (137 kDa) attached...
The Involvement of RCAS1 in Creating a Suppressive Tumor Microenvironment in Patients with Salivary Gland Adenocarcinoma [0.03%]
RCAS1在腺癌患者颌下腺肿瘤微环境构建中的作用研究
Magdalena Dutsch-Wicherek,Agata Lazar,Romana Tomaszewska
Magdalena Dutsch-Wicherek
The tumor microenvironment is the tissue that determines the growth and progression of the tumor as well as its ability to initiate metastases. The aim of the present study has been to evaluate the role of RCAS1 in creating the suppressive ...
Myeloid cells in cancer progression: unique subtypes and their roles in tumor growth, vascularity, and host immune suppression [0.03%]
髓细胞在癌症进展中的作用：独特的亚型及其在肿瘤生长、血管生成和宿主免疫抑制中的角色
Pampee P Young,Shidrokh Ardestani,Bin Li
Pampee P Young
Leukocytic infiltrates, particularly myeloid cells, can stimulate an anti-tumor immune response, but more often they stimulate tumor development, including promoting invasion, tumor growth, angiogenesis, and metastasis. Distinct myeloid phe...
Daniel L Worthley,Andrew S Giraud,Timothy C Wang
Daniel L Worthley
The extracellular components of the cancer microenvironment play a critical role in tumor initiation, progression and invasion. In this review we examine the normal formation and function of the basement membrane and extracellular matrix. W...
A digest on the role of the tumor microenvironment in gastrointestinal cancers [0.03%]
胃肠癌症中肿瘤微环境作用的综述
Martin Augsten,Christina Hägglöf,Cristina Peña et al.
Martin Augsten et al.
Experimental studies and analyses of clinical material have convincingly demonstrated that tumor formation and progression occurs through a concerted action of malignant cells and the surrounding microenvironment of the tumor stroma. The tu...
Vijay G Peddareddigari,Dingzhi Wang,Raymond N Dubois
Vijay G Peddareddigari
Colorectal cancer is the second leading cause of cancer-related mortality in the United States. Therapeutic developments in the past decade have extended life expectancy in patients with metastatic disease. However, metastatic colorectal ca...
Xiao-Feng Le,Omar Merchant,Robert C Bast et al.
Xiao-Feng Le et al.
Cancer metastasis results from a multi-step cascading process that includes: 1) vascularization of the primary tumor; 2) detachment and invasion of cancer cells; 3) intravasation into lymphatic and blood vessels; 4) survival and arrest in t...