Israel Vlodavsky,Phillip Beckhove,Immanuel Lerner et al.
Israel Vlodavsky et al.
Heparan sulfate proteoglycans (HSPGs) are primary components at the interface between virtually every eukaryotic cell and its extracellular matrix. HSPGs not only provide a storage depot for heparin-binding molecules in the cell microenviro...
Roles of bone marrow cells in skeletal metastases: no longer bystanders [0.03%]
骨髓细胞在骨骼转移中的作用：不再仅仅是旁观者
Serk In Park,Fabiana N Soki,Laurie K McCauley
Serk In Park
Bone serves one of the most congenial metastatic microenvironments for multiple types of solid tumors, but its role in this process remains under-explored. Among many cell populations constituting the bone and bone marrow microenvironment, ...
Transforming Growth Factor-β1 (TGF-β1) Driven Epithelial to Mesenchymal Transition (EMT) is Accentuated by Tumour Necrosis Factor α (TNFα) via Crosstalk Between the SMAD and NF-κB Pathways [0.03%]
转化生长因子-β1（TGF-β1）介导的上皮间质转化（epithelial to mesenchymal transition，EMT）通过SMAD和NF-κB通路相互作用加剧肿瘤坏死因子α（TNFα）的影响
Lee A Borthwick,Aaron Gardner,Anthony De Soyza et al.
Lee A Borthwick et al.
Epithelial to mesenchymal transition (EMT) is a process by which an epithelial cell alters its phenotype to that of a mesenchymal cell and plays a critical role in embryonic development, tumour invasion and metastasis and tissue fibrosis. T...
Scott A Guelcher,Julie A Sterling
Scott A Guelcher
Certain tumors, such as breast, frequently metastasize to bone where they can induce bone destruction. Currently, it is well-accepted that the tumor cells are influenced by other cells and growth factors present in the bone microenvironment...
Jeroen T Buijs,Keith R Stayrook,Theresa A Guise
Jeroen T Buijs
Breast cancer is the most prevalent cancer among females worldwide. It has long been known that cancers preferentially metastasize to particular organs, and bone metastases occur in ∼70% of patients with advanced breast cancer. Breast canc...
Regulation of Epithelial-Mesenchymal Transition by Transmission of Mechanical Stress through Epithelial Tissues [0.03%]
上皮组织通过机械应力传递调节上皮-间充质转化现象
Nikolce Gjorevski,Eline Boghaert,Celeste M Nelson
Nikolce Gjorevski
Epithelial-mesenchymal transition (EMT) is a phenotypic shift wherein epithelial cells lose or loosen attachments to their neighbors and assume a mesenchymal-like morphology. EMT drives a variety of developmental processes, but may also be ...
Nicola Giuliani,Paola Storti,Marina Bolzoni et al.
Nicola Giuliani et al.
The bone marrow microenvironment in multiple myeloma is characterized by an increased microvessel density. The production of pro-angiogenic molecules is increased and the production of angiogenic inhibitors is suppressed, leading to an "ang...
Nicole Beauchemin
Nicole Beauchemin
Colorectal cancer cells establish a crosstalk with the tumor microenvironment, such that implantation and development of the tumor is generally favoured. CRC progression depends on mutations in the tumor's oncogenic pathways as well as meta...
Joseph L Sottnik,Jian Zhang,Jill A Macoska et al.
Joseph L Sottnik et al.
The tumor microenvironment (TME) is a very complex niche that consists of multiple cell types, supportive matrix and soluble factors. Cells in the TME consist of both host cells that are present at tumor site at the onset of tumor growth an...
Recent advances in colorectal cancer research: the microenvironment impact [0.03%]
近年结直肠癌研究进展：微环境的影响
Anne-Laure Pin,François Houle,Jacques Huot
Anne-Laure Pin