MicroRNA Dysregulation in Colon Cancer Microenvironment Interactions: The Importance of Small Things in Metastases [0.03%]
结肠癌微环境互作中的microRNA失调：小分子在转移中的重要性
Sabina Pucci,Paola Mazzarelli
Sabina Pucci
The influence of the microenvironment through the various steps of cancer progression is signed by different cytokines and growth factors, that could directly affect cell proliferation and survival, either in cancer and stromal cells. In co...
Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer [0.03%]
肿瘤相关巨噬细胞(TAM)与结直肠癌炎症的关系研究进展
Marco Erreni,Alberto Mantovani,Paola Allavena
Marco Erreni
Experimental and epidemiological studies indicate a strong link between chronic inflammation and tumor progression. Human colorectal cancer (CRC), a major cause of cancer-related death in Western countries, represents a paradigm for this li...
Denis Gingras,Richard Béliveau
Denis Gingras
Several studies indicate that Western dietary and lifestyle factors are responsible for the high incidence of colorectal cancer in industrialized countries. Diets rich in red and processed meat, refined starches, sugar, and saturated and tr...
Johannes Rolin,Azzam A Maghazachi
Johannes Rolin
The effects of lysophospholipids (LPLs) on cancer microenvironment is a vast and growing field. These lipids are secreted physiologically by various cell types. They play highly important roles in the development, activation and regulation ...
Partial mesenchymal to epithelial reverting transition in breast and prostate cancer metastases [0.03%]
乳腺癌和前列腺癌转移灶中的部分间叶细胞向上皮细胞的逆转分化现象
Yvonne Chao,Qian Wu,Marie Acquafondata et al.
Yvonne Chao et al.
Epithelial to mesenchymal transition (EMT) is an oft-studied mechanism for the initiation of metastasis. We have recently shown that once cancer cells disseminate to a secondary organ, a mesenchymal to epithelial reverting transition (MErT)...
Adipocytes Promote B16BL6 Melanoma Cell Invasion and the Epithelial-to-Mesenchymal Transition [0.03%]
脂肪细胞促进B16BL6黑色素瘤细胞侵袭和上皮间质转化
Kyoko Kushiro,Randy A Chu,Akanksha Verma et al.
Kyoko Kushiro et al.
Metastatic melanoma is one of the most deadly and evasive types of cancer. On average, cancer patients with metastatic melanoma survive only 6-9 months after diagnosis. Epidemiological and animal studies suggest that obesity increases the m...
The liver prometastatic reaction of cancer patients: implications for microenvironment-dependent colon cancer gene regulation [0.03%]
肝转移反应与结肠直肠癌基因调控的关系
Fernando Vidal-Vanaclocha
Fernando Vidal-Vanaclocha
Colon cancer frequently metastasizes to the liver but the genetic and phenotypic properties of specific cancer cells able to implant and grow in this organ have not yet been established. The contribution of the patient's genetic, physiologi...
Kimberly Noonan,Ivan Borrello
Kimberly Noonan
The bone marrow (BM) is the site of disease in myeloma and possesses unique immune characteristics involved in the pathobiology of the disease. Interactions of plasma cells with stromal cells, osteoclasts, osteoblasts, myeloid and lymphoid ...
Ping Wu,Gareth J Morgan
Ping Wu
Myeloma bone disease (BD) not only impairs quality of life, but is also associated with impaired survival. Studies of the biology underlying BD support the notion that the increased osteoclastogenesis and suppressed osteoblastogenesis, is b...
Anjali Mishra,Yusuke Shiozawa,Kenneth J Pienta et al.
Anjali Mishra et al.
A variety of tumor cells preferentially home to the bone. The homing of cancer cells to the bone represents a multi-step process that involves malignant progression of the tumor, invasion of the tumor through the extracellular matrix and th...