Demelza J Ireland,Haydn T Kissick,Manfred W Beilharz
Demelza J Ireland
Malignant mesothelioma (MM) appears to be responsive to immunotherapy. The lack of complete tumour cure as a result of many immunotherapies tested to date suggests that the immune response to MM is complex and multi-parametric. Regulatory T...
The Tumor-Promoting Flow of Cells Into, Within and Out of the Tumor Site: Regulation by the Inflammatory Axis of TNFα and Chemokines [0.03%]
肿瘤促进的细胞流入、在肿瘤内流动和流出肿瘤位点的情况：由TNFα和化学因子炎症轴调节
Adit Ben-Baruch
Adit Ben-Baruch
Tumors are dynamic organs, in which active processes of cell motility affect disease course by regulating the composition of cells at the tumor site. While sub-populations of tumor-promoting leukocytes are recruited inward and endothelial c...
Matrix metalloproteinases in cytotoxic lymphocytes impact on tumour infiltration and immunomodulation [0.03%]
细胞毒淋巴细胞中的基质金属蛋白酶影响肿瘤浸润和免疫调节
Karin Edsparr,Per H Basse,Ronald H Goldfarb et al.
Karin Edsparr et al.
To efficiently combat solid tumours, endogenously or adoptively transferred cytotoxic T cells and natural killer (NK) cells, need to leave the vasculature, traverse the interstitium and ultimately infiltrate the tumour mass. During this loc...
Sonia Vallet,Noopur Raje
Sonia Vallet
The majority of patients with multiple myeloma develop bone osteolytic lesions, which may lead to severe complications, including pain and fractures. The pathogenesis of bone disease depends on uncoupled bone remodeling, characterized by in...
Toward an integrative analysis of the tumor microenvironment in ovarian epithelial carcinoma [0.03%]
卵巢上皮癌肿瘤微环境的整合分析
Ryan N Serio
Ryan N Serio
Ovarian epithelial carcinomas are heterogeneous malignancies exhibiting great diversity in histological phenotypes as well as genetic and epigenetic aberrations. A general early event in tumorigenesis is regional dissemination into the peri...
Antonio Sica,Chiara Porta,Sara Morlacchi et al.
Antonio Sica et al.
The construction of an inflammatory microenvironment provides the fuel for cancer development and progression. Hence, solid tumors promote the expansion and the recruitment of leukocyte populations, among which tumor-associated myeloid cell...
The inflammatory tumor microenvironment, epithelial mesenchymal transition and lung carcinogenesis [0.03%]
炎症性肿瘤微环境、上皮间充质转化与肺癌发生
Eileen L Heinrich,Tonya C Walser,Kostyantyn Krysan et al.
Eileen L Heinrich et al.
The inflammatory tumor microenvironment (TME) has many roles in tumor progression and metastasis, including creation of a hypoxic environment, increased angiogenesis and invasion, changes in expression of microRNAs (miRNAs) and an increase ...
Noor A Lokman,Miranda P Ween,Martin K Oehler et al.
Noor A Lokman et al.
Annexin A2 is a calcium-dependent, phospholipid-binding protein found on various cell types. It is up-regulated in various tumor types and plays multiple roles in regulating cellular functions, including angiogenesis, proliferation, apoptos...
Nitric Oxide (NO) and Cyclooxygenase-2 (COX-2) Cross-Talk in Co-Cultures of Tumor Spheroids with Normal Cells [0.03%]
肿瘤球体与正常细胞共培养体系中一氧化氮(NO)和环氧合酶-2(COX-2)的相互作用
Roman Paduch,Martyna Kandefer-Szerszeń
Roman Paduch
Cyclooxygenases (COX), prostaglandin E(2) (PGE(2)) and nitric oxide (NO) are believed to be some of the most important factors related to colon cancer growth and metastasis. In this study, we aimed to investigate the associations between CO...