Jie Li,Lin Chen,Zhihai Qin
Jie Li
Tumors are highly complex tissues composed of neoplastic cells and different kinds of stromal cells. Tumor stromal cells, especially fibroblasts, play important roles during the multistep development of tumors. In this review, the two-faced...
Deciphering the Key Features of Malignant Tumor Microenvironment for Anti-cancer Therapy [0.03%]
揭秘恶性肿瘤微环境的特征以寻求抗肿瘤治疗方案
Bingxue Shang,Gaochuan Zhang,Yanyan Pan et al.
Bingxue Shang et al.
Tumor microenvironment (TME) is important in tumor development and may be a target for anti-cancer therapy. The genesis of TME is a dynamic process that is regulated by intrinsic and extrinsic factors and coordinated by multiple genes, cell...
Exosomes in Cancer Microenvironment and Beyond: have we Overlooked these Extracellular Messengers? [0.03%]
癌症微环境中的外泌体及其他方面：我们忽视了这些细胞间通讯介质吗？
Ruowen Ge,Evan Tan,Soheila Sharghi-Namini et al.
Ruowen Ge et al.
Cancer is a complex organ whose behavior is not only influenced by genetic and epigenetic changes in cancer cells but also by stromal cells, local extracellular matrix and specific tissue architecture. Intercellular communications within th...
Zhen-Yu Ding,Xue-Lin Zou,Yu-Quan Wei
Zhen-Yu Ding
The cancer microenvironment is constituted of non-transformed host stromal cells such as endothelial cells, fibroblasts, various immune cells, and a complex extra-cellular matrix secreted by both the normal and neoplastic cells embedded in ...
Role of bone marrow-derived cells in angiogenesis: focus on macrophages and pericytes [0.03%]
骨髓来源细胞在血管生成中的作用：聚焦于巨噬细胞和周细胞
Yanping Ding,Nan Song,Yongzhang Luo
Yanping Ding
Tumor growth relies on the formation of new blood vessels to receive an adequate supply of oxygen and nutrient. This process is facilitated by both the remodeling of the pre-existing vasculatures and the recruitment of the progenitor/stem c...
Qian Xiao,Gaoxiang Ge
Qian Xiao
Lysyl oxidase (LOX) family oxidases, LOX and LOXL1-4, oxidize lysine residues in collagens and elastin, resulting in the covalent crosslinking and stabilization of these extracellular matrix (ECM) structural components, thus provide collage...
Signification of Hypermethylated in Cancer 1 (HIC1) as Tumor Suppressor Gene in Tumor Progression [0.03%]
HIC1作为肿瘤抑制基因在肿瘤进展中的意义研究分析报告
Jianghua Zheng,Dan Xiong,Xueqing Sun et al.
Jianghua Zheng et al.
Hypermethylated in cancer 1(HIC1) was identified as a strong suppressor gene in chromosome region 17p13.3 telomeric to TP53. This gene encodes a transcriptional repressor and is ubiquitously expressed in normal tissues but downexpressed in ...
Role of integrins in regulating proteases to mediate extracellular matrix remodeling [0.03%]
整合素通过调控蛋白酶介导细胞外基质重塑的作用
Jiao Yue,Kun Zhang,Jianfeng Chen
Jiao Yue
The extracellular matrix (ECM) is an extracellular scaffold composed of complex mixtures of proteins that plays a pivotal role in tumor progression. ECM remodeling is crucial for tumor migration and invasion during the process of metastasis...
Contribution of Fibroblast and Mast Cell (Afferent) and Tumor (Efferent) IL-6 Effects within the Tumor Microenvironment [0.03%]
肿瘤微环境中成纤维细胞和肥大细胞（传入）及肿瘤（传出）中IL-6效应的贡献
Honor J Hugo,Stephanie Lebret,Eva Tomaskovic-Crook et al.
Honor J Hugo et al.
Hyperactive inflammatory responses following cancer initiation have led to cancer being described as a 'wound that never heals'. These inflammatory responses elicit signals via NFκB leading to IL-6 production, and IL-6 in turn has been sho...