Isolation, genomic characterization, and biofilm eradication activity of vB_PaP_DMTU_1, a novel lytic bacteriophage against Pseudomonas aeruginosa [0.03%]
铜绿假单胞菌新型裂解噬菌体 vB_PaP_DMTU_1 的分离、基因组表征及其抗生物被膜活性研究
Dhirangkana Bora,Ajit Kumar Singh,Anupam Nath Jha et al.
Dhirangkana Bora et al.
Biofilm-associated Pseudomonas aeruginosa (P. aeruginosa) infections pose significant therapeutic challenges owing to their intrinsic resistance to conventional antibiotics. With targeted bacterial lysis and biofilm degradation capabilities...
Gnotobiotic mouse models as tools for dissecting the role of the microbiota in allergy: contributions from the laboratory of gnotobiology in Nový Hrádek [0.03%]
无菌小鼠模型作为分析微生物群在过敏反应中作用的工具：捷克共和国诺维胡拉德克实验室的无菌动物研究贡献
I Schabussova,H Kozakova,A Inic-Kanada et al.
I Schabussova et al.
Gnotobiotic mouse models occupy a unique position in allergy research as the only systems that allow causal links between defined microbial inputs and specific immune outcomes. This review summarises the long-term contributions of the Labor...
EDTA enhances antimicrobial activity of PR-39 and Protegrin-1 antimicrobial peptides against carbapenem-resistant Pseudomonas aeruginosa in serum [0.03%]
乙二胺四乙酸增强肽类抗生素PR-39和Protegrin-1的抗菌活性以对抗碳青霉烯耐药的绿脓杆菌感染
Lukáš Vacek,Antonín Pavelka,Břetislav Lipový et al.
Lukáš Vacek et al.
Carbapenem-resistant Pseudomonas aeruginosa represents a frequent and clinically challenging pathogen responsible for both acute and chronic infections. Antimicrobial peptides are emerging as a promising class of novel therapeutic agents du...
Interplay between enterotoxigenicity, antimicrobial resistance, and persistence mechanisms in Staphylococcus spp. across different origins [0.03%]
葡萄球菌属中产生肠毒素、耐药性和持久性机制的互作关系分析——不同来源间的比较研究
Júlia Koreneková,Petra Olejníková,Monika Hrušková et al.
Júlia Koreneková et al.
Staphylococcus spp. represent a persistent concern in food-related environments due to the interplay between virulence traits, antimicrobial resistance, and persistence mechanisms. This study comparatively characterized antimicrobial resist...
Centenary of Jaroslav Šterzl : This article celebrates the fact that the fields of immunology in the East and West are now on par, which is largely thanks to the genius and perseverance of Jaroslav Šterzl [0.03%]
Jaroslav Šterzl百年纪念：东西方免疫学领域如今已齐头并进，这在很大程度上归功于Jaroslav Šterzl的天才和毅力。
Ivan Lefkovits
Ivan Lefkovits
Gut microbiota and cancer immunotherapy: from dysbiosis to personalized immune checkpoint blockade optimization [0.03%]
肠道菌群和癌症免疫治疗：从菌群失调到个性化免疫检查点阻断优化
Fatima Akram,Salika Zainab,Ifrah Shabbir et al.
Fatima Akram et al.
Cancer has become one of the most prominent causes of death worldwide due to its increasing mortality rate. Immune checkpoint blockade therapy is an effective regimen for tumor control. Still, it faces challenges, including primary resistan...
Heterologous expression of wild-type and Lys99Ala mutant L-asparaginase from Lachancea thermotolerans in Pichia pastoris: culture optimization and laboratory-scale bioreactor production [0.03%]
热耐酒酵母野生型和Lys99Ala突变型L-天冬酰胺酶在毕赤酵母中的异源表达：培养优化及实验室规模生物反应器生产
Buse Çaloğlu Susamaz,Katja Koschorreck,Vlada B Urlacher et al.
Buse Çaloğlu Susamaz et al.
L-Asparaginase (L-ASNase) is an enzyme of significant therapeutic value within the pharmaceutical industry, primarily due to its clinical efficacy in treating acute lymphoblastic leukemia (ALL). Despite its benefits, the clinical applicatio...
Modulating effects of Lactobacillus acidophilus LA15 on immune response and gut microbiota in cyclophosphamide-induced immunosuppressed mice [0.03%]
鼠李糖乳杆菌LA15调节免疫抑制小鼠的免疫反应和肠道菌群的作用机制研究
Zhixian Chen,Qian Cheng,Xiaoli Zhang et al.
Zhixian Chen et al.
The gut microbiota plays a fundamental role in modulating host immune homeostasis. Lactobacillus (L.) acidophilus, as a predominant probiotic, has garnered significant research interest for its potential immunoregulatory capabilities. In th...
ESBL and carbapenemase-producing enteric pathogens in animal-origin foods: a one health perspective [0.03%]
动物源食品中产生ESBL和碳青霉烯酶的肠杆菌科病原菌：“同一健康”视角
Sarah Ahmad Khan,Shirjeel Ahmad Siddiqui,Samreen et al.
Sarah Ahmad Khan et al.
The frequent detection of extended-spectrum β-lactamase (ESBL-E) and carbapenemase-producing Enterobacteriaceae (CPE) in foods of animal origin raises concerns regarding the dissemination of antimicrobial resistance (AMR). Dairy products, ...
Gut microbiome-mediated bioactive ingredients and health benefits of medicinal and edible fermented products: A comprehensive review [0.03%]
肠道微生物介导的药用和可食用发酵产品的活性成分及其健康效益：综述
Chuntian Liu,Song Zhang,Qiulin Yue et al.
Chuntian Liu et al.
Fermented foods and beverages represent dynamic biological ecosystems that integrate microbial communities, bioactive metabolites, and host interactions to promote health across nutritional, functional, and therapeutic domains. This compreh...