Virtual screening and molecular dynamics analysis of Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitors targeting pyrimidine biosynthesis pathway
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Malaria caused by Plasmodium falciparum remains a major global health challenge, exacerbated by the emergence of resistance to artemisinin-based combination therapies. Dihydroorotate dehydrogenase (PfDHODH), an essential enzyme in parasite pyrimidine biosynthe... ...
