In the Huh7 Hepatoma Cells Diclofenac and Indomethacin Activate Differently the Unfolded Protein Response and Induce ER Stress Apoptosis [0.03%]
在Huh7肝癌细胞中，Diclofenac和Indomethacin以不同的方式激活未折叠蛋白反应并诱导内质网应激凋亡
Silvia Franceschelli,Ornella Moltedo,Giuseppina Amodio et al.
Silvia Franceschelli et al.
Non-steroidal anti-inflammatory drugs (NSAIDs) are cyclooxygenases (COXs) inhibitors frequently used in the treatment of acute and chronic inflammation. Side effects of NSAIDs are often due to their ability to induce apoptosis. Located at t...
Thalidomide Analogues Suppress Lipopolysaccharide-Induced Synthesis of TNF-α and Nitrite, an Intermediate of Nitric Oxide, in a Cellular Model of Inflammation [0.03%]
塞来昔布抑制LPS刺激的巨噬细胞中TNF-α和一氧化氮生成
David Tweedie,Kathryn A Frankola,Weiming Luo et al.
David Tweedie et al.
An unregulated neuroinflammation accompanies numerous chronic and acute neurodegenerative disorders and it is postulated that such a neuroinflammatory component likely exacerbates disease progression. A key player in brain inflammation is t...
Regions which are Responsible for Swapping are also Responsible for Folding and Misfolding [0.03%]
参与交换的区域也负责折叠和错误折叠
Oxana V Galzitskaya
Oxana V Galzitskaya
Domain swapping is a term used to describe a process when two or more protein chains exchange identical structural elements. Some cases of amyloid formation can be explained through a domain swapping mechanism therefore this deserves theore...
Effects of red grape juice consumption on high density lipoprotein-cholesterol, apolipoprotein AI, apolipoprotein B and homocysteine in healthy human volunteers [0.03%]
红葡萄汁摄取对健康人体内高密度脂蛋白胆固醉、载脂蛋白AI、载脂蛋白B和同型半胱氨 酸的影响
Mohammad H Khadem-Ansari,Yousef Rasmi,Fatemeh Ramezani
Mohammad H Khadem-Ansari
It has suggested that grape juice consumption has lipid- lowering effect and it is associated with a decreased risk of heart disease. We aimed to evaluate the effects of red grape juice (RGj) consumption on high density lipoprotein-choleste...
Coordination between nitric oxide and superoxide anion radical during progressive exercise in elite soccer players [0.03%]
优秀足球运动员在渐进性运动过程中一氧化氮和超氧阴离子自由基的相互作用
Dusica Djordjevic,Vladimir Jakovljevic,Dejan Cubrilo et al.
Dusica Djordjevic et al.
Background: Exercise increases production of reactive oxygen and nitrogen species (RONS) via several mechanisms. Inter alia, increased blood flow during exercise exposes endothelial cells to shear stress, resulting in inc...
Carolyn A Rankin,Ambrish Roy,Yang Zhang et al.
Carolyn A Rankin et al.
Parkin belongs to a class of multiple RING domain proteins designated as RBR (RING, in between RING, RING) proteins. In this review we examine what is known regarding the structure/function relationship of the Parkin protein. Parkin contain...
The Oxidative State of LDL is the Major Determinant of Anti/Prooxidant Effect of Coffee on Cu Catalysed Peroxidation [0.03%]
LDL氧化状态是咖啡对铜催化氧化的抗/促氧化效应的主要决定因素
Ciriaco Carru,Valeria Pasciu,Salvatore Sotgia et al.
Ciriaco Carru et al.
Antioxidants exert contrasting effect on low density lipoprotein (LDL) oxidation catalysed by metals, acting as pro-oxidants under select in vitro conditions. Through our study on the effect of coffee on LDL oxidation, we identified the par...
Systematic comparison of crystal and NMR protein structures deposited in the protein data bank [0.03%]
对蛋白质数据表中的晶体和核磁蛋白结构的系统比较研究
Kresimir Sikic,Sanja Tomic,Oliviero Carugo
Kresimir Sikic
Nearly all the macromolecular three-dimensional structures deposited in Protein Data Bank were determined by either crystallographic (X-ray) or Nuclear Magnetic Resonance (NMR) spectroscopic methods. This paper reports a systematic comparis...
Potential therapeutic effects of vitamin e and C on placental oxidative stress induced by nicotine: an in vitro evidence [0.03%]
维生素E和C对尼古丁诱导的胎盘氧化应激的潜在治疗作用：体外证据
Chiara Gallo,Paolo Renzi,Stefano Loizzo et al.
Chiara Gallo et al.
There have been a few studies that examined the oxidative stress effects of nicotine during pregnancy and lactation. The adverse effect of prenatal smoking exposure on human fetal development and growth has been a major public health issue....
Leukocyte Count versus C-Reactive Protein Levels in Obese Portuguese Patients Aged 6-12 Years Old [0.03%]
肥胖对葡萄牙6至12岁儿童白细胞计数与C反应蛋白水平的影响
Henrique Nascimento,Susana Rocha,Carla Rego et al.
Henrique Nascimento et al.
Objectives: to evaluate whether total and differential WBC counts are altered in young obese patients (aged 6-12 years) and if a relationship exists between WBC counts and the severity of obesity as well as with CRP level...