Secretion of Legumain Increases in Conditioned Medium from DJ-1-Knockout Cells and in Serum from DJ-1-Knockout Mice [0.03%]
缺乏DJ-1细胞培养上清中豆目蛋白酶的分泌增多及缺乏DJ-1小鼠血清中豆目蛋白酶水平升高
Takuya Yamane,Izumi Kato-Ose,Tatsuji Sakamoto et al.
Takuya Yamane et al.
Background: Asparaginyl endopeptidase, also known as legumain (EC 3.4.22.34) shows strong activity in the mouse kidney. Legumain is also highly expressed in tumors. DJ-1/PARK7 is a Parkinson's disease- and cancer-associat...
Biochemical Characterization of Two Clinically-Relevant Human Fumarase Variants Defective for Oligomerization [0.03%]
两种临床相关的人体富马酸盐变异酶的生化表征：无法进行寡聚体化缺陷型
Artemisa Bulku,Todd M Weaver,Melanie B Berkmen
Artemisa Bulku
Background: Fumarase, a significant enzyme of energy metabolism, catalyzes the reversible hydration of fumarate to L-malate. Mutations in the FH gene, encoding human fumarase, are associated with fumarate hydratase defici...
Plasma L-Carnitine and L-Lysine Concentrations in HIV-Infected Patients [0.03%]
人类免疫缺陷病毒感染者的血浆L-左旋肉碱和L-赖氨酸浓度
Evgeny V Butorov
Evgeny V Butorov
Background: Virus infections are associated with significant alterations in host cells amino acids profiles that support biosynthetic demands necessary for production of viral progeny. Amino acids play an important role i...
Inflammatory Markers and Plasma Lipids in HIV Patients: A Correlation Analysis Study [0.03%]
HIV患者炎症标志物与血浆血脂的相关分析研究
Rudo Muswe,Olav Oktedalen,Danai T Zhou et al.
Rudo Muswe et al.
Background: Recent evidence suggests that HIV infection, even with treatment, increases the risk of coronary heart disease (CHD) and that both chronic inflammation and traditional risk factors play key roles in HIV-associ...
Comparative Studies on the Lipid Composition of Blood Plum (Haematostaphis Barteri) Pulp and Seed Oils [0.03%]
血 plum（Haematostaphis Barteri）果肉和种子油的脂质组成比较研究
Matthew Olaleke Aremu,Hashim Ibrahim,Chrysantus Andrew
Matthew Olaleke Aremu
Background: Exploring under-utilized plant fruits could be of high significance for food security and nutritional requirements, therefore, it can effectively add to the overall improvement of a nation's economy. Blood plu...
Effects of Triton X-100 and PEG on the Catalytic Properties and Thermal Stability of Lipase from Candida Rugosa Free and Immobilized on Glyoxyl-Agarose [0.03%]
Triton X-100 和 PEG 对甘露醇诱导的地衣芽孢杆菌脂酶性质的影响
Rafael F Perna,Poliana C Tiosso,Letícia M Sgobi et al.
Rafael F Perna et al.
Background: Candida rugosa Lipase (CRL) shows a very low alkaline stability that comprises its immobilization on glyoxyl-agarose, which requires pH above 10. In this way, an adaptation from the original method was used; a...
Hepatic and Aortic Arch Expression and Serum Levels of Syndecan-1 in ApoE-/- Mice [0.03%]
ApoE-/-小鼠肝脏和主动脉弓硫酸肝素蛋白多糖Syndecan-1的表达及血清水平分布特点
Elena I Leonova,Elena S Sadovnikova,Elvira R Shaykhutdinova et al.
Elena I Leonova et al.
Background: Heparan sulfate proteoglycan (HSPG) syndecan-1 (Sdc1) acts as a receptor for triglyceride-rich lipoproteins (TRLs), growth factors, chemokines and enzymes. Due to the disordered structure, its function is as d...
Docosahexaenoic Acid Inhibits Vascular Smooth Muscle Cell Proliferation Induced by Glucose Variability [0.03%]
docosahexaenoic酸抑制血糖波动诱导的血管平滑肌细胞增殖
Kaliyaperumal Rani,Nway Y Aung
Kaliyaperumal Rani
Background: Vascular Smooth Muscle cells (VSMC) enact crucial roles in early vasculogenesis and sustenance of vascular integrity. However, aberrant proliferation of VSMC followed by migration into the blood vessel wall le...
Alzheimer's Disease and Paraoxonase 1 (PON1) Gene Polymorphisms [0.03%]
载脂蛋白paraoxonase 1(PON1)基因多态性与阿尔茨海默病的关系研究进展
Mohsen Saeidi,Raheleh Shakeri,Abdoljalal Marjani et al.
Mohsen Saeidi et al.
Background: Some studies have indicated that human paraoxonase 1 (PON1) activity shows a polymorphic distribution. The aim of this study was to determine the distribution of PON1 polymorphism in patients with Alzheimer's ...
Hiroyuki Yamamoto,Syota Saito,Yoshikazu Sawaguchi et al.
Hiroyuki Yamamoto et al.
Background: Proteolysis constitutes a major post-translational modification. For example, proteases regulate the activation or inactivation of various proteins, such as enzymes, growth factors, and peptide hormones. Prote...