The Hepatitis C Virus NS5A Stimulates NS5B During In Vitro RNA Synthesis in a Template Specific Manner [0.03%]
丙型肝炎病毒NS5A以模板依赖性方式刺激NS5B体内RNA合成
Elizabeth M Quezada,Caroline M Kane
Elizabeth M Quezada
The hepatitis C virus (HCV) NS5B protein contains the RNA dependent RNA polymerase (RdRp) activity that catalyzes the synthesis of the viral genome with other host and viral factors. NS5A is an HCV-encoded protein previously shown to locali...
E Ducros,S Mirshahi,C Bermot et al.
E Ducros et al.
Activated protein C (APC) is a major control system of blood coagulation. APC prevents coagulation pathway by degrading Va and VIIIa plasma's coagulation factors. Protein C activation requires its binding to specific endothelial cell recept...
Primary Structure Revision and Active Site Mapping of E. Coli Isoleucyl-tRNA Synthetase by Means of Maldi Mass Spectrometry [0.03%]
基质辅助激光解析飞行时间质谱法测定大肠杆菌的异亮氨酰-TRNA合成酶活性中心及一级结构修正
Soria Baouz,Jean-Marie Schmitter,Lila Chenoune et al.
Soria Baouz et al.
The correct amino acid sequence of E. coli isoleucyl-tRNA synthetase (IleRS) was established by means of peptide mapping by MALDI mass spectrometry, using a set of four endoproteases (trypsin, LysC, AspN and GluC). Thereafter, the active si...
Alberto Loizzo,Stefano Loizzo,Anna Capasso
Alberto Loizzo
The evaluation of pain in the newborn and the infant is difficult because pain is mainly a subjective phenomenon. Until a few years ago, several myths persisted. First, the myth that children, especially infants, do not feel pain the way ad...
High G+C Content of Herpes Simplex Virus DNA: Proposed Role in Protection Against Retrotransposon Insertion [0.03%]
单纯疱疹病毒DNA高G+C含量：保护免遭逆转座子插入的作用说
Jay C Brown
Jay C Brown
The herpes simplex virus dsDNA genome is distinguished by an unusually high G+C nucleotide content. HSV-1 and HSV-2, for instance, have GC contents of 68% and 70% respectively, while that of the host (human) genome is 41%. To determine how ...
Does phenoloxidase contributed to the resistance? Selection with butane-fipronil enhanced its activities from diamondback moths [0.03%]
酚氧化酶参与抗性吗？丁烯氟虫腈诱导的 cabbage looper酚氧化酶活力增强
Shouzhu Liu,Hongtao Niu,Ting Xiao et al.
Shouzhu Liu et al.
Using microtitration method, the relationship between Phenoloxidase activity and the resistance of the diamondback moth Plutella xylostella (Linnaeus) to the novel insecticide butane-fipronil was determined in vitro. After selection of the ...
Calcium-induced conformational transition of trout ependymins monitored by tryptophan fluorescence [0.03%]
钙诱导的彩虹 Trout 髓帆蛋白构象变化的色氨酸荧光监测
Bernhard Ganss,Werner Hoffmann
Bernhard Ganss
Ependymins are secretory, calcium-binding sialoproteins which are the predominant constituents of the cerebrospinal fluid of many teleost fish. A bound form of these regeneration-responsive glycoproteins is associated with collagen fibrils ...
Svetlana Kirillova,Suresh Kumar,Oliviero Carugo
Svetlana Kirillova
One of the important fields to apply computational tools for domain boundaries prediction is structural biology. They can be used to design protein constructs that must be expressed in a stable and functional form and must produce diffracti...
Characterization of the Cdc6 Homologues from the Euryarchaeon Thermoplasma acidophilum [0.03%]
热酸盐噬温菌株(Cdc6同源体的特征)
Gyri Teien Haugland,Marte Innselset,Dominique Madern et al.
Gyri Teien Haugland et al.
Archaeal cell division cycle protein 6 (Cdc6) homologues are thought to be involved in the initiation process of DNA replication. In the present study, a biochemical characterization of the two Cdc6 proteins from the archaeon Thermoplasma a...
Influence of aromatic and aliphatic moieties on thrombin inhibitors potency [0.03%]
芳香族和脂肪族基团对凝血酶抑制剂活性的影响
Alexey Poyarkov,Xavier Rocabayera,Svetlana Poyarkova et al.
Alexey Poyarkov et al.
Thrombin is a plasma serine protease that plays a key role in coagulation and hemostasis but also in thromboembolic diseases. Direct thrombin inhibitors could be beneficial for future anticoagulant therapy in the prophylaxis of venous and a...