ABCB1, SLCO1B1 and UGT1A1 gene polymorphisms are associated with toxicity in metastatic colorectal cancer patients treated with first-line irinotecan [0.03%]
ABCB1，SLCO1B1和UGT1A1基因多态性与一线使用伊立替康治疗的转移性结直肠癌患者的毒性相关
Katrin E Rhodes,Wu Zhang,Dongyun Yang et al.
Katrin E Rhodes et al.
We tested specific gene polymorphisms known to be involved in the irinotecan (CPT-11) metabolic pathway. The combination of at least one SLCO1B1 521 T allele, one ABCB1 1236 C allele and one UGT1A1*28 variant 7 repeat demonstrated a statist...
Clinical Trial
Drug metabolism letters. 2007 Jan;1(1):23-30. DOI:10.2174/187231207779814328 2007
Heather M Harville,Richard Voorman,Jeffery J Prusakiewicz
Heather M Harville
Parabens are widely used preservatives in topical products, and are estrogenic in numerous experimental models. The typical cutaneous metabolism model, rat skin, hydrolyzes parabens much faster than human skin. Chronic application and absor...
Comparative Study
Drug metabolism letters. 2007 Jan;1(1):17-21. DOI:10.2174/187231207779814300 2007
In vitro inhibition of rat CYP1A1 and CYP1A2 by piceatannol, a hydroxylated metabolite of trans-resveratrol [0.03%]
白藜芦醇的羟基代谢产物pisatinol对大鼠CYP1A1和CYP1A2的抑制作用研究
Thomas K H Chang,Jie Chen,Chia-Ting Yu
Thomas K H Chang
Piceatannol and its parent compound, trans-resveratrol, decreased the in vitro catalytic activity of rat CYP1A1 and CYP1A2 by mixed inhibition. trans-Resveratrol was not a mechanism-based inactivator of rat CYP1A in vitro and the administra...
Verapamil, but not probenecid, co-administration can convert desloratadine to a sedating antihistamine in mice [0.03%]
维拉帕米而非丙烯茋联合给药可将地氯利定转化为具有镇静作用的抗组胺药物：小鼠模型研究
Anand Katta,Mugunthu Dhananjeyan,Crystal Bykowski et al.
Anand Katta et al.
The possibility that non-sedating antihistamines could elicit sedation in mice due to drug-induced inhibition of brain PgP was evaluated by measuring the ability of desloratadine alone or in combination with verapamil to cause ataxia in mic...
Effect of common NAT2 variant alleles in the acetylation of the major clonazepam metabolite, 7-aminoclonazepam [0.03%]
常见NAT2变异等位基因对克仑唑酮主要代谢产物7-氨基克仑唑酮乙酰化的影响
M Olivera,C Martínez,G Gervasini et al.
M Olivera et al.
We investigated the role of NAT2 on clonazepam acetylation, using transiently expressed human NAT2 alleles. The NAT25*B and the NAT2*6A variant alleles cause a 20 and 22-fold reduction in the Vmax, respectively. We conclude that NAT2 is res...
Chandra Prakash
Chandra Prakash