Yin and Yang Part Deux: CCN5 inhibits the pro-fibrotic effects of CCN2 [0.03%]
阴阳II：CCN5抑制CCN2的促纤维化作用
Andrew Leask
Andrew Leask
There is no treatment for fibrotic disease is a significant cause of mortality. CCN2 Members of the CCN family of matricellular proteins have a characteristic four domain structure. CCN2 (connective tissue growth factor) is believed to play...
Zhiyong Lin,Viswanath Natesan,Hong Shi et al.
Zhiyong Lin et al.
The vascular endothelium plays a fundamental role in the health and disease of the cardiovascular system. The molecular mechanisms regulating endothelial homeostasis, however, remain incompletely understood. CCN3, a member of the CCN (Cyr61...
Bethanie Morrison,Mary Lou Cutler
Bethanie Morrison
The mammary gland undergoes hormonally controlled cycles of pubertal maturation, pregnancy, lactation, and involution, and these processes rely on complex signaling mechanisms, many of which are controlled by cell-cell and cell-matrix adhes...
Joshua W Russo,John J Castellot
Joshua W Russo
CCN5 is one of six proteins in the CCN family. This family of proteins has been shown to play important roles in many processes, including proliferation, migration, adhesion, extracellular matrix regulation, angiogenesis, tumorigenesis, fib...
Vincenza Rita Lo Vasco
Vincenza Rita Lo Vasco
For a complex organism, short range signalling is not sufficient to coordinate the behaviour of all cells composing itself. The response to stimuli is the reprogramming of cell activity (resulting in differentiation, proliferation, stand by...
Andrew Leask,Bernard Perbal
Andrew Leask
Andrew Leask
Andrew Leask
The role of CCN proteins in vivo is only just becoming understood. A prototypical member of the CCN family, CCN3 suppresses proliferation. In a study in press, Shimoyama and colleagues show that mice lacking CCN3 have a hyperproliferative r...
Spatiotemporal expression of periostin during skin development and incisional wound healing: lessons for human fibrotic scar formation [0.03%]
骨形态发生蛋白受体相互作用蛋白 périostin 在皮肤发育及创伤愈合过程中时空表达模式及其对人类肥厚性瘢痕形成的意义研究
Hong-Ming Zhou,Jian Wang,Christopher Elliott et al.
Hong-Ming Zhou et al.
Differentiation of fibroblasts to myofibroblasts and collagen fibrillogenesis are two processes essential for normal cutaneous development and repair, but their misregulation also underlies skin-associated fibrosis. Periostin is a matricell...
Kristina C Wiesman,Lan Wei,Cassandra Baughman et al.
Kristina C Wiesman et al.
CCN5, a member of the CCN family of growth factors, inhibits the proliferation and migration of smooth muscle cells in cell culture and animal models. Expressed in both embryonic and adult tissues, CCN5 exhibits a matricellular localization...
Prostaglandin E(2) is crucial in the response of podocytes to fluid flow shear stress [0.03%]
前列腺素E2在足细胞对流体切应力反应中的重要作用
Tarak Srivastava,Ellen T McCarthy,Ram Sharma et al.
Tarak Srivastava et al.
Podocytes play a key role in maintaining and modulating the filtration barrier of the glomerulus. Because of their location, podocytes are exposed to mechanical strain in the form of fluid flow shear stress (FFSS). Several human diseases ar...