B cell block: is rituximab a new possible treatment for systemic sclerosis? [0.03%]
B细胞耗竭：利妥昔单抗可成为系统性硬化症的新疗法吗？
Andrew Leask
Andrew Leask
There is no treatment for fibrotic diseases, including the autoimmune disease systemic sclerosis (sclerderma, SSc). Although broad spectrum immune suppressants have little to no effect on the fibrosis in SSc, agents targeting specific proin...
Andrew Leask
Andrew Leask
The CCN family of matricellular proteins are dysregulated in cancers, and may strategies targeting them may represent novel approaches to treating these diseases. A recent study from Huang and colleagues (Cancer Res. 70: 3340-50, 2010) sugg...
Andrew Leask
Andrew Leask
There is no treatment for fibrotic disease. TGFβ is known to promote fibrogenesis in vivo and in vitro, however, development of anti-fibrotic strategies targeting the TGFβ axis is problematic owing to the pleitropic nature of TGFβ action...
Mastering a mediator: blockade of CCN-2 shows early promise in human diabetic kidney disease [0.03%]
人糖尿病肾病中CCN-2的阻断展现初步疗效
Stephen M Twigg
Stephen M Twigg
In diabetes complications, CCN-2 (known originally as CTGF) has been implicated in diabetic nephropathy both as a marker and a mediator of disease. This commentary addresses CCN-2 in diabetic nephropathy, in the context of the recent public...
Commentary on a recent article-"A prostacyclin analogue, Iloprost, protects from bleomycin-induced fibrosis in mice" Zhu Y et al. Respir Res. 2010 Mar 20;11(1):34 [0.03%]
关于一篇近期论文的评论-“前列腺素I2类似物伊洛前列素对博来霉素致小鼠肺纤维化的保护作用”
Richard Stratton,Florence Newton
Richard Stratton
Data from our laboratory show that in vitro fibroblasts are exquisitely responsive to prostacyclin and the prostacyclin derivative Iloprost, which block their activation by TGFβ. A recent article by Zhu Y et al confirm these effects in viv...
TSP-1 in lung fibrosis [0.03%]
TSP-1在肺纤维化中的作用
Gianni M Di Guglielmo
Gianni M Di Guglielmo
Lung fibrosis is often treated with corticosteroids to reduce the inflammatory response, however, no effective treatment options exist for the underlying disease. An important player in the fibrotic cascade is the cytokine, transforming gro...
Selective regulation of nuclear orphan receptors 4A by adenosine receptor subtypes in human mast cells [0.03%]
人肥大细胞中腺苷受体亚型选择性调节孤儿核受体4A家族成员
Li Zhang,Catherine Paine,Ramiro Dip
Li Zhang
Nuclear orphan receptors 4A (NR4A) are early responsive genes that belong to the superfamily of hormone receptors and comprise NR4A1, NR4A2 and NR4A3. They have been associated to transcriptional activation of multiple genes involved in inf...
Steroid signaling activation and intracellular localization of sex steroid receptors [0.03%]
性类固醇激素信号激活及其受体的亚细胞定位分布
Tiziana Giraldi,Pia Giovannelli,Marzia Di Donato et al.
Tiziana Giraldi et al.
In addition to stimulating gene transcription, sex steroids trigger rapid, non-genomic responses in the extra-nuclear compartment of target cells. These events take place within seconds or minutes after hormone administration and do not req...
Decrypting the labyrinth of inflammatory cell signaling pathways: Editorial to the meeting "Inflammation 2010" [0.03%]
解读复杂的炎性细胞信号通路迷宫：“炎症2010”会议述评
Mareike Kelkel,Barbora Orlikova,Marc Diederich
Mareike Kelkel
Andrew Leask
Andrew Leask
Smoking causes oral fibrosis. In a recent report, Takeuchi and colleagues (J Dent Res 89:34-9, 2010) evaluate whether nicotine can directly elevate collagen production in gingival fibroblasts. They show that CCN2 (connective tissue growth f...