Autophagy and ATP-induced anti-apoptosis in antigen presenting cells (APC) follows the cytokine storm in patients after major trauma [0.03%]
重症创伤患者的细胞因子风暴后抗原呈递细胞（APC）的自噬和ATP诱导的抗凋亡作用
E Marion Schneider,Sarah Flacke,Fengguang Liu et al.
E Marion Schneider et al.
Severe trauma and the systemic inflammatory response syndrome (SIRS) occur as a result of a cytokine storm which is in part due to ATP released from damaged tissue. This pathology also leads to increased numbers of immature antigen presenti...
Breast cancer at bone metastatic sites: recent discoveries and treatment targets [0.03%]
骨转移性乳腺癌：近期发现和治疗目标
Osama Hussein,Svetlana V Komarova
Osama Hussein
Breast carcinoma is the most common cancer of women. Bones are often involved with breast carcinoma metastases with the resulting morbidity and reduced quality of life. Breast cancer cells arriving at bone tissues mount supportive microenvi...
Lisa J Crawford,Brian Walker,Alexandra E Irvine
Lisa J Crawford
The ubiquitin proteasome pathway plays a critical role in regulating many processes in the cell which are important for tumour cell growth and survival. Inhibition of proteasome function has emerged as a powerful strategy for anti-cancer th...
Andrew Leask
Andrew Leask
There are no approved drugs for treating the fibrosis in scleroderma (systemic sclerosis, SSc). Myfibroblasts within connective tissue express the highly contractile protein α-smooth muscle actin (α-SMA) and are responsible for the excess...
Satoshi Kubota,Masaharu Takigawa
Satoshi Kubota
CCN2, a classical member of the CCN family of matricellular proteins, is a key molecule that conducts cartilage development in a harmonized manner through novel molecular actions. During vertebrate development, all cartilage is primarily fo...
Lina Dagnino
Lina Dagnino
Integrin-linked kinase (ILK) is a scaffolding protein with central roles in tissue development and homeostasis. Much debate has focused on whether ILK is a bona fide or a pseudo- kinase. This aspect of ILK function has been complicated by t...
Andrew Leask
Andrew Leask
CCN2 (formerly known as connective tissue growth factor) was identified by several different laboratories approximately 20 years ago. Almost since its identification as a factor induced in normal fibroblasts by transforming growth factor β...
Purification and characterization of native human insulin-like growth factor binding protein-6 [0.03%]
人胰岛素样生长因子结合蛋白-6的纯化和特性分析
Andrea Taferner,Lucia Micutkova,Martin Hermann et al.
Andrea Taferner et al.
Insulin-like growth factor binding proteins (IGFBPs) are key regulators of insulin-like growth factor (IGF) mediated signal transduction and thereby can profoundly influence cellular phenotypes and cell fate. Whereas IGFBPs are extracellula...
Andrew Leask
Andrew Leask
Members of CCN family of matricellular proteins are being increasingly recognized by the translational research community as representing excellent targets for drug intervention. Although much effort has been expended in outlining the mecha...
Encapsulation of eukaryotic cells in alginate microparticles: cell signaling by TNF-alpha through capsular structure of cystic fibrosis cells [0.03%]
包封藻酸盐微粒中的真核细胞：通过囊性纤维化细胞的囊结构传递TNF-α信号
Stefania Mazzitelli,Monica Borgatti,Giulia Breveglieri et al.
Stefania Mazzitelli et al.
Entrapment of mammalian cells in natural or synthetic biomaterials represents an important tool for both basic and applied research in tissue engineering. For instance, the encapsulation procedures allow to physically isolate cells from the...