Spatial-temporal modulation of CCN proteins during wound healing in human skin in vivo [0.03%]
人皮肤伤口愈合过程中CCN蛋白的时空调节作用
Laure Rittié,Bernard Perbal,John J Castellot Jr et al.
Laure Rittié et al.
CCN proteins are important modulators of development and function of adult organs. In this study, we examined the localization and expression of the six CCN family members in normal adult human skin and during wound healing in vivo. Transcr...
When there's smoke there's…scleroderma: evidence that patients with scleroderma should stop smoking [0.03%]
有烟就有皮肤硬化病：患者应停止吸烟证据显示
Andrew Leask
Andrew Leask
There is no treatment for the autoimmune disease scleroderma (systemic sclerosis, SSc), a multisystem disorder characterized by vascular damage and fibrosis. In particular, SSc can severely affect the lung, resulting in pulmonary arterial h...
The gap junction as a "Biological Rosetta Stone": implications of evolution, stem cells to homeostatic regulation of health and disease in the Barker hypothesis [0.03%]
缝隙连接作为“生物罗塞塔石碑”：进化、干细胞对健康与疾病在巴克尔假设中的稳态调节的含义
James E Trosko
James E Trosko
The discovery of the gap junction structure, its functions and the family of the "connexin" genes, has been basically ignored by the major biological disciplines. These connexin genes code for proteins that organize to form membrane-associa...
Will o' the wisp: CCN4 as a novel molecular target in osteoarthritis [0.03%]
神秘而短寿的CCN4——骨关节炎潜在的新分子靶点
Andrew Leask
Andrew Leask
Osteoarthritis (OA), or degenerative arthritis, is characterized by mechanical stress-induced changes in cartilage and bone. OA is a leading cause of chronic disability in North America and Europe. A recent study written by Blom and colleag...
Further evidence for a role of endothelin-1 (ET-1) in critical limb ischaemia [0.03%]
血管紧张素生成酶抑制剂对下肢严重缺血的作用
Michael Richard Dashwood,Janice C S Tsui
Michael Richard Dashwood
Critical limb ischaemia (CLI), due to atherosclerotic arterial occlusion, affects over 20,000 people per year in the United Kingdom with many facing lower limb amputation and early death. A role for endothelin-1 (ET-1) in atherosclerosis is...
Exploiting notochord cells for stem cell-based regeneration of the intervertebral disc [0.03%]
利用脊索细胞进行基于干细胞的椎间盘再生治疗
Matthew R McCann,Corey A Bacher,Cheryle A Séguin
Matthew R McCann
The nucleus pulposus is an avascular and aneural tissue that has significant influence on the homeostasis and overall function of the intervertebral disc. The nucleus pulposus is comprised of a heterogeneous population of cells including la...
Hormesis provides a generalized quantitative estimate of biological plasticity [0.03%]
hormesis 提供了生物可塑性的量化估计通用方法
Edward J Calabrese,Mark P Mattson
Edward J Calabrese
Phenotypic plasticity represents an environmentally-based change in an organism's observable properties. Since biological plasticity is a fundamental adaptive feature, it has been extensively assessed with respect to its quantitative featur...
Stephen M Twigg,Sandra Irvine,Andrew Leask et al.
Stephen M Twigg et al.
Phagocytosis and digestion of pH-sensitive fluorescent dye (Eos-FP) transfected E. coli in whole blood assays from patients with severe sepsis and septic shock [0.03%]
人重度感染和脓毒性休克患者全血中内吞并消化pH敏感型荧光示踪菌（Eos-FP转基因大肠杆菌）的能力检测
Leonhard Schreiner,Markus Huber-Lang,Manfred E Weiss et al.
Leonhard Schreiner et al.
The function of phagocytic and antigen presenting cells is of crucial importance to sustain immune competence against infectious agents as well as malignancies. We here describe a reproducible procedure for the quantification of phagocytosi...