Andrew Leask
Andrew Leask
It is becoming increasingly apparent that many of the basic mechanisms underlying cancers also underlie fibrotic diseases. For example, the Sp1 family of transcription factors plays an essential role in controlling the gene expression of pr...
Tryptase activates isolated adult cardiac fibroblasts via protease activated receptor-2 (PAR-2) [0.03%]
阳离子蛋白酶胰舒降肽通过蛋白酶激活受体-2促进成人心脏成纤维细胞活化
David B Murray,Jennifer McLarty-Williams,Krishna T Nagalla et al.
David B Murray et al.
Protease activated receptor-2 (PAR-2) derived cycloxygenase-2 (COX-2) was recently implicated in a cardiac mast cell and fibroblast cross-talk signaling cascade mediating myocardial remodeling secondary to mechanical stress. We designed thi...
CCN3 suppresses mitogenic signalling and reinstates growth control mechanisms in Chronic Myeloid Leukaemia [0.03%]
CCN3抑制促有丝分裂信号并恢复慢性髓系白血病的生长调控机制
Lynn McCallum,Wanhua Lu,Susan Price et al.
Lynn McCallum et al.
CCN3, a tumour suppressor gene, is down-regulated as a result of BCR-ABL tyrosine kinase activity in Chronic Myeloid Leukaemia (CML). We have established a stable CCN3 expression model in the human K562 CML cell line and have further valida...
Elevated CCN2 expression in scleroderma: a putative role for the TGFβ accessory receptors TGFβRIII and endoglin [0.03%]
硬皮病中CCN2的表达上调：TGFβ辅助受体TGFβRIII和内皮素的潜在作用
Alan M Holmes,Markella Ponticos,Xu Shi-Wen et al.
Alan M Holmes et al.
The ability of TGFβ1 to act as a potent pro-fibrotic mediator is well established, potently inducing the expression of fibrogenic genes including type I collagen (COL1A2) and CCN2. Previously we have shown elevated expression of the TGFβ ...
CCN3/NOV small interfering RNA enhances fibrogenic gene expression in primary hepatic stellate cells and cirrhotic fat storing cell line CFSC [0.03%]
CCN3/NOV小干扰RNA增强初级肝星状细胞和肝硬化脂肪储存细胞系CFSC的促纤维基因表达
Erawan Borkham-Kamphorst,Claudia R van Roeyen,Eddy Van de Leur et al.
Erawan Borkham-Kamphorst et al.
Nephroblastoma overexpressed gene encodes a matricellular protein (CCN3/NOV) of the CCN family, comprising CCN1 (CYR61), CCN2 (CTGF), CCN4 (WISP-1), CCN5 (WISP-2), and CCN6 (WISP-3). CCN proteins are involved in the regulation of mitosis, a...
Andrew Leask
Andrew Leask
The oncogenic Ets family of transcription factors is now recognized to play a key role in fibroblasts as it controls the expression of a variety of pro-fibrotic genes, including the induction of CCN2 by transforming growth factor β. A rece...
Regulation of cytochrome P4501A by protein kinase C: the role of heat shock protein70 [0.03%]
蛋白质激酶C对细胞色素P4501A的调节作用及热休克蛋白70的作用
Manik C Ghosh,Arun K Ray
Manik C Ghosh
Carbofuran is a pesticide, which is used throughout the world as a nematicide and an acaricide. This pesticide integrates into living organisms through aquatic ecosystem. In earlier report, we had demonstrated that cytochrome P4501A was ind...
CCN1 contributes to skin connective tissue aging by inducing age-associated secretory phenotype in human skin dermal fibroblasts [0.03%]
CCN1通过诱导人皮肤成纤维细胞衰老相关分泌表型参与皮肤结缔组织衰老
Taihao Quan,Zhaoping Qin,Patrick Robichaud et al.
Taihao Quan et al.
Dermal connective tissue collagen is the major structural protein in skin. Fibroblasts within the dermis are largely responsible for collagen production and turnover. We have previously reported that dermal fibroblasts, in aged human skin i...
Pomegranate sensitizes Tamoxifen action in ER-α positive breast cancer cells [0.03%]
石榴敏感化雌激素受体-α阳性乳腺癌细胞的他莫昔芬作用
Shreya Banerjee,Suman Kambhampati,Inamul Haque et al.
Shreya Banerjee et al.
It is estimated that one in eight women will be affected with cancer during their lives, which means over 1 million women worldwide will be diagnosed with breast cancer in the year of 2011. Roughly, 70% of breast cancer will be estrogen rec...
Wei Sha,Andrew Leask
Wei Sha
The matricellular protein connective tissue growth factor (CTGF, CCN2) is overexpressed in several forms of cancer and may represent a novel target in anti-cancer therapy. However, whether CCN2 is expressed in melanoma cells is unknown. The...