The role of thrombospondins in wound healing, ischemia, and the foreign body reaction [0.03%]
血小板源性生长因子在伤口愈合、缺血及异物反应中的作用
Themis R Kyriakides,Susan Maclauchlan
Themis R Kyriakides
Thrombospondin (TSP) 1 and TSP2 have been implicated in the regulation of several processes during tissue repair. Due to their matricellular nature, these proteins are thought to modulate cell-matrix interactions through a variety of mechan...
Kim S Midwood,Gertraud Orend
Kim S Midwood
The extracellular matrix molecule tenascin-C is highly expressed during embryonic development, tissue repair and in pathological situations such as chronic inflammation and cancer. Tenascin-C interacts with several other extracellular matri...
A sticky situation: CCN1 promotes both proliferation and apoptosis of cancer cells [0.03%]
一个棘手的情况：CCN1促进癌细胞的增殖和凋亡
Andrew Leask
Andrew Leask
Members of the CCN family of matricellular signaling regulators promote cell adhesion through integrins and heparan sulfate-containing proteoglycans. A paradox of the CCN field is that, depending on the set of circumstances examined, indivi...
The interaction of Thrombospondins with extracellular matrix proteins [0.03%]
thrombospondin与细胞外基质蛋白的相互作用
Kemin Tan,Jack Lawler
Kemin Tan
The thrombospondins (TSPs) are a family of five matricellular proteins that appear to function as adapter molecules to guide extracellular matrix synthesis and tissue remodeling in a variety of normal and disease settings. Various TSPs have...
The matricellular functions of small leucine-rich proteoglycans (SLRPs) [0.03%]
小分子量亮氨酸重复蛋白聚糖(SLRPs)的细胞外基质功能
Rosetta Merline,Roland M Schaefer,Liliana Schaefer
Rosetta Merline
The small leucine-rich proteoglycans (SLRPs) are biologically active components of the extracellular matrix (ECM), consisting of a protein core with leucine rich-repeat (LRR) motifs covalently linked to glycosaminoglycan (GAG) side chains. ...
Shanna A Arnold,Rolf A Brekken
Shanna A Arnold
Although many clinical studies have found a correlation of SPARC expression with malignant progression and patient survival, the mechanisms for SPARC function in tumorigenesis and metastasis remain elusive. The activity of SPARC is context-...
Paul Bornstein
Paul Bornstein
Thrombospondins (TSPs) -1 and -2 were among the first protein inhibitors of angiogenesis to be identified, a property that was subsequently attributed to the interactions of sequences in their type I repeats with endothelial cell-surface re...
Amy D Bradshaw
Amy D Bradshaw
SPARC is a collagen-binding matricellular protein. Expression of SPARC in adult tissues is frequently associated with excessive deposition of collagen and SPARC-null mice fail to generate a robust fibrotic response to a variety of stimuli. ...
The many facets of the matricelluar protein periostin during cardiac development, remodeling, and pathophysiology [0.03%]
心脏发育、重塑及病理生理过程中的基质细胞分泌蛋白periostin的多种功能
Russell A Norris,Ricardo Moreno-Rodriguez,Stanley Hoffman et al.
Russell A Norris et al.
Periostin is a member of a growing family of matricellular proteins, defined by their ability to interact with components of the extracellular milieu, and with receptors at the cell surface. Through these interactions, periostin has been sh...
Jing Nie,E Helene Sage
Jing Nie
Adipogenesis, a key step in the pathogenesis of obesity, involves extensive ECM remodeling, changes in cell-ECM interactions, and cytoskeletal rearrangement. Matricellular proteins regulate cell-cell and cell-ECM interactions. Evidence in v...