Richard Stratton,Xu Shiwen
Richard Stratton
Fibroblasts release prostaglandins and express a range of prostanoid receptors. However the importance of prostaglandins in fibroblast biology have not been fully explored. Our studies showed that the prostaglandin metabolite PGI(2) blocks ...
Bruce L Riser,Feridoon Najmabadi,Bernard Perbal et al.
Bruce L Riser et al.
Prior work in the CCN field, including our own, suggested to us that there might be co-regulatory activity and function as part of the actions of this family of cysteine rich cytokines. CCN2 is now regarded as a major pro-fibrotic molecule ...
The lectin concanavalin-A signals MT1-MMP catalytic independent induction of COX-2 through an IKKgamma/NF-kappaB-dependent pathway [0.03%]
一种凝集素ConA通过IKKγ/NF-κB相关信号通路诱导环氧合酶-2的表达并不依赖于MT1-MMP的催化作用
Asmaa Sina,Sébastien Proulx-Bonneau,Alain Roy et al.
Asmaa Sina et al.
The lectin from Canavalia ensiformis (Concanavalin-A, ConA), one of the most abundant lectins known, enables one to mimic biological lectin/carbohydrate interactions that regulate extracellular matrix protein recognition. As such, ConA is k...
Regulation of pro-inflammatory and pro-fibrotic factors by CCN2/CTGF in H9c2 cardiomyocytes [0.03%]
CCN2/CTGF调节H9c2心肌细胞中促炎和促纤维化因子的作用
Xiaoyu Wang,Susan V McLennan,Terri J Allen et al.
Xiaoyu Wang et al.
Connective tissue growth factor (CTGF), also known as CCN2, is implicated in fibrosis through both extracellular matrix (ECM) induction and inhibition of ECM degradation. The role of CTGF in inflammation in cardiomyocytes is unknown. In som...
Thrombin-induced CCN2 expression as a target for anti-fibrotic therapy in scleroderma [0.03%]
血小板衍生生长因子诱导的CCN2表达作为硬皮病抗纤维化治疗的靶点
Andrew Leask
Andrew Leask
Scleroderma (systemic sclerosis, SSc) is a fibrotic disease for which there is no therapy. CCN2 (connective tissue growth factor, CTGF) is a marker and mediator of fibrosis. Previously, it has been shown that thrombin induces CCN2 expressio...
Connective tissue growth factor is induced in bleomycin-induced skin scleroderma [0.03%]
连接组织生长因子在博来霉素诱导的皮肤硬皮病中表达上调
Shangxi Liu,Reza Taghavi,Andrew Leask
Shangxi Liu
The origin of fibrotic cells within connective tissue is unclear. For example, the extent to which microvascular pericytes contribute to the number of myofibroblasts present in dermal fibrosis in uncertain. Connective tissue growth factor (...
The role of astrocyte-secreted matricellular proteins in central nervous system development and function [0.03%]
星形胶质细胞分泌的基质细胞因子在中枢神经系统发育和功能中的作用
Cagla Eroglu
Cagla Eroglu
Matricellular proteins, such as thrombospondins (TSPs1-4), SPARC, SPARC-like1 (hevin) and tenascin C are expressed by astrocytes in the central nervous system (CNS) of rodents. The spatial and temporal expression patterns of these proteins ...
Deadly liaisons: fatal attraction between CCN matricellular proteins and the tumor necrosis factor family of cytokines [0.03%]
致命邂逅：CCN基质蛋白与肿瘤坏死因子细胞因子家族的致死吸引力
Chih-Chiun Chen,Lester F Lau
Chih-Chiun Chen
Recent studies have revealed an unexpected synergism between two seemingly unrelated protein families: CCN matricellular proteins and the tumor necrosis factor (TNF) family of cytokines. CCN proteins are dynamically expressed at sites of in...
Thrombospondin-2 and SPARC/osteonectin are critical regulators of bone remodeling [0.03%]
血小板源性生长因子-2和SPARC/骨连素是骨重建的重要调节因子
Anne M Delany,Kurt David Hankenson
Anne M Delany
Thrombospondin-2 (TSP2) and osteonectin/BM-40/SPARC are matricellular proteins that are highly expressed by bone cells. Mice deficient in either of these proteins show phenotypic alterations in the skeleton, and these phenotypes are most pr...
Endothelin-1 as a neuropeptide: neurotransmitter or neurovascular effects? [0.03%]
内皮素-1作为神经肽：神经传递介质或神經血管效应？
Michael R Dashwood,Andrzej Loesch
Michael R Dashwood
Endothelin-1 (ET-1) is an endothelium-derived peptide that also possesses potent mitogenic activity. There is also a suggestion the ET-1 is a neuropeptide, based mainly on its histological identification in both the central and peripheral n...