Janielle Richards,Sharon Miksys,Maria Novalen et al.
Janielle Richards et al.
Cytochrome P450 2D (CYP2D) metabolises many centrally-acting substrates including opioids. Hydrocodone, an opioid and CYP2D substrate, is metabolised to hydromorphone, an active metabolite. CYP2D in the brain is active in vivo and can alter...
Usage of L-type calcium channel blockers to suppress drug reward and memory driving addiction: Past, present, and future [0.03%]
L型钙通道阻滞剂在抑制药物奖赏和记忆驱动的成瘾中的作用：过去、现在及未来展望
Hitoshi Morikawa,Cara C Young,Jasper A Smits
Hitoshi Morikawa
Over the past three decades, L-type Ca2+ channel (LTCC) blockers have been considered a potential therapeutic drug to alleviate the symptoms of drug addiction. This idea has been supported, in part, by 1) expression of LTCCs in the brain do...
Lumbrokinase regulates endoplasmic reticulum stress to improve neurological deficits in ischemic stroke [0.03%]
寡肽酶改善缺血性卒中后神经功能缺陷的机制研究
Yi-Hsin Wang,Jiuan-Miaw Liao,Ke-Min Chen et al.
Yi-Hsin Wang et al.
Ischemic stroke is characterized by the loss of cerebral blood flow, which frequently leads to neurological deficits. Tissue plasminogen activator is the only therapeutic agent approved to treat ischemic stroke but increases the risk of int...
Corticotropin releasing factor in the nucleus basalis of Meynert impairs attentional performance and reduces levels of glutamate and taurine in male and female rats [0.03%]
促肾上腺皮质激素释放因子作用于海马下托损害大鼠注意力及减少其大脑中谷氨酸和牛磺酸的水平
Samantha R Eck,Nikolaos Kokras,Brittany Wicks et al.
Samantha R Eck et al.
Psychiatric disorders that are characterized by impairments in sustained attention, including attention deficit hyperactivity disorder (ADHD), post-traumatic stress disorder (PTSD), and major depression are also sensitive to exacerbation by...
Genetic differences in nicotine sensitivity and metabolism in C57BL/6J and NOD/ShiLtJ mouse strains [0.03%]
关于C57BL/6J和NOD/ShiLtJ小鼠品系中尼古丁敏感性和代谢的遗传差异性研究
Laurel R Seemiller,Lisa R Goldberg,Phillip B Smith et al.
Laurel R Seemiller et al.
Genetic background impacts sensitivity to nicotine's rewarding and aversive effects and metabolism, which influences susceptibility to nicotine addiction. This is important because sensitivity to nicotine influences susceptibility to nicoti...
Rethinking purinergic concepts and updating the emerging role of P2X7 and P2X4 in amyotrophic lateral sclerosis [0.03%]
重新思考嘌呤能概念并更新P2X7和P2X4在肌萎缩侧索硬化症中所起的新作用
Cinzia Volonté,Susanna Amadio
Cinzia Volonté
The topic of the present review regards the ubiquitous and phylogenetically most ancient prototype of intercellular signaling, the one mediated by extracellular nucleosides and nucleotides, bearing a strong influence on pathophysiological p...
(2R,6R)-hydroxynorketamine (HNK) reverses mechanical hypersensitivity in a model of localized inflammatory pain [0.03%]
(2R,6R)-羟基nor库胺（HNK）逆转局部炎症痛模型中的机械性超敏反应
Jonathan G Yost,Caroline A Browne,Irwin Lucki
Jonathan G Yost
The ketamine metabolite (2R,6R)-hydroxynorketamine, or (2R,6R)-HNK, was recently reported to evoke antinociception in response to a noxious thermal stimulus in healthy mice and reverse mechanical hypersensitivity in a murine model of neurop...
Ping Cai,Sheng-Nan Huang,Zhi-Hui Lin et al.
Ping Cai et al.
The lateral hypothalamus (LH) is an important brain region mediating sleep-wake behavior. Recent evidence has shown that astrocytes in central nervous system modulate the activity of adjacent neurons and participate in several physiological...
Neuropeptide S facilitates extinction of fear via modulation of mesolimbic dopaminergic circuitry [0.03%]
神经肽S通过调节中脑边缘多巴胺通路促进恐惧的消退作用
Harish M Kawade,Sanjay N Awathale,Nishikant K Subhedar et al.
Harish M Kawade et al.
The inability to extinguish learned fear is a hallmark of trauma- and stress-related disorders. A form of inhibitory learning called fear extinction is an effective way to treat these disorders. However, the neurobiology of fear extinction ...
Psychedelics therapeutics: What we know, what we think, and what we need to research [0.03%]
致幻剂治疗：我们所知的、我们认为的以及我们需要研究的
David Nutt,Meg Spriggs,David Erritzoe
David Nutt
Psychedelic therapy is perhaps the most exciting new development in psychiatry. Not only does it offer a radical new approach to treatment where mainstream approaches have proven ineffective, but the growing evidence for transdiagnostic eff...