Central role of purinergic receptors with inflammation in neuropathic pain-related macrophage-SGC-neuron triad [0.03%]
嘌呤受体在神经病理性疼痛相关巨噬细胞-星形胶质细胞-神经元三联体中的关键作用
Runan Yang,Junpei Du,Lin Li et al.
Runan Yang et al.
Adenosine triphosphate (ATP) acts on P2 purinergic receptors as an extracellular signaling molecule. P2 purinergic receptors include P2X ionotropic receptors and P2Y metabotropic receptors. Satellite glial cells (SGCs) and macrophages expre...
Gut microbes and host behavior: The forgotten members of the gut-microbiome [0.03%]
肠道微生物与宿主行为：被遗忘的肠道微生物组成员
Ariel Weiner,Sondra Turjeman,Omry Koren
Ariel Weiner
The gut microbiota refers to an entire population of microorganisms that colonize the gut. This community includes viruses, prokaryotes (bacteria and archaea), and eukaryotes (fungi and parasites). Multiple studies in the last decades descr...
Binding preference at the μ-opioid receptor underlies distinct pharmacology of cyclopropyl versus valeryl analogs of fentanyl [0.03%]
环丙基与戊基芬太尼类似物在μ-阿片受体上的不同药理作用源自于其结合偏好性差异
Bing Xie,Valerie P Le Rouzic,Alexander Goldberg et al.
Bing Xie et al.
Illicitly manufactured fentanyl is driving the current opioid crisis, and various fentanyl analogs are appearing in recreational drug markets worldwide. To assess the potential health risks posed by fentanyl analogs, it is necessary to unde...
Characterisation of the neural basis underlying appetitive extinction & renewal in Cacna1c rats [0.03%]
Cacna1c基因敲除小鼠的食欲剥夺及复现的神经基础研究
Patricia Gasalla,Denise Manahan-Vaughan,Dominic Michael Dwyer et al.
Patricia Gasalla et al.
Recent studies have revealed impairments in Cacna1c ± heterozygous animals (a gene that encodes the Cav 1.2 L-type voltage-gated calcium channels and is implicated in risk for multiple neuropsychiatric disorders) in aversive forms of learn...
The high frequency oscillation in orbitofrontal cortex is susceptible to phenethylamine psychedelic 25C-NBOMe in male rats [0.03%]
25C-NBOMe苯乙胺类致幻剂通过作用于眶额皮层高频振荡而影响雄性大鼠行为反应模式
Zhi-Peng Yu,Qiong Li,Zhou-Xiao Wu et al.
Zhi-Peng Yu et al.
Serotoninergic psychedelics induced extensive alterations in perception and cognition, which has been attributable to its disruptive effect on oscillatory rhythms of prefrontal cortex. However, there is a lack of information how serotoniner...
Selective M5 muscarinic acetylcholine receptor negative allosteric modulator VU6008667 blocks acquisition of opioid self-administration [0.03%]
选择性M5胆碱能受体拮抗剂VU6008667可阻断阿片类药物的自我给药行为
Laura B Teal,Michael Bubser,Edith Duncan et al.
Laura B Teal et al.
Recent evidence suggests that inhibition of the M5 muscarinic acetylcholine receptor (mAChR) may provide a novel non-opioid mechanism for the treatment of opioid use disorder (OUD). Previous studies from our group and others have demonstrat...
Group II metabotropic glutamate receptor activation suppresses ATP currents in rat dorsal root ganglion neurons [0.03%]
_group II 代谢型谷氨酸受体激活抑制大鼠背根神经节神经元的 ATP 流量_
Wen-Long Qiao,Qing-Rui Qin,Qing Li et al.
Wen-Long Qiao et al.
P2X3 receptors and group II metabotropic glutamate receptors (mGluRs) have been found to be expressed in primary sensory neurons. P2X3 receptors participate in a variety of pain processes, while the activation of mGluRs has an analgesic eff...
miR-9a-5p expression is decreased in the hippocampus of rats resistant to lamotrigine: A behavioural, molecular and bioinformatics assessment [0.03%]
拉莫三嗪抗性大鼠海马区miR-9a-5p表达降低：行为学、分子及生物信息学评估
Natalia Chmielewska,Adriana Wawer,Zofia Wicik et al.
Natalia Chmielewska et al.
The major obstacle in developing new treatment strategies for refractory epilepsy is the complexity and poor understanding of its mechanisms. Utilizing the model of lamotrigine-resistant seizures, we evaluated whether changes in the express...
Endomorphin analog ZH853 shows low reward, tolerance, and affective-motivational signs of withdrawal, while inhibiting opioid withdrawal and seeking [0.03%]
恩多腓肽类似物ZH853表现出较低的奖赏、耐受性和情感动机戒断症状，同时抑制阿片类药物的戒断和渴求反应
Ariel T Amgott-Kwan,James E Zadina
Ariel T Amgott-Kwan
Currently available μ-opioid receptor agonist pharmacotherapies for opioid use disorder possess adverse effects limiting their use and, despite treatment, rates of relapse remain high. We previously showed that endomorphin analog ZH853 had...
Inhibition of RPTPβ/ζ reduces chronic ethanol intake in adolescent mice and modulates ethanol effects on hippocampal neurogenesis and glial responses in a sex-dependent manner [0.03%]
RPTPβ/ζ抑制减少小鼠青春期饮酒并以性别依赖的方式调节乙醇对海马神经发生和胶质细胞反应的影响
Milagros Galán-Llario,María Rodríguez-Zapata,Teresa Fontán-Baselga et al.
Milagros Galán-Llario et al.
Pleiotrophin (PTN) is a cytokine that modulates ethanol drinking and reward and regulates glial responses in different contexts. PTN is an inhibitor of Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ. Inhibition of RPTPβ/ζ reduces bing...