Receptor-specific noradrenergic modulation of oscillatory dynamics during non-rapid eye movement sleep in adult male rats [0.03%]
成人雄性大鼠非快速眼动睡眠期间特异性受体noradrenergic振荡动力学调节
Ernesto Durán,Yulia Novitskaya,Oxana Eschenko
Ernesto Durán
Cortical slow oscillations (SO, ∼1 Hz), which are hallmarks of non-rapid eye movement (NREM) sleep, temporally organize thalamocortical spindles (10-16 Hz) and hippocampal ripples (∼150 Hz), thereby promoting coordinated activity within t...
UDPG/P2Y14-STAT1 axis mediates LPS-induced reactive astrogliosis [0.03%]
UDPG/P2Y14-STAT1轴介导LPS诱导的反应性星形胶质细胞活化
Meng-Yao Wang,Yuan-Hong Deng,Xiao-Feng Ran et al.
Meng-Yao Wang et al.
Astrocytes play a vital role in neuroinflammatory processes within the central nervous system (CNS). Increasing evidence suggests that purinergic G protein-coupled receptor P2Y14 is associated with neuroinflammation. However, the expression...
Tiagabine and Brivaracetam combination rewire epileptic activity in kainic acid-induced temporal lobe epilepsy model: Multimodal analysis of EEG spectra, behavior and neuroinflammatory modulation [0.03%]
替加宾和布瓦西坦组合可重构卡尼酸诱导的颞叶癫痫模型中的痫样活动：EEG谱、行为以及神经炎症调制的多模式分析
Sana Javaid,Zohabia Rehman,Abida Parveen et al.
Sana Javaid et al.
Temporal lobe epilepsy is a pharmacoresistant neurological disorder associated with neurobehavioral comorbidities in which existing monotherapies prove insufficient to halt epileptogenesis and preserve neurological function. The present stu...
GluN2B in the dorsal hippocampus is involved in the regulation of hippocampus-dependent memory in Parkinsonian rats [0.03%]
背侧海马区的GluN2B参与调节帕金森病大鼠海马依赖性记忆功能
Xiang Wu,Yanping Hui,Ling Wang et al.
Xiang Wu et al.
Cognitive impairment is one of the most common non-motor symptoms of Parkinson's disease (PD), which occurs even at an early stage and progresses over time. The hippocampus is involved in PD-related cognitive impairment and expresses abunda...
Neurotoxic effects of chronic ethanol on cholinergic interneurons in the dorsomedial striatum [0.03%]
慢性酒精对腹侧纹状体胆碱能中间神经元的神经毒性作用
Logan E Slade,Charles C Levy,Jacob T Mitcham et al.
Logan E Slade et al.
Alcohol use disorder (AUD) has severe adverse health and economic impacts totaling over $240 billion in the U.S. annually. Despite this, FDA approved treatments for AUD are limited, thus, further understanding of the neurobiological mechani...
Projections from prefrontal cortex to dorsal hippocampus mediate lipopolysaccharide induced recognition memory deficits in mice [0.03%]
前额皮层至海马脑区投射介导了脂多糖所致小鼠识别记忆障碍
Xin-Yu Zhao,Jie Han,Xin-Yi Cheng et al.
Xin-Yu Zhao et al.
Background: s: Neuroinflammation plays a critical role in the development of cognitive impairment observed in postoperative patients. Meanwhile, the prefrontal cortex (PFC) and hippocampus are core brain regions that medi...
Central and peripheral monoamine changes in a rat model of Gaming Disorder [0.03%]
游戏障碍大鼠模型中枢和外周单胺变化规律研究
Antonino Casile,Brigitta Bonaldo,Martina Bettarelli et al.
Antonino Casile et al.
Gaming Disorder (GD) is a mental disorder primarily affecting adolescents. Prolonged video game use can lead to behavioral alterations, such as loss of control, increased compulsivity, and symptoms of depression and anxiety. Studies in huma...
Modulation of cellular and mitochondrial dysfunction by TRPV4 during early stages of Vincristine-induced neurotoxicity in cultured neuronal model [0.03%]
瞬时受体电位香草素亚型4通道调节长春新碱诱导的培养神经元模型早期毒性作用中的细胞及线粒体功能障碍
Nilesh Kumar Das,Sushama Mohanta,Tanishaa Aswin et al.
Nilesh Kumar Das et al.
Intracellular and mitochondrial Ca2+ play pivotal role in chemotherapeutics-induced toxicity. Here, we show that TRPV4, a thermosensitive ion channel implicated in pain, modulates mitochondrial Ca2+, ROS and temperature during chemotherapeu...
5-Lipoxygenase triggers depressive-like behaviors via activating NLRP3-induced pyroptosis in CUMS-exposed mice [0.03%]
5-脂氧合酶通过激活NLRP3诱导的细胞焦亡触发慢性不可预知性温和应激刺激的小鼠产生类似抑郁的行为
Yani Zhang,Zheng Yang,Ting Xu et al.
Yani Zhang et al.
5-Lipoxygenase (5-LOX) is implicated the pathogenesis of depression, yet the underlying molecular mechanism remains unclear. In our study, we investigated the dynamic changes of 5-LOX expression after chronic unpredictable mild stress (CUMS...
Astrocytic Connexin43 in Alzheimer's disease: mechanisms, interaction with P2 receptors, and therapeutic potential [0.03%]
阿尔茨海默病中的星形胶质细胞Connexin43：机制、与P2受体的相互作用及其治疗潜力
Weijie Xiong,Yixun Su,Alexei Verkhratsky et al.
Weijie Xiong et al.
Pathogenesis of Alzheimer's disease (AD) is closely linked to functional abnormalities of the gap junction protein Connexin43 (Cx43) in astrocytes. Cx43 mediates ion homeostasis, metabolic support, and glial network signalling through forma...