Nicotine produces a sex- and subregion-specific hypoglutamatergic state in rodent amygdala which can be reversed by motor-skill training [0.03%]
尼古丁通过特定性别和亚区的方式在啮齿动物杏仁体内产生低谷氨酸盐状态，运动训练可以逆转该现象
Erika Lucente,Ana Domi,Mia Ericson et al.
Erika Lucente et al.
Nicotine abstinence is associated with negative affect and a high risk of relapse, but the neurophysiological underpinnings have not been fully outlined. Considering the role of the amygdala in emotional processing and stress regulation, ch...
TAAR1 activation normalizes dopamine signaling and decreases alcohol intake in SRKO mice after adolescent ethanol exposure [0.03%]
TAAR1激活可调节青少年酒精暴露后的成年小鼠多巴胺信号并减少酒精摄入量
Charles Houdant,Cassandre Rouanet,Valentine Bouet et al.
Charles Houdant et al.
Glutamatergic and dopaminergic dysregulations are major features of alcohol use disorder (AUD). The trace amine-associated receptor 1 (TAAR1), which modulates both systems, has emerged as a promising therapeutic target, although the underly...
Pyk2-PSD95 Activation alleviates cognitive dysfunction by modulation of hippocampal synaptic structural plasticity via NMDAR2A in mice with neuropathic pain [0.03%]
活化Pyk2-PSD95通过NMDAR2A调节海马区突触结构可塑性来缓解神经病理性疼痛小鼠的认知功能障碍
Qingbiao Song,Yijia Zhang,Zhiyu Zhang et al.
Qingbiao Song et al.
Neuropathic pain is frequently accompanied by cognitive impairments, which exacerbate the quality of life for chronic pain patients. Previous studies have demonstrated that the hippocampus as a key region involved in cognitive dysfunction. ...
Ivermectin Reduces Withdrawal-Induced Alcohol Intake in Rats: Association with CeA GABAergic Enhancement and P2rx4 Genetic Liability [0.03%]
伊维菌素可降低大鼠因戒断导致的酒精摄入量：与CeA中GABA能增强和P2rx4遗传易感性相关性研究
Paola Campo,Ran Qiao,Michelle R Doyle et al.
Paola Campo et al.
Although FDA-approved medications for alcohol use disorder are available, their efficacy varies across patients, highlighting the need for novel therapeutics that address inter-individual differences in disease etiology and treatment respon...
Association of stress-sensitive mid-insula activity with alcohol drinking and negative affect-like behavior during abstinence in mice [0.03%]
小鼠戒酒期间应激敏感的岛叶皮层中段活动与饮酒和负性情绪行为的关系
Benjamin M Williams,Jincy R Little,Samuel W Centanni
Benjamin M Williams
Stress is central to many neuropsychiatric conditions, including alcohol use disorder (AUD). Stress influences alcohol initiation, escalation, progression to AUD, and relapse. Identifying stress-activated neurocircuits and individual variab...
Alex Conibear,Chris P Bailey,Eamonn Kelly
Alex Conibear
Victoria Maneu,Antonio G García
Victoria Maneu
In this review we explore the potential of P2X7 receptor blockers to elicit neuroprotection. This conjecture is based on a reasonably well-established role of this receptor in activating glial cells to maintain a chronic low-level neuroinfl...
N,N-dimethyltryptamine (DMT) is neither formed nor retained in serotonin terminals in the rat brain [0.03%]
N,N-二甲基色胺(DMT)不在大鼠脑内形成或蓄积于五羟色胺神经末梢之内
Mikael Palner,Elisabeth Kolesnik,Christina Baun et al.
Mikael Palner et al.
Mammalian brain may contain an endogenous pool of the psychedelic substance N,N-dimethyltryptamine (DMT), which may act as a co-transmitter with serotonin (5-HT). We tested the joint hypotheses. We tested the joint hypotheses that endogenou...
The Neuronal P2X7R Controversy: Revisiting Evidence, Methods, and Unresolved Questions [0.03%]
神经P2X7受体争议：重新审视证据、方法和未决问题
Neha Kachappilly,Paola Pizzo,Emy Basso
Neha Kachappilly
The P2X7 receptor (P2X7R) is an ATP-gated ion channel belonging to the purinergic ligand-gated P2X receptor family. In the central nervous system (CNS), activation of this receptor has been proposed to play a key role in the pathogenesis of...
Indole-3-propionic acid inhibits astrocyte inflammation and promotes motor function recovery after spinal cord injury via the AhR/NF-κB/MAPK axis [0.03%]
吲哚-3-丙酸通过AhR/NF-κB/MAPK轴抑制星形胶质细胞炎症并促进脊髓损伤后的运动功能恢复
Dapeng Yu,Jianning Kang,Wei Jiang et al.
Dapeng Yu et al.
Spinal cord injury (SCI) triggers persistent neuroinflammation, primarily driven by aberrant astrocyte activation, which exacerbates secondary neurodegeneration. Indole-3-propionic acid (IPA), a tryptophan-derived metabolite produced by the...