Adolescent cannabinoid vapour exposure sex-dependently alters the relationship between vulnerability traits and ethanol self-administration and modifies naltrexone actions on ethanol intake in rats [0.03%]
青春期大麻素气溶胶暴露性别依赖性地改变了易感特征与酒精自给之间的关系，并且会改变纳曲酮对酒精摄入的作用
Jairo S Acosta-Vargas,Natalia de Las Heras-Martínez,Alberto Marcos et al.
Jairo S Acosta-Vargas et al.
Cannabis use during adolescence is common and may predispose individuals to substance use disorders. Animal studies have explored the gateway hypothesis, but data on ethanol consumption are limited. This study aimed to investigate the poten...
Psilocin mediates long-term synaptic depression in the prelimbic cortex through 5-HT2A receptor-independent mechanisms [0.03%]
裸盖菇素通过5-HT2A受体非依赖途径介导前扣带回皮层的长期突触抑制
Ana Domi,Erika Lucente,Davide Cadeddu et al.
Ana Domi et al.
Psilocybin is a naturally occurring psychedelic compound with potential antidepressant effects. Although it has long been used by humans, primarily for recreational purposes, the molecular mechanisms underlying its actions remain incomplete...
Ivabradine reduces seizure susceptibility in a genetic model of mixed epilepsies [0.03%]
伊伐布雷定可减少遗传性癫痫发作易感性模型中的癫痫发作发生率
Gleice Kelli Silva-Cardoso,Prosper N&#x;Gouemo
Gleice Kelli Silva-Cardoso
Ivabradine is an approved medication that lowers heart rate by inhibiting hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, which are critical regulators of neuronal excitability. This study investigated the effects of iva...
The novel PSD-95 inhibitor BXOS110 provides neuroprotection in acute ischemic stroke [0.03%]
新型PSD-95抑制剂BXOS110可改善急性缺血性脑卒中神经功能损伤
Huan-Yu Zheng,Ya-Rong Ding,Fei-Yang Guo et al.
Huan-Yu Zheng et al.
Acute ischemic stroke remains a major public health challenge due to its high incidence and limited effective treatment options. Reperfusion therapies, including thrombolysis and endovascular intervention, help restore blood flow in some pa...
The interaction between FLOT1 and FOSL2 promotes EphA2 transcription, regulating microglial polarization and affecting neuroinflammation in Alzheimer's disease [0.03%]
FLOT1与FOSL2的互作通过促进EphA2转录调节小胶质细胞活化影响阿尔茨海默病神经炎症响应机制研究
Biyan Li,Jiangxi Xu,Hong Zhu et al.
Biyan Li et al.
Background: Microglial activation plays a crucial role in Alzheimer's disease (AD), responding to amyloid-beta (Aβ) plaques and tau tangles. Initially protective, microglia clear Aβ deposits and support neuronal health,...
The frequency of binge-like ethanol exposure bidirectionally regulates hippocampal mGlu-LTD via synaptic mechanisms and this effect is reversed by minocycline [0.03%]
类似乙醇滥用的高频率或低频率暴露通过突触机制双向调节海马mGlu LTD，且四环素类抗生素能逆转其影响
M Debris,C Deschamps,M Martin et al.
M Debris et al.
Alcohol addiction may begin in young adults through binge drinking (BD) with its frequency as key criterion. In rodents, BD impairs memory and hippocampal synaptic plasticity on the short term and induced neuroinflammation. Memory impairmen...
Electrocorticographic, Astrocytic and Transcriptomic Signatures in the Triple Transgenic Mouse Model of Alzheimer's Disease submitted to Stearoyl-CoA Desaturase Inhibition [0.03%]
阿尔兹海默病三联转基因小鼠经硬脂酰辅酶A去饱和酶抑制处理的电生理、星形胶质细胞及转录组特征分析
Audrey Hector,Tanya Leduc,Maria João da Costa Caiado et al.
Audrey Hector et al.
Alzheimer's disease (AD) is associated with cognitive deficits and sleep disturbances. Research suggests the involvement of dysfunctions in lipid metabolism in the brain of AD patients and animal models. The inhibition of stearoyl-CoA desat...
Lactate-driven H3K27 lactylation promotes Olig2-dependent remyelination and motor recovery after spinal cord injury [0.03%]
乳酸驱动的H3K27乳酰化促进脊髓损伤后的Olig2依赖性脱髓鞘和运动功能恢复
Zongxin Zhu,Ximiao Chen,Hanwen Zhang et al.
Zongxin Zhu et al.
Demyelination caused by oligodendrocyte death is a key contributor to neurological deficits after spinal cord injury (SCI), highlighting the critical need to promote oligodendrocyte precursor cell (OPC) differentiation and remyelination. Th...
Assessing the utility of the neurosteroid zuranolone to modify alcohol-related behaviours [0.03%]
评估神经类固醇zuranolone在调节与酒精相关行为方面的效用
Lauren T Ursich,Amy J Pearl,Xavier J Maddern et al.
Lauren T Ursich et al.
Alcohol use is a leading risk factor for premature mortality, yet effective pharmacotherapies remain limited. Neurosteroids, such as allopregnanolone, modulate γ-aminobutyric acid type A (GABAA) receptors and influence alcohol-related beha...
Brain-penetrant microtubule-stabilizer epothilone B delays isoflurane-induced unconsciousness in mice [0.03%]
脑渗透性微管稳定剂埃坡霉素B延迟异氟醚诱导的小鼠昏迷
Yixiang Huang,Zitong Qiu,Xinyue Yu et al.
Yixiang Huang et al.
Inhalational anesthetics are currently believed to cause unconsciousness by acting on multiple molecular targets including neural ion channels, receptors, mitochondria, synaptic proteins, and cytoskeletal proteins. Inhalational anesthetics ...