Analysis of bitter compounds in traditional preparations of Gentiana purpurea L [0.03%]
紫花龙胆传统用法中苦味成分分析
Håvard Hoel,Hugo J de Boer,Anneleen Kool et al.
Håvard Hoel et al.
Roots of Gentiana purpurea are known to have an intense bitter taste due to its high content of secoiridoids. In folk medicine roots have commonly been prepared as water decoctions, soaked in ethanol, or boiled with milk, wine, or beer. The...
Toonanoronoids A-E, five new limonoids from Toona ciliata var. yunnanensis [0.03%]
云南楠五个新的芸香苷类化合物（屯安若诺红素A-E）
Wei-Hua Wang,Wei Yang,Jin-Run Dong et al.
Wei-Hua Wang et al.
Five new B-seco-limonoids, namely toonanoronoids A-E (1-5), in conjunction with three previously reported compounds, were isolated from the EtOAc extract of the twigs and leaves of Toona ciliata var. yunnanensis. Their structures were eluci...
QSAR prediction, synthesis, anticancer evaluation, and mechanistic investigations of novel sophoridine derivatives as topoisomerase I inhibitors [0.03%]
基于拓扑异构酶I抑制剂的新Sophoridine衍生物的QSAR预测、合成、抗肿瘤评价及机制研究
Lin Zhu,Yongle Yu,Youfu Ma et al.
Lin Zhu et al.
Sophoridine, which is derived from the Leguminous plant Sophora alopecuroides L., has certain pharmacological activity as a new anticancer drug. Herein, a series of novel N-substituted sophoridine derivatives was designed, synthesized and e...
Zongzhou Song,Wenquan Li,Qingying He et al.
Zongzhou Song et al.
Keloids are prevalent pathological scars, often leading to cosmetic deformities and hindering joint mobility.They cause discomfort, including burning and itching, while gradually expanding and potentially posing a risk of cancer.Developing ...
Biochemical and toxicity evaluation of Retama sphaerocarpa extracts and in-silico investigation of phenolic compounds as potential inhibitors against HPV16 E6 oncoprotein [0.03%]
Retama sphaerocarpa提取物的生化、毒性评价及酚类化合物抑制HPV16 E6致癌蛋白的虚拟筛选研究
Soumia Moujane,Ismail Bouadid,Aziz Bouymajane et al.
Soumia Moujane et al.
Cervical cancer is a type of cancer which affects the cervix cells. The conventional treatments for cervical cancer including surgery, chemotherapy, and radiotherapy are only effective in premature stages and less effective in late stages o...
Two new quinoline alkaloid with neuroprotective activities from Xylaria longipes [0.03%]
Xylaria长枝素中的两个新的具有神经保护作用的喹啉类生物碱
Tao-Hai Liu,Xia Xu,Lan-Qing Li et al.
Tao-Hai Liu et al.
Two new quinoline alkaloids with an α, β-unsaturated amide side chain, xylarinines A and B (1 and 2), were isolated from the ethyl acetate extracts of Xylaria longipes solid fermentation. The structures of these were primarily determined ...
Phytochemical analysis and biological activities of the aerial parts of Odontites vulgaris Moench [0.03%]
奥ndonites vulgaris莫内的地上部分的植物化学分析及生物活性研究
Claudio Frezza,Daniela De Vita,Alessandro Venditti et al.
Claudio Frezza et al.
In this work, the first specific phytochemical analysis on Odontites vulgaris Moench collected in Central Italy was performed. The aerial parts ethanolic extract was studied and eight compounds were identified: pheophytin a (1), aucubin (2)...
Bioactive alkaloidal and phenolic phytochemicals as promising epidrugs for diabetes mellitus 2: A review of recent development [0.03%]
生物碱和酚类植物化学物作为治疗2型糖尿病表观遗传药物的前景：近期研究进展综述
Yusuf Oloruntoyin Ayipo,Chien Fung Chong,Hassan Taiye Abdulameed et al.
Yusuf Oloruntoyin Ayipo et al.
Type 2 diabetes (T2D) remains a major chronic metabolic disorder affecting hundreds of millions of the global population, mostly among adults, engendering high rates of morbidity and mortality. It is characterized by complex aetiologies inc...
Network pharmacology and experimental insights into STAT3 inhibition by novel isoxazole derivatives of piperic acid in triple negative breast cancer [0.03%]
新型胡椒酸异噁唑衍生物通过STAT3抑制三阴性乳腺癌的网络药理学和实验研究见解
G N Yatoo,Basharat A Bhat,Zubaid-Ul-Khazir et al.
G N Yatoo et al.
STAT3 is a crucial member within a family of seven essential transcription factors. Elevated STAT3 levels have been identified in various cancer types, notably in breast cancer (BC). Consequently, inhibiting STAT3 is recognized as a promisi...
Determination of α-Dicarbonyl compounds in traditional Chinese herbal medicines [0.03%]
传统中药中α-二羰基化合物的测定
Yang Yang,Hai-Ling Wang,Rui-Tong Cheng et al.
Yang Yang et al.
α-DCs (α-dicarbonyls) have been proven to be closely related to aging and the onset and development of many chronic diseases. The wide presence of this kind of components in various foods and beverages has been unambiguously determined, b...