Anti-inflammatory polyketides from the endophytic fungus Talaromyces aculeatus A884 [0.03%]
内生真菌Talaromyces aculeatus A884的抗炎多聚酮类化合物
Jianpeng Zhang,Chunan Li,Yuchan Chen et al.
Jianpeng Zhang et al.
Chemical investigation on the EtOAc extract of endophytic fungus Talaromyces aculeatus A884 led to the isolation of one undescribed γ-butyrolactone aculeatone A (1), one rubralactone aculeatone B (2), and one polyester aculeatone C (5) tog...
Investigation of Kai-Xin-San in alleviating cognitive impairment in aβ transgenic Caenorhabditis elegans through mitochondrial function regulation [0.03%]
开心散通过调节线粒体功能改善阿尔茨海默病秀丽隐杆线虫模型认知障碍的机制研究
Dalong Li,Ao Xue,Yujia Guan et al.
Dalong Li et al.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline, mitochondrial dysfunction, and amyloid β-protein (Aβ) accumulation, with limited safe and effective treatments available. Kai-Xin-San...
Identification of oligopeptide components derived from Pseudostellaria heterophylla and its hypoglycemic effects in streptozotocin-induce type 2 diabetes mice [0.03%]
基于异株剪秋罗寡肽组分的降糖活性成分筛选及作用机制研究
Yingnan Chen,Xiangwei Qu,Xingliang Xiang et al.
Yingnan Chen et al.
Background: Low molecular weight oligopeptides have attracted extensive attention in peptide-based diabetes treatment due to their high selectivity, low toxicity, reduced immunogenicity, and favorable therapeutic effect. ...
Six undescribed geranylated flavonoid derivatives isolated from Macaranga denticulata with potent Zika virus inhibitory activity [0.03%]
6种新木姜叶树Macaranga denticulata牻牛儿基黄酮衍生物及其抗寨卡病毒活性
Jia-Bi Huang,Yong-Xiang Huang,Meng-Ru Wang et al.
Jia-Bi Huang et al.
Six undescribed geranylated flavonoid derivatives (1-6), together with two known compounds (7-8), were isolated from Macaranga denticulata Müll. Arg. (family Euphorbiaceae). Their structures were characterized by detailed spectroscopic ana...
Acmella uliginosa (Sw.) Cass hampers complete Freund's adjuvant-induced arthritis in rats by inhibiting the VEGF axis [0.03%]
湿生独活素抑制血管内皮生长因子信号轴抗完全弗氏佐剂型类风湿关节炎作用研究
Baizura Mohd Borhan,Wan Aimi Faqiehah Wan Mohd Fadzil,Joan Blin et al.
Baizura Mohd Borhan et al.
Rheumatoid arthritis (RA), which is characterized by joint inflammation, is associated with excessive angiogenesis. Acmella uliginosa (Sw) Cass, known as "Subang nenek" in Malaysia, is traditionally used for various inflammatory conditions....
Integrated network pharmacology and therapeutic verification of Dendrobium officinale flower on primary dysmenorrhea via inhibition of the TLR4/NF-κB/COX-2 pathway [0.03%]
基于TLR4/NF-κB/COX-2信号通路的石斛花治疗原发性痛经的网络药理学及实验验证
Manman Li,Pei Sheng,Weiqing Shi et al.
Manman Li et al.
Dendrobium officinale flowers (DOF) offer a wide range of therapeutic benefits due to their rich content of bioactive compounds. Traditionally used in Chinese medicine, these flowers are valued for their health benefits, including anti-infl...
Isolation, structural characterization, anti-tumor activity, and mechanisms of novel compounds from the roots of Aconitum pendulum Busch [0.03%]
基于Aconitum pendulum Busch根的抗癌先导化合物的分离鉴定及其机制研究
Xiaojing Li,Jieshu Li,Hao Liu et al.
Xiaojing Li et al.
Twelve compounds were isolated from the roots of Aconitum pendulum Busch, including a novel alkaloid (compound 1) and a new lignan (compound 2), along with ten known compounds. Activity studies demonstrated that compound 2 exhibited the mos...
H19/miRNA-675 axis: a possible new strategy to alleviate pulmonary vascular remodelling in COPD by Qibai Pingfei Capsule [0.03%]
气败平肺胶囊通过H19/miRNA-675轴可能成为缓解慢性阻塞性肺疾病肺血管重构的新策略
Jinghui Xie,Siyu Tang,Huan Wu et al.
Jinghui Xie et al.
Chronic obstructive pulmonary disease (COPD) poses a significant socio-economic and health burden. Long-term hypoxia-induced pulmonary vascular remodelling serves as a critical pathological basis of COPD. Hypoxia is known to elevate long no...
Cadinane sesquiterpenes from Alangium platanifolium: structural elucidation and anti-colorectal cancer biological evaluation [0.03%]
Alangium platanifolium中的卡迪烷倍半萜：结构解析和抗结直肠癌生物活性评价
Kang-Yun Jiang,Hao Zhang,Ya-Nan Du et al.
Kang-Yun Jiang et al.
A total of thirteen cadinane sesquiterpenes, including three previously undescribed compounds (1-3) and ten known analogues (4-13), were isolated from the roots of Alangium platanifolium through various phytochemical separation techniques, ...
I A Khabarov,S D Sergazy,A Amanzhan et al.
I A Khabarov et al.
Currently, the attention of researchers is attracted by natural polyphenolic compounds, including flavonoids, which exhibit pronounced antioxidant, anti-inflammatory, and antitumor properties. More than 8500 phenolic compounds have been iso...