Guided discovery of anti-hyperuricemic active molecules from Dioscorea septemloba by activity labelled molecular networking [0.03%]
基于活性导向的分子网络引导法发现薯蓣七叶胆抗高尿酸活性成分及机制研究
Jinqian Yu,Lei Zhao,Zhenqiang Wang et al.
Jinqian Yu et al.
Six new molecules (1-6) were obtained from the rhizomes of Dioscorea septemloba according to the ALMN workflow showed anti-hyperuricemic activity. The constructed ALMN could clearly visualize the activities and the structure nodes, which ca...
Isolation, structural characterization, molecular docking and hypoglycemic activities of an arabinose- and galactose-rich polysaccharide from Rehmannia glutinosa [0.03%]
地黄中富含阿拉伯糖和半乳糖多糖的分离、结构表征、分子对接及降血糖活性研究
Qian Zeng,Zheyuan Liu,Wenxing Ao et al.
Qian Zeng et al.
Rehmannia glutinosa, a widely used traditional Chinese medicinal herb and dietary therapeutic, is rich in polysaccharides. In this experiment, column chromatography was employed to separate and purify the polysaccharides from Rehmannia glut...
C-29 functionalization of maytenoic acid from Salacia chinensis for anticancer activity against skin melanoma [0.03%]
基于卫矛酸的抗癌药物前体候选物的设计、合成及评价皮肤黑色素瘤细胞活性研究
Swapna Rao,Namballa Hemalatha,Sushmitha Panaganti et al.
Swapna Rao et al.
Phytochemical investigations and isolation of molecules from the seeds of Salacia chinensis were carried out for the first time, and the major compound was structurally elucidated as maytenoic acid (polpunonic acid). The compound was furthe...
Therapeutic potential of α-santalol: Sources, mechanisms, and anti-tumor prospects [0.03%]
α-檀醇的治疗潜力：来源、机制与抗肿瘤前景
Ruijun Wang,Guanyu Shi,Yunling Liu et al.
Ruijun Wang et al.
Α-santalol, a naturally occurring sesquiterpene and a primary constituent of sandalwood oil, exhibits significant potential as an antitumor agent due to its diverse biological activities. Derived mainly from Santalum species like Santalum ...
Insight into enhancing effect and mechanism of three Chinese herbal extracts on proliferation and lactation performance of canine and feline mammary epithelial cells [0.03%]
三种中药提取物对犬猫乳腺上皮细胞增殖及泌乳性能的影响与机制初探
Tong Liu,Huasong Bai,Hengyan Wang et al.
Tong Liu et al.
Mammal animals have the problem of insufficient breast milk. Medicago sativa L., Eucommia ulmoides Oliv. and Perilla frutescens (L.) Britton are potential plants with improving milk function and raising the milk yield. In this study, based ...
UHPLC-MS/MS-guided profiling and bioactivity screening of Papaver apokrinomenon extracts: Insights into alkaloid- and phenolic-driven health effects [0.03%]
基于UHPLC-MS/MS指导的Papaver apokrinomenon提取物特征及生物活性筛选：碱性和酚类驱动健康效应的新见解
Shakeel Ahmed,Gunes Ak,Enver Saka et al.
Shakeel Ahmed et al.
Papaver species are widely known for their remarkable ability to produce a diverse array of secondary metabolites, notably alkaloids. Among them, P. apokrinomenon stands out as a significant species, yet its chemical profile and biological ...
Liangxue Huoxue decoction protects against sepsis-induced acute lung injury by restoring gut microbiota and inhibiting inflammation and oxidative stress via the SIRT1/NF-κB/Nrf2 signaling pathway [0.03%]
凉血活血汤通过SIRT1/NF-κB/Nrf2信号通路恢复肠道菌群平衡及抑制炎性反应和氧化应激从而保护内毒素诱导的急性肺损伤
Chengliang Zhong,Zhe Sun,Dihua Li et al.
Chengliang Zhong et al.
Liangxue Huoxue decoction(LXHX) is an effective empirical traditional Chinese medicine prescription,which has been clinically used for abdominal infectious disease for many years in Tianjin Nankai Hospital.Acute lung injury (ALI) is a sever...
Shengmaisan combined with Liuwei Dihuang Decoction alleviated CIH-induced glutamate excitotoxicity by IGF1/IGFR signaling pathway [0.03%]
圣玛散联合六味地黄汤通过胰岛素样生长因子1/胰岛素样生长因子1受体信号通路缓解慢性不可预见性温和应激诱导的谷氨酸兴奋毒性
Xue Chen,Xintong Fan,Qingqing Liu et al.
Xue Chen et al.
Background: Chronic intermittent hypoxia (CIH) is the primary pathological feature of obstructive sleep apnea (OSA), and plays a key role in glutamate excitotoxicity-induced cognitive impairment. ...
Canlucones A-I from the whole plant of Canscora lucidissima exhibit anti-inflammatory and antitumor activities [0.03%]
新颖倍半萜_canlucone A-I_的抗炎及抗肿瘤活性研究
Meng-Yu Zhang,Jiao Liu,Xue-Ting Cui et al.
Meng-Yu Zhang et al.
Nine undescribed xanthones (1-9), named canlucones A-I, along with eleven known analogues (10-20), were isolated from the whole plants of Canscora lucidissima. Their structures were elucidated through comprehensive analysis of spectroscopic...
Fermented beet juice reinforces tight junctions and alleviates colitis via multi-pathway regulation [0.03%]
发酵的甜菜汁通过多通路调节强化紧密连接并缓解结肠炎
Yoon A Jeon,Premkumar Natraj,Young Jae Lee
Yoon A Jeon
This study investigated the anti-inflammatory and gut-protective effects of fermented beet mixed juice (BM), which contains betanin and levan-like polysaccharides. Chemical characterization of the water-soluble fraction (BM-WS) revealed a c...