Radicicol - A multifaceted natural product with promising anticancer and anti-inflammatory activities: Insights into its mechanisms and therapeutic perspectives [0.03%]
雷迪西 Colombier素：一种具有抗癌和抗炎前景的多功能天然产物：其机制和治疗潜力的见解
Hagar M Mohamed,Tasnim O Elsammani,Abdelsattar M Omar et al.
Hagar M Mohamed et al.
Radicicol (RAD) is a 14-membered resorcylic acid lactone biosynthesized mainly by fungi, originally known as an antifungal antibiotic and later as a potent Hsp90 (heat shock protein 90) inhibitor with diverse bioactivities. The current work...
Qifenggubiao granules attenuate LPS-induced inflammation through α7nAChR activation: An integrated study of network pharmacology and phytopharmacological validation [0.03%]
基于网络药理学和植物药理学验证的祛风护表颗粒通过激活α7nAChR缓解LPS诱导的炎症作用研究
Dong-Kai Tang,Yu-Hua Li,Yi Wang et al.
Dong-Kai Tang et al.
Qifenggubiao Granules (QFGBG) is a traditional Chinese medicine formula that has been reported to alleviate inflammatory diseases such as asthma, allergic rhinitis, Klebsiella pneumoniae, and chronic bronchitis. However, the underlying mech...
Stereoisomeric interactions of α- and β-pinene with essential oil compounds [0.03%]
α-和β-蒎烯与精油组分的立体异构相互作用
Nazihah Hoosen,Alvaro Viljoen,Sandy van Vuuren
Nazihah Hoosen
This study investigated the stereoselective antimicrobial, anti-quorum sensing, and toxicity profiles of the enantiomers of α- and β-pinene, individually and in 1:1 combinations with 14 essential oil compounds. Minimum inhibitory concentr...
Xi Zhang,Haidi Wu,Chen Wang et al.
Xi Zhang et al.
Dencichine, a precious medicinal material, also known as Tianqi acid, is a non-protein amino acid contained in Leguminous and Araliaceae plants. For years, the raw form of dencichine has been widely used in Chinese medicine for its hemostat...
The multifaceted properties of manna in skin wound healing include the enhancement of cell motility and differentiation, and antioxidant and anti-inflammatory actions [0.03%]
念珠糖促进皮肤伤口愈合的多效性作用包括增强细胞迁移和分化及抗氧化和抗炎作用
Raffaella Belvedere,Nunzia Novizio,Mariangela Palazzo et al.
Raffaella Belvedere et al.
Manna is a natural substance exuded from the trunk and branches of certain Fraxinus species, primarily from Fraxinus ornus L. and Fraxinus angustifolia Vahl. The manna here used was predominantly obtained from F. angustifolia. It has gained...
Nine undescribed C21-steroids with cytotoxic activity from the stems of Marsdenia tenacissima [0.03%]
杠柳糖参茎中的9个细胞毒活性C21甾体化合物
Wei-Bin Yuan,Tong-Xin Zheng,He-Hui Zhan et al.
Wei-Bin Yuan et al.
Chemical investigation on the acid hydrolysate of Marsdenia tenacissima stems resulted in the isolation of nine previously undescribed C21-steroids (1-9), along with six known analogues (10-15). The complete structures of these compounds we...
Dual inhibition of angiogenesis by Peucedanum praeruptorum Dunn root extract in endothelial and gefitinib-resistant lung cancer cells [0.03%]
蔊菜根提取物通过抑制内皮细胞及表皮生长因子受体突变肺癌细胞的血管生成而发挥抗肿瘤作用
Hyun-Ji Park,Shin-Hyung Park
Hyun-Ji Park
Peucedanum praeruptorum Dunn (PP) root, traditionally used in Korea to alleviate respiratory symptoms, has been reported to exhibit anticancer effects. In this study, we investigated the effects of an ethanolic extract of PP root (EPP) on t...
Arjunolic acid from Cyclocarya paliurus as a pleiotropic phytochemical effectively counteracts the "multiple parallel hits" in non-alcoholic fatty liver disease [0.03%]
苍术贝特素作为多种作用模式的植物化学物质有效对抗非酒精性脂肪肝病中的“多重并行损害”
Xian Zheng,Xiao-Gai Zhang,Jian Zhang et al.
Xian Zheng et al.
Arjunolic acid (AA), a bioactive triterpenoid isolated from Cyclocarya paliurus, could protect against NAFLD in our previous experiment. Based on the well-established "multiple parallel hits" hypothesis of NAFLD, we herein comprehensively a...
Curcumae Rhizoma and Sparganii Rhizoma component compatibility exerts an inhibitory effect on endometrial cancer by regulating HDAC8/PTEN/Akt axis [0.03%]
姜黄与芜荑药对通过调控HDAC8/PTEN/Akt信号轴抑制子宫内膜癌作用研究
Yuan Zhang,Fu Peng,Qinmei Zhou et al.
Yuan Zhang et al.
Sparganii Rhizoma (SR) and Curcumae Rhizoma (CR) are Chinese botanical medicines with potential anti-tumor properties yet to be fully characterized. This study aimed to clarify the influence of total flavonoids of SR (FSR), essential oil fr...
Novel norditerpene-phenanthrenes from Selaginella effusa inhibit T24 cell proliferation via blockade of the TRPV1/ STAT3/NF-κB pathwa [0.03%]
Selaginella effusa中新 Norditerpene-菲烷抑制T24细胞增殖通过阻断TRPV1 / STAT3 / NF-κB途径
Wen-Tao Sun,Li Luo,Cai-Wen Fan et al.
Wen-Tao Sun et al.
Ten novel norditerpene-phenanthrenes (1-10) and two new analogs (11-12) were isolated from Selaginella effusa. Their structures and absolute configuration were established by HRESIMS; IR, UV, 1D and 2D NMR spectroscopy; X-ray crystallograph...