Anti-inflammatory lathyrane diterpenoids from the aerial parts of Euphorbia wallichii [0.03%]
WALLICHII燕子木的抗炎倍半萜茋类化合物
Ren-Fen Ma,Xin-Cheng Zhuang,Qian Wu et al.
Ren-Fen Ma et al.
An intensive phytochemical study on the aerial parts of Euphorbia wallichii afforded ten lathyrane-type diterpenoids, including six formerly unreported ones (1-4, 6 and 8). Their structures were determined via comprehensive spectroscopic an...
Three undescribed Schinortriterpenoids from Schisandra chinensis and their neuroprotective effects [0.03%]
五味子中的三种新木脂内三萜及其神经保护作用
Yan-Li Zhang,Peng Jiang,Wu-Yan Chen et al.
Yan-Li Zhang et al.
Three undescribed SNTs, schisaterpene SU (1-3), were isolated from the extract of Schisandra chinensis. Their structures were elucidated on the basis of HR-ESI-MS, NMR data and ECD calculation. All compounds were evaluated for their Neuropr...
Experimental and computational approach to develop Rosmarinic acid against insulin resistance in the treatment of diabetes mellitus via PPAR-γ agonism [0.03%]
实验和计算开发鼠李糖酸通过PPAR-γ激动作用治疗糖尿病引起的胰岛素抵抗的方法
Haritha Harindranath,Aishwarya Susil,S Rajeshwari et al.
Haritha Harindranath et al.
From past to the present, plants and trees have benefited humans in many ways. As technology advanced the biological properties of plants are much more explored especially by the pharma industry. Rosemary plant has gained attention as a phy...
Four ambuic acid derivatives and one caryophyllene-type sesquiterpenoid from Pestalotiopsis chamaeropis [0.03%]
帕斯托利氏丝孢霉四例ambuic酸衍生物及一例蒈烯型倍半萜萃取物成分研究
Hao Zheng,Qing Ting Zeng,Liuxuan Yao et al.
Hao Zheng et al.
Fourteen specialized metabolites, including four previously undescribed ambuic acid derivatives (compounds 1-4) and an unreported caryophyllene-type sesquiterpenoid (compound 5), were isolated and characterized from the endophytic fungus Pe...
Protective effects of Yiqi Huoxue Huatan formula on atherosclerosis: An in vivo and in vitro study [0.03%]
益气活血化痰方对动脉粥样硬化保护作用的体内及体外研究
Lu Li,Yu Gao,Lei Liao et al.
Lu Li et al.
Atherosclerosis (AS) is a significant pathological contributor to cardiovascular disease, marked by high rates of death and illness globally. Yiqi Huoxue Huatan formula (YHH), a Chinese traditional decoction, has been clinically validated a...
An undescribed phytyl melilotic acid ester and chromomoric acid derivatives from Artemisia anomala and their cytotoxic and anti-inflammatory activities [0.03%]
一种未知的phytyl melilotic酸酯和chromomoric酸衍生物从Artemisia anomala及其细胞毒性和抗炎活性
Jie Meng,Lei Miao,Shuang Yao et al.
Jie Meng et al.
Phytochemical investigation of the ethanol extract from Artemisia anomala twigs and leaves led to the isolation and structural elucidation of four previously unreported compounds, including a phytyl melilotic acid ester designated as artema...
Jatrophane diterpenes from Euphorbia Sororia enhance chemotherapy drugs sensitivities in P-gp-induced multidrug resistance cells [0.03%]
埃uproboria sororia中的夹竹桃烷二萜类成分可通过上调P-糖蛋白逆转多药耐药性
Ayitila Maimaitijiang,Hequn Yang,Xiongwen Zhang et al.
Ayitila Maimaitijiang et al.
Investigating P-glycoprotein modulators with pharmacology effects and low toxicity to enhance P-gp-mediated chemotherapeutic drugs sensitivity against drug resistance cells is considered as one of the most feasible strategies to overcome mu...
Evaluating the therapeutic effect of Moutan cortex-Gardeniae Fructus-Coptidis Rhizoma on C57BL/6 mice with diabetic cardiomyopathy based on HPLC-network pharmacology and in vivo animal experiments [0.03%]
基于HPLC-网络药理学和体内动物实验评估丹皮栀子黄连治疗糖尿病心肌病Cxbl/6小鼠的疗效研究
Jincai Liu,Mengzhen Fan,Xu Yang et al.
Jincai Liu et al.
DCM is a serious complication of diabetes that eventually develops into heart failure and damages the health of human. Here, we study the therapeutic effect of MC-GF-CR on C57BL/6 mice with DCM. First, the aqueous extract powder of MC-GF-CR...
Revolutionizing pharmacological research of traditional Chinese medicine with single-cell omics technologies [0.03%]
单细胞组学技术推动中医药药效物质基础研究范式革新
Linya Wu,Qifang Wu,Xueting Du et al.
Linya Wu et al.
Traditional Chinese Medicine (TCM) offers a holistic approach to healthcare, yet its modernization is hindered by the immense complexity of its multi-component formulations and multi-target mechanisms. Conventional bulk-level analyses fail ...
Yanghuo Sanqi capsule against Alzheimer's disease by upregulating lipid metabolism: Network pharmacology and multi-omics analysis [0.03%]
网络药理学和多组学分析驱动的养获三七胶囊上调脂质代谢防治阿尔茨海默病作用机制研究
Jiali Rao,Haoxue Zheng,Min Lu et al.
Jiali Rao et al.
Yanghuo Sanqi capsule (YSC) consists of Yingyanghuo (Epimedium brevicornu Maxim., YYH) and Sanqi (Panax notoginseng (Burk.) F.H.Chen, SQ), which is used to treat cardiovascular diseases in Traditional Chinese Medicine (TCM). Additionally, t...