Indigenous medicine applications, phytochemical and pharmacological properties of Asteriscus graveolens: A comprehensive overview [0.03%]
Asteriscus graveolens的民族医药应用、植物化学和药理特性综述
Smail Amtaghri,Kopang Clemendi Mokhetho,Mitchel Otieno Okumu et al.
Smail Amtaghri et al.
Asteriscus graveolens (A. graveolens) belongs to the family Asteraceae. It is native to North Africa and the Asian deserts, with the majority of its distribution in Southwest Algeria and Southeast Morocco. It has historically been utilized ...
Prunella vulgaris polyphenols alleviate atherosclerosis by regulating lipid metabolism via suppressing STAT3 and activating the PI3K-Akt pathway [0.03%]
聚花过路黄多酚通过抑制STAT3和激活PI3K-Akt通路调节脂代谢从而缓解动脉粥样硬化
Taoli Sun,Wei Yuan,Xinru Li et al.
Taoli Sun et al.
Atherosclerosis (AS), a leading cause of cardiovascular diseases, remains a major challenge due to the lack of effective preventive and therapeutic strategies. This study investigated the anti-atherosclerotic effects and underlying mechanis...
Two new polyketides and a new γ-lactone-derived furanone from a soil fungus Trichoderma spirale BHM2-5 [0.03%]
由土壤真菌尖端孢链霉菌BHM2-5产生的两个新聚酮类和一个新γ-内酯衍生物色满酮类化合物
Joon Su Jang,Jae Sang Han,Yong Beom Cho et al.
Joon Su Jang et al.
Two previously undescribed polyketides, bukhansanketides A (1) and B (2), along with a γ-lactone-derived furanone, (S)-(-)-bukhansanfuranone (3), were isolated from Trichoderma spirale BHM2-5, together with four known compounds (4-7). Thei...
Limonin: Advances in extraction, synthesis, pharmacological mechanisms, and structural optimization for therapeutic potential [0.03%]
柠檬素：提取、合成、药理机制及结构优化研究进展
Xianghui Meng,Zhichao Xi,Xinwei Chen et al.
Xianghui Meng et al.
Limonin, a highly oxygenated nor-triterpenoid phytochemical abundant in Citrus plants, has attracted considerable attention because of its diverse pharmacological properties. Its significant anti-inflammatory, antioxidant, anticancer, antif...
Five new clerodane diterpenoids from Callicarpa integerrima and their anti-inflammatory activity [0.03%]
牻牛儿酮二萜类化合物穿心莲素Integrrimin A-E的抗炎活性研究
Muhammad Aurang Zeb,Jian-Lin Lai,Xing-Jie Zhang et al.
Muhammad Aurang Zeb et al.
Five previously undescribed clerodane diterpenoids named calintegerinoids A-E (1-5), featuring 5/6 and 6/6 fused ring systems, were isolated from Callicarpa integerrima. Their structures were determined using modern spectroscopic techniques...
HSQC-TOCSY fingerprinting-guided isolation of undescribed glycosides and scalemic pentaketides with neuroprotective activity from a mesophotic zone Ircinia sponge-associated fungus, Acremonium sp. NBUF233 [0.03%]
基于HSQC-TOCSY指纹图谱引导的从软珊瑚座腔菌中分离手性五元酮和不描述糖苷类神经保护活性代谢产物
Tingting Wei,Jinchang Li,Qianjing Zheng et al.
Tingting Wei et al.
HSQC-TOCSY fingerprinting-guided fractionation led to the discovery of three undescribed pentaketide, hexaketide, and monocyclofarnesol-type sesquiterpenoid glycosides, namely acremols A-C (1-3), along with new scalemic pentaketides (+)-4 a...
Design, synthesis, and anti-inflammatory activity studies of indanone derivatives containing cinnamic acid skeleton [0.03%]
含有桂皮酸骨架的茚酮衍生物的设计、合成及抗炎活性研究
Yu Zou,Yangyang Ren,Yuhui Liu et al.
Yu Zou et al.
Reactive oxygen species (ROS), as small-molecule signaling intermediates, are geynthesis and activity of aurone and indanone derivatinerated by immune and somatic cells in response to damage, infection, or stimulation. During the inflammato...
Mechanistic insights into Shengxian Sanren granules' effects on chronic heart failure: A synergistic study of UPLC-Q-TOF-MS/MS and network pharmacology [0.03%]
升仙三仁颗粒治疗慢性心力衰竭的机制探讨：UPLC-Q-TOF-MS/MS联用网络药理学的协同研究
Sisi Dai,Min Wang,Zheqin Zhu et al.
Sisi Dai et al.
Objective: This study aims to elucidate the pharmacological mechanisms and therapeutic targets of Shengxian Sanren Granules in the treatment of Chronic heart failure (CHF), with particular emphasis on the regulation of th...
New tetrahydrobenzocyclooctabenzofuranone and dibenzocyclooctadiene lignans from Kadsura jaonica [0.03%]
江西木通中二苯基环辛二烯和四氢苯并环辛并苯并呋喃酮型木质素类成分的研究
Yu Su,Jingjing Shen,Shuang Yao et al.
Yu Su et al.
Phytochemical investigation of Kadsura japonica led to the isolation and characterization of six new lignans, including four tetrahydrobenzocyclooctabenzofuranone ones designated as kadjaponins A - D (1-4), and two dibenzocyclooctadiene one...
Ethnobotanical and alkaloid composition with their cytotoxicity of Tabernaemontana polyneura: A review with in silico ADMET analysis [0.03%]
Tabernaemontana polyneura 的民族植物学和生物碱组成及其细胞毒性：结合计算 ADMET 分析的综述研究
Wen Xin Toh,Sin Yee Tang,Kae Shin Sim et al.
Wen Xin Toh et al.
Introduction: Tabernaemontana is a genus of plants traditionally used to treat various diseases, such as syphilis. Many cytotoxic indole alkaloids were isolated and characterized from plants of this genus, suggesting thei...