PI3K-inhibitory new anthraquinone-xanthone heterodimers from a deep-sea Epichloe sp. SCSIO 41042 [0.03%]
南海深海内生真菌Epichloe sp. SCSIO 41042的异戊二烯激酶抑制活性新蒽醌-黄酮杂二聚体化合物
Ying-Ying Song,Xiao-Yan Pang,De-Hua Yang et al.
Ying-Ying Song et al.
Two new xanthone-anthraquinone heterodimers (1 and 2), and eleven known anthraquinones (3-13) were isolated from the deep-sea derived Epichloe sp. SCSIO 41042 fermented on rice medium. Structurally, compounds 1-5 feature a unique bicyclo[3....
Discovery of new dammarane saponins from Actinostemma lobatum: C-3 monoglucosylation governs α-glucosidase inhibition [0.03%]
来源于乌蔹莓的达玛烷型皂苷及其对α-糖苷酶抑制作用的研究
Wei Li,Zhenlin Liu,Huiyu Li et al.
Wei Li et al.
Four new dammarane saponins, named actinostemmosides L-O (1-4), together with five known analogues (5-9), were isolated from the whole plant of Actinostemma lobatum. Their structures were established by HR-ESI-MS, exhaustive 1D/2D-NMR, and ...
Erratum to "Ethnobotanical and alkaloid composition with their cytotoxicity of Tabernaemontana polyneura: A review with in silico ADMET analysis" [Fitoterapia 186 (2025) 106851] [0.03%]
“Tabernaemontana polyneura的 ethnobotany和生物碱组成及其细胞毒性：结合in silico ADMET分析的综述”一文的勘误注释
Wen Xin Toh,Sin Yee Tang,Kae Shin Sim et al.
Wen Xin Toh et al.
Published Erratum
Fitoterapia. 2025 Sep 20:106869. DOI:10.1016/j.fitote.2025.106869 2025
Pharmacodynamic effects and mechanism of Pueraria lobata-Schisandra chinensis combination in the treatment of alcoholic liver disease [0.03%]
毛花豆根-五味子药动学效应及作用机制研究
Shihao Zhang,Ding Liu,Dongyan Guo et al.
Shihao Zhang et al.
With the increasing consumption of alcohol and alcoholic beverages, liver injury may occur. This has become an important cause endangering human health. As edible herbal medicines, Pueraria lobata (PL) and Schisandra chinensis (SC) are ofte...
Identification of a novel ACLY inhibitor proanthocyanidin B2 from grape seeds with lipid-lowering effect in vitro [0.03%]
从葡萄籽中鉴定出一种新型ACLY抑制剂原花青素B2及其体外降脂作用研究
Yao Wang,Pan Wang,Fangfang Xu et al.
Yao Wang et al.
ATP citrate lyase (ACLY) is a crucial enzyme in glycolipid metabolism. To date, only its one prodrug bempedoic acid has been approved. The discovery of direct ACLY inhibitors is important for developing new lipid-lowering drugs. Grape seeds...
Phenylpropanoid glycosides from the fruits of Lycium chinense and their potential anti-diabetic activity [0.03%]
枸杞果实茋类甘油苷及其潜在的降血糖活性
Yv-Xin Fan,Yu-Guo Ma,Yan-Jie Zhu et al.
Yv-Xin Fan et al.
Phytochemical study of the fruits of Lycium chinense Mill. allowed the identification of eight undescribed phenylpropanoid glycosides, namely lychinosides A-H (1-8), along with five known compounds (9-13). The structures of the new compound...
Bioactive 2-arylbenzofuran and chalcone derivatives from Morus mesozygia Stapf [0.03%]
Morus mesozygia Stapf中的生物活性2-芳基苯并呋喃和查耳酮衍生物
Jackson Obegi Matundura,Jackson T Mollel,Masum Miah et al.
Jackson Obegi Matundura et al.
The phytochemical investigation of the stem bark of Morus mesozygia afforded the fourteen known secondary metabolites moracin N (1), moracin S (2), mulberrofuran L (3), moracin C (4), moracin L (5), moracin M (6), moracin D (7), artopitheci...
A review of the traditional uses, chemical compounds, pharmacological effects and modern clinical applications of Dahuang Huanglian Xiexin Decoction [0.03%]
大黄黄连泻心汤的传统功效、化学成分、药理作用及现代临床应用研究进展综述
Ni Chen,Rui Tian,Yang Xiao et al.
Ni Chen et al.
Dahuang Huanglian Xiexin Decoction (DHXD) is a classic traditional Chinese medicine formula renowned for its effects in clearing heat, detoxifying, and promoting bowel movement. While traditionally used for syndromes characterized by abdomi...
Pharmacological landscape of linarin: From benchside mechanisms to potential bedside applications [0.03%]
LINARIN的药理景观：从实验机制到潜在临床应用
Mundher Kedhem,Farag M A Altalbawy,Lalji Baldaniya et al.
Mundher Kedhem et al.
Linarin, a glycosylated flavonoid derived from medicinal plants such as Buddleja and Chrysanthemum species, has emerged as a bioactive compound with significant pharmacological potential. This review provides a comprehensive overview of lin...
Endophytic fungus MH397503 mediates the structural modification of agarwood chromones and its anti-vascular endothelial injury activity [0.03%]
内生菌MH397503介导沉香茋类成分结构修饰及抗血管内皮细胞损伤活性研究
Jia-Min Cao,Li-Ping Zhu,Ya-Ting Lai et al.
Jia-Min Cao et al.
2-(2-phenylethyl)chromone (PEC) is one of the characteristic components of agarwood, and its derivatives (PECs) serve as the principal bioactive constituents, exhibiting diverse pharmacological properties. To mitigate the overexploitation o...