ALS-related proteinopathies: From TDP-43 to mitochondrial proteinopathies [0.03%]
从TDP-43到线粒体蛋白病的肌萎缩侧索硬化症相关蛋白病
Emmanuelle C Genin,Véronique Paquis-Flucklinger
Emmanuelle C Genin
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the progressive loss of motor neurons. ALS often overlaps clinically and pathologically with frontotemporal dementia (FTD), the second most common fo...
The challenges of experimental pharmacology in identifying novel treatments for Parkinson's disease [0.03%]
实验药理学在寻找新型帕金森病治疗药物方面所面临的挑战
Margaux Teil,Philippe Huot
Margaux Teil
An important part of the field of experimental pharmacology encompasses the study of the effects of molecules in animals. In the case of Parkinson's disease (PD), animal models have played an invaluable role in refining our understanding of...
Bryon Silva,Mael Lemoine,Michael Rera et al.
Bryon Silva et al.
The gastrointestinal (GI) tract is innervated by intrinsic neurites and extrinsic pathways linking it bidirectionally to the central nervous system. These circuits regulate digestion, metabolism, and homeostasis across metazoans. Comparativ...
Sexually dimorphic neural circuits underlying mating behaviors: Insights from worms, flies, and mice [0.03%]
性别二态神经环路调控交配行为——线虫、果蝇和小鼠中的研究进展
Xia-Jing Tong,Fei Wang,Xiaohong Xu
Xia-Jing Tong
In sexually reproducing animals, males and females are biologically specialized to produce sperm or eggs, which must unite through mating to ensure successful reproduction. To facilitate this, each sex displays sex-specific, often stereotyp...
Nolwenn Adam,Jessica Tollkuhn
Nolwenn Adam
Social behaviors are crucial for reproductive success and survival. In vertebrates, these behaviors are sexually dimorphic due to distinct hormonal environments in development and adulthood. The underlying neural pathways, collectively know...
Ivette M Sandoval,Michael F Salvatore,Fredric P Manfredsson
Ivette M Sandoval
The prospect of successful use of gene therapy to treat neurological disorders, including Parkinson's disease (PD), can be increased by understanding the molecular etiology underlying disease symptoms and neurodegeneration. The major hurdle...
Corrigendum to "New insights into axonal regulators of dopamine transmission in health and disease" [Curr Op Neurobiol 94 (2025) 103093] [0.03%]
关于“健康与疾病状态下多巴胺传递的新见解”的勘误[当前神经生物学意见第94卷(2025年)103093号论文]
Kathryn L Todd,Kaitlyn M L Cramb,Katherine R Brimblecombe et al.
Kathryn L Todd et al.
Published Erratum
Current opinion in neurobiology. 2025 Dec 18:96:103147. DOI:10.1016/j.conb.2025.103147 2025
Yulong Li,Peter Scheiffele
Yulong Li
Context matters: Conflicting roles of interferon-γ signaling in CNS diseases [0.03%]
背景很重要：干扰素-γ信号在中枢神经系统疾病中扮演着相互矛盾的角色
Jonathan Nulman,Jason D Ulrich,David M Holtzman
Jonathan Nulman
Interferon-gamma (IFNγ) is a pleiotropic cytokine produced by CD8+ and CD4+ Th1 T cells, natural killer cells, natural killer-T cells, and type 1 innate lymphoid cells. Canonical IFNγ-induced genes include cytokines, chemokines, antigen p...
Bridging the gap between physics and biology of hearing: Timing and amplification [0.03%]
听觉的物理和生物研究之间的桥梁： timing 和 amplification
Christine Petit,Paul Avan
Christine Petit
In mammals, the exquisite sensitivity and frequency selectivity of sound analysis rests on properly timed cycle-by-cycle feedback that compensates for friction and tunes the mechanical resonances of the auditory sensory organ. This feedback...