Ethanol exposure suppresses Microglia pro-inflammatory response induced by SARS-CoV2-Spike protein [0.03%]
乙醇暴露抑制SARS-CoV-2刺突蛋白诱导的小胶质细胞促炎反应
Beatriz Esteves,Letícia Angelica Henrique do Nascimento,Joice Stipursky
Beatriz Esteves
In the central nervous system (CNS), microglial cells regulate the immune response by mediating neuroinflammation. Alcohol abuse leads to neuroinflammation and neurodegeneration in CNS. In the context of COVID-19, neuroinflammation and glia...
The impact of drinking patterns on the relationship between alcohol use and levels of serum High-Density Lipoprotein Cholesterol (HDL-C) [0.03%]
饮酒方式对酒精使用与血清高密度脂蛋白胆固醇水平关系的影响
Jørgen G Bramness,Jørg Mørland,Torgeir Gilje Lid et al.
Jørgen G Bramness et al.
Alcohol intake is known to influence serum high-density lipoprotein cholesterol (HDL-C), yet how drinking patterns shape this association is less researched. We examined whether frequency of drinking versus amount per occasion was different...
Effects of short-term abstinence on alcohol elimination rate: Sex differences and method comparisons using the intravenous alcohol clamp [0.03%]
短期戒酒对酒精消除速率的影响：性别差异及静脉酒精钳法的比较研究
Jumar Etkins,Sean J O&#x;Connor,Wei Wu et al.
Jumar Etkins et al.
Background: Sex differences in the escalation of drinking after brief abstinence have been documented. The possibility that changes in alcohol metabolism may explain these differences has not been previously examined. We ...
Circadian clock genes Bmal1 and Per2 in the nucleus accumbens are negative regulators of alcohol-drinking behavior in mice [0.03%]
核(acc)中的昼夜钟基因Bmal1和Per2可抑制小鼠的酒精饮用行为
Juliana Herrera,Margo Button,Pascale Doherty-Haigh et al.
Juliana Herrera et al.
Alcohol use disorder (AUD) is a leading cause of morbidity and mortality worldwide, characterized by cycles of heightened craving and excessive, uncontrolled consumption of alcohol despite progressive decline in physical and mental health. ...
Regulation of amygdala and dopamine system in naïve and chronic alcohol states [0.03%]
naive和慢性酒精状态下的杏仁核和多巴胺系统的调节
Michel Mizuki Kameda-Henry,Colby M Kinser,Christopher Lapish et al.
Michel Mizuki Kameda-Henry et al.
Chronic alcohol use disorder (AUD) is associated with a transition from reward-driven to negative affect-driven alcohol seeking. However, the circuit-level mechanisms linking motivational, affective, and stress systems remain unclear. We de...
The Effects of Developmental Ethanol Exposure & Postnatal Choline Supplementation on Long-Term Choline Metabolism [0.03%]
孕期乙醇暴露及产后胆碱补充对长期胆碱代谢的影响
Jessica A Baker,Karen J Thomas,Teodoro Bottiglieri et al.
Jessica A Baker et al.
Prenatal alcohol exposure (PAE) can disrupt development, leading to alterations in physical, health, and behavioral outcomes, referred to as fetal alcohol spectrum disorders (FASD). Although alcohol likely impacts fetal development through ...
Early ethanol exposure during gestation and lactation disrupts gut integrity and enhances ethanol intake in C57BL/6 mice offspring [0.03%]
妊娠期和哺乳期早期接触乙醇会破坏后代小鼠肠道完整性并增加其对乙醇的摄入量
A Wille-Bille,P Peñalver Abed,C Ravasi et al.
A Wille-Bille et al.
Prenatal alcohol (ethanol) exposure (PAE) produces enduring neurobehavioral alterations, but the contribution of gut integrity to this vulnerability remains unclear. This study examined if moderate-intermittent PAE, induced via voluntary et...
Effects of acute alcohol on pain-related activity of the anterior and posterior insular cortices [0.03%]
急性酒精对脑岛前部和后部疼痛活动的影响
Adriana K Cushnie,Landrew S Sevel,Nicholas J Bush et al.
Adriana K Cushnie et al.
Background: Self-medicating pain with alcohol is common. Chronic heavy alcohol use is associated with increased risk for chronic pain and alcohol-related consequences. The anterior (AIC) and posterior (PIC) insula play ke...
Adolescent ethanol exposure produces sex-dependent modulation of ethanol-induced analgesia and cell type-specific vlPAG activation [0.03%]
青春期接触酒精会引发性别特异的酒精镇痛作用调节以及腹侧延髓导血管区细胞类型特异的活化反应
Lucas Albrechet-Souza,Patrick J Logarbo,Hla Y Min et al.
Lucas Albrechet-Souza et al.
Alcohol is commonly reported to produce analgesic effects, yet the mechanisms underlying alcohol-induced analgesia and the long-term impact of adolescent alcohol exposure on pain processing remain poorly understood. The present study examin...
Impact of impaired endogenous neurosteroidogenesis on outcomes following chronic alcohol exposure [0.03%]
内源性神经类固醇生物合成障碍对慢性酒精暴露后预后的影响
Katrina Blandino,Yingchu He,Lifen Htet et al.
Katrina Blandino et al.
Alcohol use disorder is a major public health concern worldwide and there is a high comorbidity with psychiatric disorders. The basolateral amygdala (BLA) has been implicated in both mood and alcohol use disorders; however, the mechanisms c...