Development and validation of a machine learning model for frailty screening using claims data in Japan: the Longevity Improvement & Fair Evidence Study [0.03%]
日本利用理赔数据进行脆弱性筛查的机器学习模型的开发与验证：长寿改善及公平证据研究
Kengo Kawaguchi,Megumi Maeda,Futoshi Oda et al.
Kengo Kawaguchi et al.
Background: Frailty is an ageing-associated multidimensional condition linked to higher long-term care (LTC) needs, healthcare expenditures, and mortality. In Japan, the Questionnaire for Medical Checkup of Old-Old (QMCOO...
Age-related diversity of the oral and gut microbiome and its correlation with systemic fatty acids and cytokine profiles in healthy subjects [0.03%]
健康受试者中年龄相关的口腔和肠道菌群多样性及其与系统性脂肪酸和细胞因子谱的相关性研究
Itzel Ivonn López-Tenorio,Luis Alejandro Constantino-Jonapa,Samuel Jaimez-Alvarado et al.
Itzel Ivonn López-Tenorio et al.
Background and aim: Advances in human microbiome research have highlighted its influence on host health. This study aimed to characterize the oral microbiome (OM) and gut microbiome (GM) and to examine their relationships...
Association of accelerometer-measured rest-activity rhythm patterns and parameters with cardiovascular and all-cause mortality in older adults: Population-based cohort study [0.03%]
基于人群的队列研究：老年人心血管疾病和全因死亡率与加速仪测量的休息-活动节律模式和参数的相关性
Shuaijie Chen,Qiong Su,Ruming Shen et al.
Shuaijie Chen et al.
Background: Rest-activity rhythm (RAR) is a fundamental biomarker of age-related circadian system deterioration. However, the long-term effect of RAR patterns on mortality in older adults remains unclear. ...
Comprehensive evaluation of appendicular lean mass and sarcopenia on human health: evidence from the NHANES program [0.03%]
人体四肢瘦体重和少肌症的全面评估：来自NHANES项目的证据
Xiao Long,Ruizhi Chen,Yanmin Lu et al.
Xiao Long et al.
Background: While accumulating points have been figured out the importance of muscle function, less clinical or epidemiological evidence have been provided. This study aimed to provide new evidence on the systemic effects...
Age and mating status modulate combined efficacy of α-lipoic acid and climbing to mitigate high-fat diet-induced oxidative stress in Drosophila melanogaster [0.03%]
年龄和交配状况调节α-生育酚和攀爬作用的联合效应以缓解果蝇(Drosophila melanogaster)高脂饮食诱导的氧化应激
Madappa Machamada Bheemaiah,Debarati Chattopadhyay
Madappa Machamada Bheemaiah
High-fat diet (HFD) intake is a potent inducer of oxidative stress, promoting metabolic dysfunction and accelerated ageing. Identifying interventions capable of mitigating this persistent redox burden is therefore essential. This study inve...
Association between weight-adjusted waist index (WWI) and multimorbidity: Evidence from NHANES and prospective validation in CHARLS [0.03%]
基于体重的腰围指数(WWI)与多发病的关系：来自NHANES的证据以及在CHARLS中进行的前瞻性验证
Xiao-Rong Ye,Ding-Qi Shi,Rui-Xuan Li et al.
Xiao-Rong Ye et al.
Background: The burden of chronic diseases is known to be significantly increased by obesity, yet conventional measures like waist circumference (WC) and body mass index (BMI) do not accurately capture central adiposity. ...
Remnant cholesterol associated with all-cause mortality in oldest-old acute coronary syndrome patients: A cohort study [0.03%]
余胆固醇与急性冠状动脉综合征老年人全因死亡率的关系：一项队列研究
Zijie Dang,Boning Zhou,Yongkang Su et al.
Zijie Dang et al.
Background: Previous studies showed that remnant cholesterol(RC) partially explained the residual risk of cardiovascular disease. We tried to test the hypothesis that remnant cholesterol is a risk factor for all-cause mor...
The effects of extracellular matrix degradation mediated by chronic inflammation in aged skin on the structure and function of eccrine sweat glands [0.03%]
慢性炎症介导的皮肤老化过程中基质降解对汗腺结构和功能的影响
Xiaohan Liu,Guihong Yang,Yuanli Ye et al.
Xiaohan Liu et al.
Eccrine sweat glands (ESGs) are critical organs for human thermoregulation, yet their function progressively declines with aging. This study aims to investigate the underlying mechanisms responsible for the age-related impairment of ESG fun...
Muscle-brain axis mechanisms linking community-based exercise to cognitive function in older adults: A five-arm randomized controlled trial [0.03%]
基于社区的运动通过肌脑轴机制改善老年人认知功能的真实世界随机对照研究
Jiadong Qiu,Xiongying Song,Jian Wang et al.
Jiadong Qiu et al.
Objective: To compare community-feasible exercise effects on cognition and explore muscle-brain axis mechanisms in older adults. Methods: ...
Higher openness and conscientiousness are associated with lower risk of long-term care needs: A 22-year follow-up of community-dwelling older adults in Japan [0.03%]
较高开放性和尽责性与日本社区老年人长期照护需求较低的风险有关：22年随访研究
Yukiko Nishita,Chikako Tange,Sayaka Kubota et al.
Yukiko Nishita et al.
Background: Personality traits have been associated with physical and mental health outcomes, yet their relationship with long-term care (LTC) needs remains understudied. ...