Single-cell expression quantitative trait loci-based Mendelian randomization identifies MAN1A2 in naive CD4+ T cells as a candidate therapeutic target for osteoarthritis [0.03%]
基于单细胞表达定量性状位点的孟德尔随机化识别出naive CD4+ T细胞中MAN1A2为骨关节炎潜在治疗靶点
Xuan-Yi Zhou,Fang-Yu Liu,Yan Zhang et al.
Xuan-Yi Zhou et al.
Background: Osteoarthritis (OA) is a leading cause of chronic pain and disability worldwide, with growing evidence implicating immune dysregulation in its pathogenesis. However, the specific peripheral immune cell populat...
Myokines as molecular mediators of the muscle-brain axis: Mechanisms linking sarcopenia to cognitive decline and implications for preventive strategies in ageing - A narrative review [0.03%]
肌肽作为肌肉-大脑轴线分子介体：连接肌肉减少和认知衰退的机制及其在衰老预防策略中的意义-综述文章
Dhika Dharmansyah,Laili Rahayuwati,Irma Ruslina Defi et al.
Dhika Dharmansyah et al.
Sarcopenia and cognitive decline frequently co-occur in older adults, and growing evidence indicates that these conditions share a common biological substrate centred on the muscle-brain axis. In this narrative review we synthesise contempo...
Serum 25(OH) vitamin D and SIRT1- VDR- miR-124 expression: A controlled interventional study in a vitamin D-deficient male rat model [0.03%]
维生素D缺乏大鼠模型中血清25(OH)维生素D与SIRT1-VDR-miR-124表达的相关性研究
Poulami Dhar,Shailaja Moodithaya,Prajna Bhandary et al.
Poulami Dhar et al.
Background: Epigenetic aging is a new dimensional advancement in geroscience that continually addresses factors beyond genetic determinants of longevity. It occurs through three conventional pathways, one of which is non-...
A self-determination theory-based cognitive prosthetic to improve medication adherence in African American older adults with diabetes [0.03%]
基于自我决定理论的认知假肢改善糖尿病非洲裔美国老年人的药物依从性
William Bayer,Anthony A Sterns
William Bayer
Background and objectives: Medication nonadherence among older adults with type 2 diabetes is common and contributes to preventable complications, especially in African American communities. MediTeddi is a new cognitive p...
SIRT3 inhibition promotes age-associated vascular impairment by mediating mitochondrial dysfunction and endothelial-to-mesenchymal transition [0.03%]
通过介导线粒体功能障碍和内皮细胞向间充质细胞转化促进血管衰老的SIRT3抑制作用
Shiye Ke,Huijun Yang,Weifeng Lu et al.
Shiye Ke et al.
Background: Vascular aging profoundly impacts on cardiovascular disease. Sirtuin 3 (SIRT3) is a key regulator of metabolic homeostasis whose expression declines with age; however, the mechanisms linking SIRT3 deficiency t...
Action simulation as an intervention to improve balance, mobility and gait in healthy older adults: A scoping review [0.03%]
动作模拟作为改善健康老年人平衡、移动性和步态的干预措施：一项综述研究
Neza Grilc,Adam Cocks,Elmar Kal et al.
Neza Grilc et al.
Falls in older adults are a significant public health concern. Action simulation interventions involving action observation and/or motor imagery have been proposed as alternative or adjunct strategies to physical exercise for reducing fall ...
Senomorphic agents: Multi-target strategies to tame the senescence-associated secretory phenotype for healthy ageing [0.03%]
Senomorphic制剂：针对衰老相关分泌表型的多靶点策略以实现健康老龄化
Yue Kong,Qiuyan Zhang,Jianzhong Zhang et al.
Yue Kong et al.
Cellular senescence is a central driver of organismal ageing and related pathologies, primarily promoting chronic inflammation and tissue dysfunction through the senescence-associated secretory phenotype (SASP). Unlike senolytics, which aim...
Muscle mechanical and architectural adaptations in response to different endurance training modalities in older adults [0.03%]
不同耐力训练模式下老年人肌肉机械和结构的适应性变化
Michele Trinchi,Samuel D&#x;Emanuele,Andrea Monte et al.
Michele Trinchi et al.
Introduction: This study examined the effects of various cycling endurance training modalities, matched for total workload, on muscle mechanical and architectural characteristics in older adults. ...
Effects of free-weight resistance training based on hexagonal barbell deadlift in older women: A 24-week randomized controlled trial [0.03%]
基于六角杠铃硬拉的自由重量阻力训练对老年女性的影响：一项为期24周的随机对照试验
Juezhen Zhang,Yung Cheng Huang,Yi-Hung Liao et al.
Juezhen Zhang et al.
Purpose: This randomized controlled trial examined effects of a 24-week hexagonal barbell deadlift (HBDL)-based free-weight resistance training program on body composition, trunk muscle function, and functional performanc...
Exercise modality differentially modulates cognitive function, emotional behavior, and muscle-brain signaling in an aluminum-induced neurodegeneration rat model [0.03%]
运动方式通过不同方式调节铝诱导的大鼠神经退行性模型中的认知功能、情感行为和肌肉-大脑信号转导
Muhammad Hafiz Zuhdi Fairof,Amirul Hafiz Ahmad Abdullah,Nur Aisyah Anuar et al.
Muhammad Hafiz Zuhdi Fairof et al.
Neurodegenerative disorders are characterized by progressive cognitive decline and neuronal dysfunction driven by oxidative stress, neuroinflammation, and metabolic dysregulation. Exercise is a promising non-pharmacological strategy to miti...