The association between cystatin C and hip fracture risk: A longitudinal cohort study of China Health and Retirement Longitudinal Study (CHARLS) [0.03%]
基底膜素C与中国老年人髋部骨折风险关联的前瞻性队列研究：基于中国健康与养老追踪调查数据的分析
Youzhi Lian,Yuyun Wu,Guowen Li et al.
Youzhi Lian et al.
Purpose: Cystatin C, a cysteine protease inhibitor linked to kidney function, cardiovascular disease, and osteoporosis, has unclear associations with hip fracture risk. This study examines this relationship using longitud...
Therapeutic potential of Cistanche against Parkinson's disease via regulating circulating inflammation: Insights from Mendelian randomization, molecular docking, and in vivo studies [0.03%]
肉苁蓉通过调节循环炎症治疗帕金森病的潜力：来自孟德尔随机化、分子对接和体内研究的见解
Haixin Liu,Yue Chen,Chenyue Li et al.
Haixin Liu et al.
Background: Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide, and no curative treatment is currently available. Although inflammation has been increasingly implicated in PD, the caus...
Exploring estrogen synthesis and metabolism related markers and immune dynamics in osteoporosis-insights from single-cell RNA sequencing and Mendelian randomization [0.03%]
从单细胞RNA测序和孟德尔随机化洞察中探索骨质疏松症相关的雌激素合成及代谢标志物与免疫动态特征
Xiaoyun Hao,Gang Sun,Yu Wang et al.
Xiaoyun Hao et al.
Background: Osteoporosis (OP) is characterized by decreased bone mineral density and an increased fracture risk, often due to declining sex hormone levels that weaken bone strength. This study aims to explore estrogen rel...
Harmonization of late-life participation in cognitively stimulating activities across four cohort studies of cognitive aging [0.03%]
四项认知衰老队列研究中老年人参与认知刺激活动的协调性分析
A R Zammit,A L Gross,L Yu et al.
A R Zammit et al.
Objective: We harmonized self-reported survey data measuring late-life participation in cognitively stimulating activities across four cohort studies of cognitive aging. ...
Epigenetic and hormonal effects of supervised combined aerobic and weight-bearing on bone health in postmenopausal women [0.03%]
绝经后女性在监督下的有氧和负重运动对骨骼健康的表观遗传学和激素作用的影响
Hongshi Han,Haijuan Liu,Xian Li et al.
Hongshi Han et al.
Background: Exercise training is increasingly recognized as a complementary therapy to support skeletal health in postmenopausal women. However, its epigenetic influence on circulating bone-related microRNAs and its hormo...
Systems-level modelling of DNA damage, senescence, and stem cell dynamics in ageing [0.03%]
DNA损伤、衰老和干细胞动态的老化系统模型
Anchen Che,Amy E Morgan,Mark T Mc Auley
Anchen Che
Ageing entails a variety of cellular and physiological changes that increase susceptibility to disease and death. A significant contributor to ageing is cellular senescence, a state of irreversible cell cycle arrest triggered by stressors s...
A dual-pathway model of depression's mediation between chronic pain and dementia [0.03%]
慢性疼痛与痴呆之间抑郁的中介作用双路径模型
Ying Tan,Shiyu Chen,Qi Tian et al.
Ying Tan et al.
Background: Although chronic pain is a recognized risk factor for cognitive decline and dementia, often mediated by depression, it remains unclear whether depression plays a differential mediating role across chronic pain...
Association between dietary carbohydrate-to-fiber ratio and sleep duration among American adults with constipation: A cross-sectional study [0.03%]
膳食碳水化合物/纤维比与美国成人便秘相关睡眠时长之间的关系：一项横断面研究
Jiali Zhang,Changyu Yao,Ya Zheng et al.
Jiali Zhang et al.
Background: The carbohydrate-to-fiber ratio is a novel indicator for evaluating dietary carbohydrate quality that can more accurately reflect an individual's dietary quality, but its association with sleep duration in the...
Hypertension is associated with knee osteoarthritis pain in an age-dependent manner [0.03%]
高血压以年龄依赖性的方式与膝骨关节炎疼痛相关联
Carlos J Cruz,Javier A Tamargo,Muhammad Abbas et al.
Carlos J Cruz et al.
Objective: Osteoarthritis (OA) is a painful and prevalent disease among older adults. Hypertension, commonly comorbid with OA and associated with aging, may influence OA pathology and pain. We hypothesized that hypertensi...
Integrated metabolomics and machine learning identify potential biomarkers and metabolism-related targets for MASLD in older adults [0.03%]
整合代谢组学和机器学习识别老年人MASLD潜在生物标志物和代谢相关靶点
Ze Jin,Mengpei Zhu,Ziwen Wang et al.
Ze Jin et al.
Background: Given the high prevalence and serious health threats of Metabolic dysfunction-associated steatotic liver disease (MASLD) in older people, uncovering the pathological features of MASLD in the context of age is ...