Genetic associations and mediating effects of insulin resistance between hypertension and sarcopenia: A bidirectional two-sample Mendelian randomization study [0.03%]
高血压和肌少症之间胰岛素抵抗的遗传关联及中介作用：双向两样本孟德尔随机化研究
Jingfeng Zou,Liyin Zhang,Shaotian Li et al.
Jingfeng Zou et al.
Objective: Hypertension and sarcopenia are major global public health problems among the aging society. This study aims to explore the causal associations and mediating effects of insulin resistance (IR) between hypertens...
Resistance training for the prevention and management of sarcopenia in older adults: Mechanisms, efficacy, and future applications [0.03%]
抗阻运动在老年人 sarcopenia 的预防和管理中的作用：机制、疗效及未来应用
Lu Lan,Liu Caini,Wei Wei
Lu Lan
Sarcopenia is a major health concern in aging populations. Resistance training (RT) is widely recommended to improve muscle mass, strength, and physical function in older adults. In recent years, research on both biological mechanisms and c...
Effects of body composition on age- and sex-related differences in resting metabolic rate from a healthy aging cohort [0.03%]
一项健康老龄化队列研究中体质组成对静息代谢率年龄和性别差异的影响
Marcos Moliné,Stephanie R Heimler,Nikki Bergstrom et al.
Marcos Moliné et al.
Resting metabolic rate (RMR) accounts for the majority of the total energy expenditure. While RMR is known to decline with advancing age and is recognized to be lower in females compared to males, the mechanisms underlying these differences...
Effect of statin use on the development of sarcopenia in older adults: A systematic review and meta-analysis [0.03%]
他汀类药物使用对老年人 sarcopenia 发病的影响：系统回顾和荟萃分析
María Dolores Mondéjar-Barrios,Jhair Alexander Leon-Rodriguez,Karem Justhin Rodas-Trujillo et al.
María Dolores Mondéjar-Barrios et al.
Background: Given the ongoing debate regarding whether statin therapy contributes to muscle decline in older adults, this study aims to synthesize the available observational evidence on the association between statin use...
Effect of bedrest on the human gut and oral microbiome: implications for frailty [0.03%]
卧床休息对人体肠道和口腔微生物组的影响：对衰弱的启示
Monica Alvaro-Fuss,Vanessa DeClercq,Joanna M Blodgett et al.
Monica Alvaro-Fuss et al.
The physiological effects of spaceflight resemble those of ageing and prolonged inactivity, and ground-based microgravity analogs have emerged as promising models for studying frailty. The human microbiome is increasingly recognised for its...
Magnetic resonance spectroscopy as a non-invasive tool for assessing brain and muscle adaptation to exercise training in older age: a scoping review into existing research [0.03%]
磁共振光谱作为非侵入性工具评估老年人脑和肌肉对运动训练的适应：现有研究综述框架审查
Oron Levin,Ivica Just,Radka Klepochova et al.
Oron Levin et al.
Background: Exercise training has attracted increasing attention as a non-pharmacological intervention approach to counteract age-related deterioration of brain and muscle function, yet objective biomarkers are needed to ...
Construction of a risk prediction model for oral frailty in hospitalized elderly patients with chronic diseases [0.03%]
慢性病住院老年患者口腔衰弱风险预测模型的构建
Yuxuan Huang,Wenxuan Du,Yang Yang et al.
Yuxuan Huang et al.
Background: Oral frailty is closely associated with systemic health and quality of life in elderly patients, particularly those with chronic diseases. Early identification of high-risk groups and targeted prevention are e...
Bidirectional causal associations between immune cell phenotypes and age-related macular degeneration subtypes: A mendelian randomization study [0.03%]
免疫细胞表型和年龄相关性黄斑变性亚型之间的双向因果关联：一项孟德尔随机化研究
Zihao Zhuang,Xinyu Jia,Haixia Lin et al.
Zihao Zhuang et al.
Background: Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the elderly population, characterized by two primary subtypes: dry AMD (dAMD) and wet AMD (wAMD). While immune mechanism...
Epidemiological trends, risk factor contributions, and future projections of cardiovascular disease among Chinese adults ≥45 years: insights from GBD 2021 and CHARLS [0.03%]
基于GBD 2021和CHARLS的中国≥45岁成人心血管病流行趋势、危险因素贡献及未来预测
Junyan Wu,Yuegui Wang,Shiqi Li et al.
Junyan Wu et al.
Objective: This study assessed epidemiological trends from 1990 to 2021, quantified risk factors contributions to CVD burden, and predicted risk-attributable mortality. ...
Characterization of EEG power spectrum correlates of standing and walking in older adults: A scoping review [0.03%]
老年人站立和行走的EEG功率谱相关性特征：综述研究
Melike Kahya,Yiting Li,Junhong Zhou et al.
Melike Kahya et al.
Aim: Growing evidence suggests that age-related declines in balance and gait are major contributors to falls, loss of independence, and reduced quality of life in older adults, yet the underlying neural mechanisms remain ...