The interplay between the immune microenvironment and bone aging: From molecular mechanisms to therapeutic interventions [0.03%]
免疫微环境与骨衰老的相互作用：从分子机制到治疗干预
Jianxu Wang,Yijun Xin,Zihao Dong et al.
Jianxu Wang et al.
The core mechanism of skeletal aging lies in the comprehensive disruption of microenvironmental homeostasis, involving a multidimensional interactive network comprising immune cells, mesenchymal stem cells, and their differentiated lineages...
Mechanism by which 24-week different-volume high-intensity interval training ameliorates renal fibrosis in naturally aging rats via regulating the TGF-β1/Smad pathway [0.03%]
不同体积24周高强度间歇训练改善自然衰老大鼠肾纤维化的机制研究：通过调节TGF-β1/Smads信号通路
Jiabao Zhang,Kaiyin Cui,Huiting Wei et al.
Jiabao Zhang et al.
Objective: To investigate the effects of 24-week different-volume high-intensity interval training (HIIT) on renal fibrosis in naturally aging rats and to elucidate the underlying mechanisms based on the TGF-β1/Smad sign...
Habitual bent leg sitting and lying times are associated with worse frailty, mobility and balance in long-term care residents [0.03%]
长期护理机构中反复弯腿坐立和躺卧与居民虚弱、移动能力和平衡能力下降有关
Madeline E Shivgulam,Emily E MacDonald,Jocelyn Waghorn et al.
Madeline E Shivgulam et al.
The impact of habitual postures on frailty, and balance, mobility, and transfer ability, particularly among people in long-term care. We sought to characterize the time spent in detailed postures and the relationships they have with frailty...
Associations between sleep duration trajectories and sarcopenia among middle-aged and older Chinese adults [0.03%]
中老年中国人睡眠时间轨迹与肌少症的关联研究
Wanli Deng,Changqing Li,Xiaojiang Zhao
Wanli Deng
Background: The association between a single time-point measurement of sleep duration and sarcopenia has been extensively explored in existing literature. However, the potential link between sleep duration trajectories an...
Preserving intrinsic capacity in midlife women: A mixed-methods study of a personalized multicomponent intervention aligned with the WHO ICOPE framework [0.03%]
结合WHOICOPE框架的个性化多模式干预在中年女性中的定性定量混合研究
Ruby Yu,Cecilia Tong,Matthew Yu et al.
Ruby Yu et al.
Background: Intrinsic capacity (IC) preservation during midlife represents a critical yet underutilized opportunity for preventing age-related functional decline. We developed ANONYMOUS, a 12-week personalized multicompon...
Disruption of Rab9-dependent mitophagy contributes to menopause-induced sarcopenia [0.03%]
Rab9依赖的线粒体自噬紊乱促成了绝经引起的肌少症
Shota Uebo,Yoshiyuki Ikeda,Yoshihiro Uchikado et al.
Shota Uebo et al.
Aim Sarcopenia, a major cause of frailty in postmenopausal women, is linked to mitochondrial dysfunction, but the underlying mechanisms remain unclear. This study aimed to clarify whether mitophagy, a mitochondrial quality control mechanism...
Association between serum uric acid and frailty: Evidence from NHANES database and perioperative geriatric frailty cohort [0.03%]
血尿酸与衰弱的关系：来自NHANES数据库和术前术后老年衰弱队列的证据
Jirun Wang,Yaqi Han,Yan Xin et al.
Jirun Wang et al.
Background: Frailty is a common syndrome among older adults, increasing vulnerability to adverse outcomes. Serum uric acid (SUA) has been associated with several aging-related diseases, but its relationship with frailty r...
Neurodegeneration and glial activation related blood biomarkers in Alzheimer's disease: A systematic review and an updated meta- analysis [0.03%]
阿尔茨海默病相关神经退行性变和胶质活化的血液生物标志物的系统评价和更新型meta分析
Rasoul Ebrahimi,Amir Abbas Salehi Amniyeh Khozani,Mohammad Mahdi Masouri et al.
Rasoul Ebrahimi et al.
Background and objectives: This systematic review and meta-analysis aims to evaluate blood biomarkers associated with neurodegeneration and glial activation, specifically GFAP, NfL, YKL-40, MCP-1, neurogranin, GAP-43, S10...
Dehydroepiandrosterone opposes cardiac aging via NFκB/IL-10/Sirt1/Nrf2 mediated pathway in aged rats [0.03%]
脱氢表雄酮通过NFκB/IL-10/Sirt1/Nrf2信号途径对抗大鼠心脏衰老
Yahya M Naguib,Mohamed S Rizk,Reda A Abo-Elsoud
Yahya M Naguib
Background: Cardiovascular aging is characterized by structural and functional deterioration of the heart, mediated by chronic inflammation, oxidative stress, and impaired cellular defense pathways. Dehydroepiandrosterone...
Life after migration: A comparative study on successful aging in India [0.03%]
迁移之后的生活——在印度成功老龄化的比较研究
Bittu Mandal,Kalandi Charan Pradhan,Arun Balachandran
Bittu Mandal
Understanding the dynamics of successful aging in India is crucial, especially in the context of a rising aging population. India, being home to one of the largest internal migrant population in the world, presents a unique context to exami...