Alcohol and High-Fat Diet Aggravate Colitis-Induced Liver Injury via Glucocorticoid/IL-6-SAA1 Axis in Mice [0.03%]
酒精和高脂饮食通过糖皮质激素/IL-6-SAA1轴加重小鼠结肠炎相关肝损伤
Mingrui Zhao,Han Li,Xinghua Gao et al.
Mingrui Zhao et al.
Colitis-associated liver injury rarely causes acute mortality, but whether alcohol and a high-fat diet (HFD) aggravate hepatic injury during colitis remains unclear. Here, dextran sulfate sodium (DSS)-induced colitic mice were exposed to al...
The combined effect of early-life Bisphenol A (BPA) exposure and post-weaning high-fat diet on the intestinal health of mice [0.03%]
早期生活阶段双酚A(BPA)暴露与断奶后高脂饮食对小鼠肠道健康联合效应的研究
Shuyang Huang,Jiapeng Huang,Zhiyong Xie et al.
Shuyang Huang et al.
Exposure to bisphenol A (BPA) and long-term high-fat diet (HFD) have been proven to have adverse effects on human health. This study demonstrated that the sequential exposure to BPA in early life and high-fat diet after weaning jointly impa...
Developmental reproductive impacts of gestational polystyrene nanoplastics exposure: precocious puberty and impaired ovarian reserve in female offspring [0.03%]
孕期纳米塑料暴露对生殖发育的影响：女孩第二性征过早发育和卵巢储备功能下降
Junhong Xie,Moxuan Zhao,Baolu Liang et al.
Junhong Xie et al.
Dietary ingestion of nanoplastics through contaminated food and drinking water has become a pressing human health concern. Despite this pressing health concern, the developmental reproductive impacts of gestational nanoplastics exposure on ...
Alternariol, a mycotoxin, induces oxidative stress, inflammation, and apoptosis in human astrocytes: Protective effects of eicosapentaenoic acid [0.03%]
黄曲霉毒素诱导人类星形胶质细胞氧化应激、炎症和凋亡：二十碳五烯酸的保护作用
Che-Sheng Chu,Wei-Chih Sun,Wei-Zhe Liang
Che-Sheng Chu
Alternariol (AOH), a mycotoxin produced by Alternaria species, has been associated with oxidative and inflammatory toxicity, although its effects on astrocytes remain poorly understood. This study investigated AOH-induced cellular responses...
Alternariol mycotoxin affects gut integrity and permeability in porcine epithelial intestinal cell line IPEC-1 [0.03%]
猪肠上皮细胞系IPEC-1中交替胞子毒素影响肠道结构和渗透性
Daniela Eliza Marin,Cristina Valeria Procudin,Iulian Alexandru Grosu et al.
Daniela Eliza Marin et al.
Alternariol (AOH) is a mycotoxin produced by fungi belonging to the genus Alternaria, detected in a large variety of commodities such as cereals, fruits, vegetables, beverages, nuts, and other food products. The present study investigates t...
Adverse outcome pathway frameworks for dietary contaminants: Bridging mechanistic toxicology with regulatory food safety [0.03%]
饮食污染物的不良结果途径框架：连接机制毒理学与监管食品安全问题
Rajesh Pamanji
Rajesh Pamanji
The Adverse Outcome Pathway (AOP) framework has become a powerful tool in mechanistic toxicology, linking molecular initiating events through key biological changes to adverse health outcomes. In food safety, where chronic exposure to diver...
Maternal thyroid axis perturbation following gestational exposure to a syringetin-3-O-glucoside-enriched Syzygium cumini seed isolate in Sprague Dawley rats: Evidence for a sodium/iodide symporter-directed mechanism [0.03%]
妊娠接触Syzygium cumini种子的矢车菊素-3-O-葡萄糖苷富集物后Sprague Dawley大鼠母体甲状腺轴紊乱：钠/碘化物同向转运体介导机制的证据
Arghadip Das,Debdip Sarkar,Priyadharshini Palani et al.
Arghadip Das et al.
Syzygium cumini seed preparations are clinically used during pregnancy for gestational hyperglycaemia, yet the developmental safety of any defined flavonoid glycoside of the species has not been examined in a mammalian model. We examined wh...
Lycopene as a Multi-Target Inhibitor of Ferroptosis: A Narrative Review of Preclinical Evidence and Clinical Prospects [0.03%]
番茄红素作为铁死亡多靶点抑制剂的叙事性综述：临床前证据与应用前景
Mahdieh Sadat Mousavi,Danial Jahantigh
Mahdieh Sadat Mousavi
This narrative review examines lycopene, a natural carotenoid found in tomatoes and other fruits, as a multi-target inhibitor of ferroptosis - an iron-dependent form of regulated cell death driven by lipid peroxidation. Preclinical evidence...
Comparison of food allergic immune responses in sensitized female and male Balb/c mouse induced by Lateolabrax japonicus tropomyosin [0.03%]
牙鲆鱼肌球蛋白诱导BALB/c小鼠过敏模型中雌雄鼠免疫反应的比较研究
Meng-Si Li,Qing-Mei Liu,Fei Xia et al.
Meng-Si Li et al.
Animal models have been widely used to explore the pathogenesis of food allergy. However, the influence of sex differences in mice on food allergy is unknown. In this study, recombinant tropomyosin (TM) exhibited IgE-binding activity compar...
CXCL8 is associated with aflatoxin B1-triggered injury and caspase-3 activation in porcine kidney epithelial PK15 cells: integrated transcriptomics and CRISPR/Cas9 knockout [0.03%]
CXCL8与aflatoxin B1诱导的肾小管上皮PK15细胞损伤和caspase-3激活相关：整合转录组学与CRISPR/Cas9敲除技术研究
Jianlin Yuan,Yuhan Ma,Jinfeng Li et al.
Jianlin Yuan et al.
Aflatoxin B1 (AFB1) is a prevalent food- and feed-borne mycotoxin, and growing evidence indicates that the renal epithelium is a vulnerable target. However, host determinants that modify epithelial susceptibility remain poorly defined. Here...