Integrative single-cell transcriptomics and Mendelian randomization prioritize FN1 and DCN in intervertebral disc degeneration [0.03%]
整合单细胞转录组学和孟德尔随机化在椎间盘退变中优先确定FN1和DCN基因的作用
Zhen Huang,Jing-Jia Liu,Chun Zhao et al.
Zhen Huang et al.
Intervertebral disc degeneration (IDD) is a major contributor to low back pain, yet its cellular heterogeneity and the relevance of circulating extracellular-matrix proteins to disease susceptibility remain incompletely understood. We integ...
Update to RIFM fragrance ingredient safety assessment, propenylguaethol, CAS Registry Number 94-86-0 [0.03%]
RIFM香原料安全评估更新：丙烯基guaethol（CAS号94-86-0）
A M Api,A Bartlett,D Belsito et al.
A M Api et al.
The existing information supports the use of this material as described in this safety assessment. Propenylguaethol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/p...
Update to RIFM fragrance ingredient safety assessment, ethyl 3-hydroxybutyrate, CAS Registry Number 5405-41-4 [0.03%]
RIFM香原料安全评估更新，乙基3-羟基丁酸酯，CAS号5405-41-4
A M Api,A Bartlett,D Belsito et al.
A M Api et al.
A systematic assessment of metal and metalloid migration from food contact materials: Evidence from plastics, metal cookware, stainless steel, ceramics, glass, and paper-board [0.03%]
系统评估食品接触材料中金属和类金属迁移量：塑料、金属厨具、不锈钢、陶瓷、玻璃和纸板中的证据
Mohamed A A Mahmoud,Mahmoud M Ghuniem,Salim A Ali et al.
Mohamed A A Mahmoud et al.
Metal and metalloid migration from food contact materials remains an incompletely characterized chemical hazard. This PRISMA 2020-compliant systematic review synthesized experimental migration data from 69 studies published between 2015 and...
Update to RIFM fragrance ingredient safety assessment, 3-(p-tert-butylphenyl)-2-methylpropanol, CAS Registry Number 56107-04-1 [0.03%]
RIFM香原料安全评估更新，3-(对叔丁基苯基)-2-甲基丙醇，CAS号为56107-04-1
A M Api,A Bartlett,D Belsito et al.
A M Api et al.
Comprehensive analysis of the association between perfluorooctanoic acid exposure and osteosarcoma progression [0.03%]
全氟辛酸暴露与骨肉瘤进展关联的综合分析
Yuru Dong,Jiaxiao Zheng,Xingtong Dong et al.
Yuru Dong et al.
Perfluorooctanoic acid (PFOA), a persistent environmental pollutant, represents a chronic environmental stressor, yet its role in osteosarcoma progression remains unclear. Here, we integrated network toxicology, machine learning, immune inf...
Update to RIFM fragrance ingredient safety assessment, ethyl 3-hydroxyhexanoate, CAS Registry Number 2305-25-1 [0.03%]
RIFM香料原料安全评估更新：乙基3-羟基己酸酯（CAS号2305-25-1）
A M Api,A Bartlett,D Belsito et al.
A M Api et al.
Di(2-ethylhexyl) phthalate exposure aggravates amyloid-beta-induced toxicity in transgenic AD Caenorhabditis elegans via lysosomal dysfunction and oxidative stress [0.03%]
邻苯二甲酸二乙基己酯暴露通过溶酶体功能障碍和氧化应激加剧秀丽隐杆线虫淀粉样蛋白-β诱导的毒性作用
Fan Yang,Yan Zhao
Fan Yang
Di(2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer and environmental contaminant. DEHP exposure has been linked to neurotoxicity in Alzheimer's disease (AD), yet the underlying mechanisms remain unclear. Here we found that DEHP ...
Impact of parabens, individually and in mixture, on human neutrophil oxidative burst under physiological and hyperglycemic conditions [0.03%]
苯氧乙醇及其混合物对生理及高血糖条件下的人类中性粒细胞氧化爆发的影响
Ana Ramalho,Diana Dias da Silva,José Alberto Duarte et al.
Ana Ramalho et al.
Parabens are a family of alkyl esters of 4-hydroxybenzoic acid (4-HB), widely used as antimicrobial agents in various industries, including cosmetics, pharmaceuticals, and food. However, concerns have been raised regarding their potential t...
Environmental benzophenone exposure promotes liver cancer cell proliferation via the IRE1α-XBP1s pathway [0.03%]
环境中的苯酮通过IRE1α-XBP1s途径促进肝癌细胞增殖
Rong Wang,Jing Yang,Kailun Wang et al.
Rong Wang et al.
Humans are widely exposed to benzophenones, ultraviolet absorbers in sunscreens that accumulate in the liver. This study investigated the impact of chronic benzophenone exposure on hepatocellular carcinoma (HCC). We established a long-term ...