Stemness-driven INTS7 overexpression links metabolic comorbidity to chemoresistance in acute myeloid leukemia with type 2 diabetes [0.03%]
以干细胞特性驱动的INTS7过表达将代谢并发性疾病与急性髓系白血病中的化疗耐药联系起来（伴有2型糖尿病）
Mengxian Jin,Yue Yu,Shenyang Zhuang et al.
Mengxian Jin et al.
Background: Acute myeloid leukemia (AML) often coincides with type 2 diabetes mellitus (T2D), yet the impact of metabolic comorbidity on leukaemic biology and prognosis remains underexplored. ...
SLC1A5 and NUMA1 are potential regulators and therapeutic targets of ferroptosis in diffuse large B-cell lymphoma [0.03%]
SLC1A5和NUMA1是弥漫性大B细胞淋巴瘤铁死亡的潜在调控因子和治疗靶点
Tao Qin,Haixi Zhang,Fen Li et al.
Tao Qin et al.
Background: Ferroptosis, a form of regulated cell death driven by iron-dependent lipid peroxidation, has emerged as a potential therapeutic target in various cancers, including diffuse large B-cell lymphoma (DLBCL). This ...
Venetoclax combined with induction chemotherapy is associated with higher MRD-negative remission in adult AML: a single-center retrospective cohort study [0.03%]
伏诺克拉克斯与诱导化疗联合使用可使成人急性髓系白血病获得更高的分子残留病变阴性缓解：一项单中心回顾性队列研究
Tomer Atlas,Meir Pinto Israel,Uri Greenbaum et al.
Tomer Atlas et al.
Feasibility of blinatumomab in newly diagnosed pediatric B-cell acute lymphoblastic leukemia patients requiring modification of standard chemotherapy [0.03%]
适应性调整标准化疗方案后儿童B细胞急性淋巴细胞白血病患者使用Blinatumomab治疗的可行性研究
Wenjuan Wang,Hailing Liu,Yingjie Chen et al.
Wenjuan Wang et al.
Purpose: Newly diagnosed pediatric B-cell acute lymphoblastic leukemia (B-ALL) patients who require modification of standard chemotherapy because of severe treatment-related toxicities or inadequate early response represe...
Ana Maria Marinho da Silva,Valdenizia R Silva,Alython Araújo Chung-Filho et al.
Ana Maria Marinho da Silva et al.
Background: Several studies conducted in high-income countries (HICs) have demonstrated that treatment intensification in pediatric T-cell acute lymphoblastic leukemia (T-ALL) improved survival outcomes. However, studies ...
Arterial stiffness in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitors: An exploratory prospective observational study [0.03%]
慢性粒细胞白血病患者接受酪氨酸激酶抑制剂治疗的动脉僵硬度：一项探索性前瞻性观察研究
Olga Mulas,Alessandro Sestu,Alessandro Costa et al.
Olga Mulas et al.
Arterial stiffness, measured by pulse wave velocity (PWV), is a validated surrogate of vascular damage and CV risk, but evidence on TKI-specific patterns of arterial stiffness and their prognostic relevance in chronic myeloid leukemia (CML)...
Influence of IGF2BP3 on t(4;11) fusion mRNA and protein abundance [0.03%]
IGF2BP3对t(4;11)融合mRNA及蛋白表达的影响研究
Thomas Hanewald,Tamara Benz,Rolf Marschalek
Thomas Hanewald
The chromosomal translocation t(4;11)(q21;q23) is the most common genetic aberration in KMT2A-rearranged acute leukemia. Although the molecular functions of wild-type KMT2A and AFF1 complexes are well characterized, little is known about th...
Socioeconomic and ethnic disparities in radiation therapy utilization for primary bone diffuse large B-cell lymphoma: A SEER population-based study [0.03%]
基于SEER数据库的原发骨弥漫大B细胞淋巴瘤患者放射治疗应用的社会经济及种族差异性分析
Brendon Wang,Irene Wang,Andrew Chen et al.
Brendon Wang et al.
Background: Primary bone diffuse large B-cell lymphoma (PB-DLBCL) is a rare extranodal lymphoma in which consolidative radiation therapy (RT) has demonstrated survival benefit, particularly in early-stage disease. Dispari...
Dose schedule modifications of 5-azacitidine monotherapy in myelodysplastic neoplasias and chronic myelomonocytic leukaemia [0.03%]
5-氮胞苷单药治疗剂量方案在骨髓增生异常类肿瘤及慢性嗜酸性粒细胞白血病中的调整
Gerasimos Tsilimidos,Ribal Bou Mjahed,Ulrich Germing et al.
Gerasimos Tsilimidos et al.
5-azacitidine (5-AZA) is the first hypomethylating agent synthetized and the cornerstone treatment for high-risk myelodysplastic neoplasms (MDS) and chronic myelomonocytic leukaemia (CMML). Although the validated schedule is 75 mg/m2 for 7 ...
Analysis of the efficacy and safety of the IVD/EM maintenance regimen as post-remission treatment for adult patients with T-cell lymphoblastic lymphoma/leukemia [0.03%]
评估IVD/EM方案作为T细胞淋巴母细胞白血病/淋巴瘤成人患者缓解后治疗的有效性和安全性的研究
Ziteng Xie,Yue Song,Yige Zhang et al.
Ziteng Xie et al.
Objective: To analyze the efficacy and safety of ifosfamide + vincristine + dexamethasone/etoposide + mitoxantrone (IVD/EM) regimen as maintenance therapy in adult patients with T-cell lymphoblastic lymphoma/leukemia (T-L...