Oxidative stress induced TSLP production via TRPV4 regulates type 2 inflammation and pruritus in MC903 induced atopic dermatitis mouse model [0.03%]
氧化应激通过瞬时受体电位香草素4调节MC903诱导的特应性皮炎小鼠模型中的胸腺间质淋巴细胞生成素介导的2型炎症和瘙痒感
Keiji Kosaka,Akihiko Uchiyama,Yuta Inoue et al.
Keiji Kosaka et al.
Background: Transient receptor potential vanilloid 4 (TRPV4) is a calcium ion channel that is widely expressed in various cells, and it regulates multiple physiological and pathological processes. In skin, TRPV4 senses te...
VEGFR-2-targeted photoimmunotherapy for psoriasis-like plaques in a mouse model [0.03%]
针对小鼠银屑病斑块的VEGFR-2靶向光免疫疗法
Minako Ogawa-Tominaga,Yozo Ishiuji,Takashi Nishimura et al.
Minako Ogawa-Tominaga et al.
Low-temperature plasma-activated Ringer's lactate solution induces apoptosis in melanoma cells by downregulating heat shock proteins and by inducing mitochondrial dysfunction [0.03%]
低温等离子活化林格氏乳酸盐溶液通过下调热休克蛋白并诱导线粒体功能障碍来诱导黑色素瘤细胞凋亡
Akira Miyazaki,Tomoki Taki,Kae Nakamura et al.
Akira Miyazaki et al.
Background: Low-temperature plasma (LTP) is an essential technology in engineering that originated in materials science. Its applications have recently been expanded to biology, where it is referred to as plasma biology. ...
DcR3 reprograms macrophage plasticity to promote wound healing and hair regeneration [0.03%]
DcR3 重新编程巨噬细胞的可塑性以促进伤口愈合和毛发再生
Shih-Hsun Ou,Yi-Chun Chen,Shie-Liang Hsieh et al.
Shih-Hsun Ou et al.
Background: Macrophages are key regulators of tissue repair, with M2-polarized subsets promoting anti-inflammatory, pro-regenerative functions. Decoy Receptor 3 (DcR3), a soluble TNF receptor superfamily member, modulates...
Salvianolic acid B ameliorate alopecia by simultaneously targeting Wnt/β-catenin and mTORC2/Akt signaling [0.03%]
salvianolic酸B通过同时靶向Wnt/β-catenin和mTORC2/Akt信号通路改善脱发症状
Junjie Cen,Xin Tang,Nan Xu et al.
Junjie Cen et al.
Background: Alopecia is a prevalent clinical condition with currently limited therapeutic options. Salvianolic acid B (Sal B) has demonstrated promising regenerative properties across various disease models. However, its ...
Integrative analysis of bulk multiomics and single-cell transcriptomics reveals the value of neddylation in Skin Cutaneous Melanoma [0.03%]
整合分析组学和单细胞转录组数据揭示蛋白NEDDYLATION修饰在皮肤黑色素瘤中的价值
Li Yang,Yuan Yao,Kexin Shi et al.
Li Yang et al.
Background: Melanoma is recognized as the most aggressive type of skin cancer, characterized by its high mortality rates and significant therapeutic challenges. ...
Comparative analysis of cytotoxic mediators in Stevens-Johnson syndrome and toxic epidermal necrolysis using ex vivo human epidermis [0.03%]
体外培养的人类表皮细胞在史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症中的细胞毒性介质比较分析
Manao Kinoshita,Youichi Ogawa,Yuka Nagasaka et al.
Manao Kinoshita et al.
Erratum to "Transcriptional regulation of Mlph and Rab27a by PAX3-NF-κB interaction in melanosome transport of melanocytes" [J. Dermatol. Sci. 120 (2025) 98-104] [0.03%]
关于“PAX3-NF-κB相互作用在黑色素细胞中对Mlph和Rab27a转录调控在黑素体运输中的作用”的勘误注释
HaiRu Zhao,SeongWon Park,ChanSong Jo et al.
HaiRu Zhao et al.
SMYD2 promotes oxidative stress-responsive lipid metabolism in melanoma by regulating H3K4 tri-methylation [0.03%]
SMYD2通过调控H3K4三甲基化促进黑色素瘤氧化应激响应性脂质代谢
Bing Han,Henan Si,Shuyue Yang et al.
Bing Han et al.
Background: Lipid metabolism is increasingly recognized as a critical role in cancer biology, influencing membrane dynamics, energy homeostasis, and cell survival. In melanoma, the specific regulatory mechanisms linking l...
Adenosine A2A receptors are expressed on the bottom of basal keratinocytes and promote keratinocyte proliferation in human skin [0.03%]
腺苷A2A受体在人皮肤基底角质细胞底部表达并促进表皮角质形成细胞增殖
Kazuki Takagaki,Shinobu Nakanishi
Kazuki Takagaki