Exploring the efficacy evaluation model for androgenic alopecia using hair organoids: Transcending conventional hair research [0.03%]
Seoyeon Kyung,Su Jin Lim,Kyung Eun Lee et al.
Seoyeon Kyung et al.
Background: The development of effective evaluation tools for anti-hair loss therapies is critical due to limitations in existing experimental systems. Hairy 3D skin models and hairy skin explants are not yet commercially...
A possible link between epidermal TRPV4 expression, osmolality, and itch in atopic dermatitis [0.03%]
Atsuko Kamo,Mao Hotta,Mitsutoshi Tominaga et al.
Atsuko Kamo et al.
Identification of novel small molecule compounds with readthrough activity in Nagashima-type palmoplantar keratosis [0.03%]
纳加岛型掌跖角化症读码活性新型小分子化合物的鉴定
Jin Teng Peh,Takato Sugiyama,Risa Nobuta et al.
Jin Teng Peh et al.
Background: Nagashima-type palmoplantar keratosis (NPPK), the most common form of hereditary palmoplantar keratodermas in East Asian populations, is caused by biallelic loss-of-function mutations in SERPINB7 such as p.Arg...
Treg cells as potential therapeutic targets for bullous pemphigoid: A review [0.03%]
调节性T细胞作为大疱性天疱疮的潜在治疗靶点：综述研究
Honghao He,Shiguang Peng,Xinyi Wei et al.
Honghao He et al.
Bullous pemphigoid (BP) is an autoimmune disease characterized by Bullous pemphigoid antigen 180(BP180) and Bullous pemphigoid antigen 230(BP230) autoantibodies production. Regulatory T cells (Tregs) are key cells for the maintenance of imm...
Eribulin promotes dendritic cell activation and migration in the murine tumor microenvironment [0.03%]
厄立替尼促进小鼠肿瘤微环境中的树突状细胞活化和迁移
Kazumasa Oya,Ko Matsuoka,Yoshiyuki Nakamura et al.
Kazumasa Oya et al.
Heparinoid and phospho-pyridoxal preserve tight junction integrity in human skin under oxidative stress [0.03%]
肝素样及焦磷酸吡哆醛通过抗氧化压力来维持人体皮肤紧密连接的完整性
Hiroki Sakamoto,Ryota Asahina,Momoyo Nishikawa et al.
Hiroki Sakamoto et al.
Inhibition of eukaryotic translation initiation factor 1 A (eIF1A) and 3B (eIF3B) diminishes the psoriatic phenotype in two mouse models and human 3D model samples [0.03%]
抑制真核翻译起始因子1A（eIF1A）和3B（eIF3B）可减轻小鼠模型和人类3D样本的银屑病表型
Nicole Golob-Schwarzl,Natalie Bordag,Nitesh Shirsath et al.
Nicole Golob-Schwarzl et al.
Background: Psoriasis is a systemic inflammatory skin disease for which new topical treatments are needed. Psoriatic inflammation is associated with overexpression of eukaryotic translation initiation factors (eIFs), whic...
Single-cell RNA sequencing identifies long non-coding RNAs enriched in psoriatic epidermal subsets [0.03%]
单细胞RNA测序鉴定银屑病表皮亚群富集的长链非编码RNA
Longlong Luo,Jan Cedric Freisenhausen,Devin Malitha Dompage et al.
Longlong Luo et al.
Background: Psoriasis is a chronic inflammatory skin disease characterised by disrupted crosstalk between keratinocytes and immune cells, resulting in epidermal dysfunction. Long non-coding RNAs (lncRNAs) regulate gene ex...
A novel ZIC1-BMP4 axis identified in photoaged dermal fibroblasts regulates melanogenesis [0.03%]
新型的ZIC1-BMP4轴调节光老化真皮成纤维细胞黑素生成
Mengting Ouyang,Feng Zhou,Lei Wen et al.
Mengting Ouyang et al.
Background: Chronic ultraviolet exposure induces photoaging and pigmentation, contributing to disorders such as melasma. However, treatments for photoaging-related pigmentation still challenging, implying upstream regulat...
Parbendazole induces semaphorin 3A expression via JNK/c-Jun signaling pathway in normal human epidermal keratinocytes [0.03%]
帕泊唑胺通过JNK/c-Jun信号通路诱导正常人表皮角质形成细胞中分泌型神经营养因子3A的表达
Mirei Fujita,Yayoi Kamata,Nanami Tanemoto et al.
Mirei Fujita et al.
Background: Epidermal hyperinnervation is a partial cause of antihistamine-resistant itch. The nerve repulsion factor semaphorin 3 A (Sema3A) plays a key role in regulating intraepidermal nerve fiber density. In a prelimi...