A zinc deficiency leads to non-inflammatory pruritus by modifying opioid receptor signaling [0.03%]
缺锌通过改变阿片受体信号通路诱发非炎症性瘙痒
Hozumi Sano,Reiko Kamijima,Mikiro Takaishi et al.
Hozumi Sano et al.
Background: Pruritus is a major unpleasant sensation due to skin inflammation (inflammatory pruritus, IP), or due to a neurological disturbance despite the absence of objective symptoms of inflammation (non-inflammatory p...
Collagen XVIIα1 in skin and hair aging: Mechanisms, stem cell niche regulation, and translational strategies [0.03%]
胶原蛋白XVIIα1与皮肤和毛发衰老：机制、干细胞龛调控及转化策略
Zixuan He,Fenglin Zhuo
Zixuan He
Collagen XVIIα1, encoded by COL17A1 and historically known as BP180/BPAG2, is a type II transmembrane collagen enriched in hemidesmosomes of basal keratinocytes. Through interactions with integrin α6β4, laminin-332 and other dermal-epide...
A shift towards a type I immune response in chronic atopic dermatitis favours an IL-15 dependent tissue resident memory cell niche [0.03%]
慢性特应性皮炎向I型免疫反应转变有利于IL-15依赖的组织驻留记忆细胞生态位
Adewonuola A Alase,Caroline Mann,Antonia Kolb et al.
Adewonuola A Alase et al.
Background: Tissue resident memory (TRM) cells are of interest in chronic inflammatory skin diseases as they are believed to facilitate flares in the same anatomical area. IL-15 is an essential growth factor for the survi...
Psychological stress exacerbates vitiligo via dysregulated proteolysis of substance P and MRGPRX2-dependent mast cell activation [0.03%]
心理压力通过调节紊乱的P物质蛋白水解和MRGPRX2依赖的肥大细胞活化加剧白癜风病情
Meng-Meng Geng,Shi-Jiao Zhang,Xiao-Hui Li et al.
Meng-Meng Geng et al.
Background: The impact of psychological stress on vitiligo progression remains poorly understood. Objective: We investigated the effect...
KRT10-nEDD-superficial: A novel phenotype characterized by vesicles and skin peeling [0.03%]
KRT10-nEDD-浅表型：以水疱和皮肤剥脱为特征的新表型
Norito Ishii,Kwesi Teye,Masahiro Tsutsumi et al.
Norito Ishii et al.
Synergistic enhancement of PD-L1 expression from DNA repair dysfunction and UV exposure in xeroderma pigmentosum: Potential therapeutic role of PD-L1 inhibitors [0.03%]
着色性干皮病中DNA修复功能紊乱和紫外线暴露对PD-L1表达的协同增强作用及其潜在的免疫治疗意义
Yu-Chen Lin,Tzu-Yu Lin,Yung-Chieh Chang et al.
Yu-Chen Lin et al.
Background: Xeroderma pigmentosum (XP) is a rare genetic disorder caused by defective nucleotide excision repair, leading to extreme UV sensitivity and early-onset skin cancers. Although PD-1/PD-L1 inhibitors have shown b...
Genomic deletion upstream of steroid sulfatase eliminates expression of skin-expressed isoforms in X-linked ichthyosis [0.03%]
X连锁鱼鳞病上游基因组的缺失消除了类固醇硫酸酯酶皮肤特异型等位基因的表达
Ivo F Nagtzaam,Laurie C M Kouwenberg,Marieke F van Dooren et al.
Ivo F Nagtzaam et al.
Low Ki-67 marks immunogenic CD8⁺ tissue-resident memory T cell enrichment in vitiligo skin [0.03%]
低Ki-67标志物标记的免疫原性CD8+tissue-resident记忆T细胞在白癜风皮肤中的富集
Jing Wang,Kazunori Yokoi,Shoichi Matsuda et al.
Jing Wang et al.
A SpliceAI-guided workflow for transcript validation using archived formalin-fixed paraffin-embedded skin tissue: Application to ATP2C1 splice-region variation in Hailey-Hailey disease [0.03%]
一种使用存档的福尔马林固定石蜡包埋皮肤组织进行转录本验证的spliceai引导工作流程：ATP2C1剪接区变异在Haileychailey病中的应用
Haruna Goto,Yasuaki Ikuno,Miharu Shibata et al.
Haruna Goto et al.
COMMD3 mediates melanin synthesis through both clusterin-PAX3 axis and copper-dependent tyrosinase activity in skin pigmentation [0.03%]
COMMD3通过clusterin-PAX3轴和铜依赖性酪氨酸酶活性介导皮肤色素沉着中的黑色素合成
Xinyi Huang,Shan Wu,Min Yan et al.
Xinyi Huang et al.
Background: Pigmentation-related disorders mainly revolve around abnormal melanogenesis, but the regulatory mechanisms remain unclear. Recent reports have found that COMMD3 plays a role in promoting melanin synthesis. ...