CXCL14 is a novel biomarker for mast cell infiltration in the melanoma tumor microenvironment [0.03%]
Sanjay Lietzau,Mitchell C Cutler,Mengyan Li et al.
Sanjay Lietzau et al.
Current insights into the metabolic dysregulation of keratinocytes in psoriasis: A review [0.03%]
银屑病发病中角质形成细胞代谢异常的最新研究进展及思考
Jinkang He,Chenjie Liu,Jiayi Li et al.
Jinkang He et al.
Psoriasis is an inflammatory skin disease, which is distinguished by parakeratosis and hyperkeratosis. Abnormal keratinocyte activity is crucial to its onset and development. Recent evidence reveals the significance of metabolic reprogrammi...
ADAMTSL6 contributes to the maintenance of elastic fibers in the papillary dermis and decreases during photoaging in human skin [0.03%]
ADAMTSL6参与人皮肤乳头层弹性纤维的维持并在光老化时减少
Yuko Matsuura-Hachiya,Yuki Ogura,Yuzo Yoshida et al.
Yuko Matsuura-Hachiya et al.
Background: Human skin includes an elastic fiber system consisting of oxytalan, elaunin, and elastin fibers, which are classified based on their fibrillin microfibril and elastin contents. These fibers decrease or lose th...
Proteomic and metabolomic profiling reveals dysregulation of immune states, mucin-type glycosylation and steroid metabolism in extramammary Paget's disease [0.03%]
蛋白质组和代谢组谱分析揭示了额外乳腺Paget病中免疫状态、黏蛋白型糖基化和类固醇代谢的失调
Xinyu Du,Chunxia Zhao,Jie Tian et al.
Xinyu Du et al.
Background: Extramammary Paget's disease is a rare cutaneous adenocarcinoma characterized by mucin-rich Paget cells and chronic inflammation, yet its molecular basis remains unclear. ...
Longitudinal BRAF ctDNA monitoring in melanoma reflects disease status and predicts relapse [0.03%]
纵向BRAF ctDNA监测反映黑色素瘤疾病状态和预测复发
Daniel Rizo-Potau,Anton Forniés-Mariné,Michelle Aguilar et al.
Daniel Rizo-Potau et al.
Background: Early detection of melanoma relapse after curative-intent surgery remains challenging, and routine follow-up relies on imaging and imperfect serum biomarkers. ...
Dongyun Lei,Shiying Li,Litao Zhang et al.
Dongyun Lei et al.
Autophagy, a highly conserved cellular degradation process, is essential for maintaining cellular homeostasis and responding to stress. Recent studies have highlighted the importance of autophagy in regulating epidermal functions, including...
Clinical and immunological profiles of pemphigoid patients negative for CLEIA and positive for ELISA of BP180 NC16A [0.03%]
CLEIA阴性且BP180NC16A ELISA阳性天疱疮患者的临床及免疫学特征分析
Masahiro Tsutsumi,Kwesi Teye,Norito Ishii et al.
Masahiro Tsutsumi et al.
Inflammaging in melanoma: Precision control for optimizing immune checkpoint inhibition [0.03%]
黑色素瘤中的炎症性衰老：精准调控以优化免疫检查点抑制作用
Hisashi Kanemaru,Steven Luong,Yukari Mizukami et al.
Hisashi Kanemaru et al.
Aging is a major risk factor for melanoma and is accompanied by a chronic, low-grade inflammatory state termed "inflammaging". Although inflammation is essential for host defense and antitumor immunity, not all inflammatory states are benef...
K Miyamoto,T Yanagi,H Nishihara et al.
K Miyamoto et al.
Imaging-guided tape stripping reveals consistent stratum corneum profiling of disease severity and treatment-responsive molecular features in pediatric atopic dermatitis [0.03%]
影像引导的胶带剥离法揭示了儿童特应性皮炎疾病严重程度的一致角质层特征以及治疗反应性的分子特征
Daniel Andersen,Oriol Yélamos,Marc Combalia et al.
Daniel Andersen et al.
Background: Atopic dermatitis (AD) is a common pediatric skin disorder with early onset and complex pathophysiology. Tape-strip sampling has enabled minimally invasive molecular profiling of skin lesions in children, yet ...