Adenosine A2A receptors are expressed on the bottom of basal keratinocytes and promote keratinocyte proliferation in human skin [0.03%]
腺苷A2A受体在人皮肤基底角质细胞底部表达并促进表皮角质形成细胞增殖
Kazuki Takagaki,Shinobu Nakanishi
Kazuki Takagaki
Cyclin E1 is dispensable for skin homeostasis and hyperplasia but is essential for carcinogenesis [0.03%]
Cyclin E1对于皮肤稳态和增生是不需要的，但对于致癌性是必不可少的
Lizbeth Contreras,Ana Marcos-Díaz,Lorena García-Gaipo et al.
Lizbeth Contreras et al.
Background: Epidermal renewal needs tight control of the cell cycle and proliferation to face the continuous mutagenic pressure of UV light. Cyclin E1 is a key molecule in human epidermis, a main driver of the cell cycle ...
Bead aggregation assays with desmoglein and desmocollin for the evaluation of disease activity in pemphigus [0.03%]
用于评估天疱疮疾病活动性的desmoglein和desmocollin珠串聚合实验
Miki Hamanaka,Ken Ishii,Mari Urushibata et al.
Miki Hamanaka et al.
Background: Previously, we developed bead aggregation assays with recombinant desmoglein (Dsg) and desmocollin (Dsc) and found that pemphigus autoantibodies directly block the heterophilic trans-interaction of Dsg/Dsc. ...
Transcriptional regulation of Mlph and Rab27a by PAX3-NF-κB interaction in melanosome transport of melanocytes [0.03%]
PAX3-NF-κB相互作用在黑色素细胞中调控Mlph和Rab27a的转录从而影响黑色素体运输
HaiRu Zhao,SeongWon Park,ChanSong Jo et al.
HaiRu Zhao et al.
Background: Melanosome transport is a highly coordinated process involving both microtubule- and actin-dependent mechanisms. Our previous study identified 2-methyl-naphtho[1,2,3-de]quinolin-8-one (MNQO) as an inhibitor of...
Three-dimensional cultured human skin model replicating a human facial shape enables personalized assessment of UVB damage in various facial areas [0.03%]
三维人体皮肤模型再现人脸形状可在不同面部区域进行个性化UVB损伤评估
Katsuma Miyachi,Takaaki Yamada,Takeru Siraishi et al.
Katsuma Miyachi et al.
Molecular profile of interleukin-17RA blockade by brodalumab in Japanese patients with psoriasis: Results from the ESPRIT study [0.03%]
日本ESPRIT研究中布罗利单抗阻断银屑病患者白细胞介素-17RA的分子谱特征：研究结果
James G Krueger,Akimichi Morita,Mona Uchida-Yamada et al.
James G Krueger et al.
Background: Brodalumab, an anti-interleukin-17 receptor A antibody, is effective in psoriasis via action on the IL-17 pathway. Objective: ...
A case of metastatic breast carcinoma to the skin expressing SARS-CoV-2 spike protein possibly derived from mRNA vaccine [0.03%]
一例皮肤转移性乳腺癌表达新冠病毒刺突蛋白的病例或由mRNA疫苗引起
Shigetoshi Sano
Shigetoshi Sano
A reappraisal of type 2 cytokine-producing cells in atopic dermatitis: Spotlight on Tc2 cells [0.03%]
特应性皮炎中产生2型细胞因子的细胞再评价：Tc2细胞研究焦点
Tetsuya Honda
Tetsuya Honda
Atopic dermatitis (AD) is a chronic inflammatory skin disorder driven by type 2 cytokines, particularly IL-4, IL-13, and IL-31. CD4⁺ Th2 cells have long been considered the primary producers of these cytokines in AD, but the contribution o...
Foxp3-ablation/melanoma-induced vitiligo: An enhanced mouse model [0.03%]
一种增强型小鼠模型：Foxp3缺失/黑色素瘤诱导的白癜
Shiyu Jin,Sheng Wan,Xiuzu Song et al.
Shiyu Jin et al.
Regulation of melanogenesis via ubiquitin-proteasome system and autophagy by 3,3,5-trimethylcyclohexyl succinate dimethylamide and tranexamic acid [0.03%]
3,3,5-三甲基环己基琥珀酸二甲胺和氨甲环酸通过泛素-蛋白酶体系统及自噬调节黑色素生成
Jing Wang,Fanglan Zha,Simin Lin et al.
Jing Wang et al.
Background: Excessive melanogenesis in skin melanocytes results in hyperpigmentation disorders. Objective: This study investigates the ...