Inhibition of eukaryotic translation initiation factor 1 A (eIF1A) and 3B (eIF3B) diminishes the psoriatic phenotype in two mouse models and human 3D model samples [0.03%]
抑制真核翻译起始因子1A（eIF1A）和3B（eIF3B）可减轻小鼠模型和人类3D样本的银屑病表型
Nicole Golob-Schwarzl,Natalie Bordag,Nitesh Shirsath et al.
Nicole Golob-Schwarzl et al.
Background: Psoriasis is a systemic inflammatory skin disease for which new topical treatments are needed. Psoriatic inflammation is associated with overexpression of eukaryotic translation initiation factors (eIFs), whic...
Single-cell RNA sequencing identifies long non-coding RNAs enriched in psoriatic epidermal subsets [0.03%]
单细胞RNA测序鉴定银屑病表皮亚群富集的长链非编码RNA
Longlong Luo,Jan Cedric Freisenhausen,Devin Malitha Dompage et al.
Longlong Luo et al.
Background: Psoriasis is a chronic inflammatory skin disease characterised by disrupted crosstalk between keratinocytes and immune cells, resulting in epidermal dysfunction. Long non-coding RNAs (lncRNAs) regulate gene ex...
A novel ZIC1-BMP4 axis identified in photoaged dermal fibroblasts regulates melanogenesis [0.03%]
新型的ZIC1-BMP4轴调节光老化真皮成纤维细胞黑素生成
Mengting Ouyang,Feng Zhou,Lei Wen et al.
Mengting Ouyang et al.
Background: Chronic ultraviolet exposure induces photoaging and pigmentation, contributing to disorders such as melasma. However, treatments for photoaging-related pigmentation still challenging, implying upstream regulat...
Parbendazole induces semaphorin 3A expression via JNK/c-Jun signaling pathway in normal human epidermal keratinocytes [0.03%]
帕泊唑胺通过JNK/c-Jun信号通路诱导正常人表皮角质形成细胞中分泌型神经营养因子3A的表达
Mirei Fujita,Yayoi Kamata,Nanami Tanemoto et al.
Mirei Fujita et al.
Background: Epidermal hyperinnervation is a partial cause of antihistamine-resistant itch. The nerve repulsion factor semaphorin 3 A (Sema3A) plays a key role in regulating intraepidermal nerve fiber density. In a prelimi...
Elevated serum d-ROMs and lesional 4-HNE expression indicate oxidative stress in pemphigus [0.03%]
血清d-ROMs升高和皮损中4-HNE表达增高提示自身免疫性大疱病存在氧化应激
Chisato Tawada,Ryota Asahina,Yoko Ueda et al.
Chisato Tawada et al.
Characterization of a unique pathogenic variant in the SERPING1 gene of a patient with hereditary angioedema type I [0.03%]
SERPING1基因新突变导致的赫氏血管性水肿I型一例及文献复习
Takafumi Hisamoto,Kenta Sentoku,Yutaka Shimomura
Takafumi Hisamoto
Background: Hereditary angioedema (HAE) is a rare genetic disease characterized by sudden onset of edema involving various organs. Among the three subtypes of the disease, HAE types I and II are caused by heterozygous var...
High-throughput sequencing of T-cell receptor beta reveals race and ethnic disparities in cutaneous T-cell lymphoma [0.03%]
高通量T细胞受体β链测序揭示了皮肤T细胞淋巴瘤中的种族和族裔差异
Liliana Crisan,Lu Chen,Michelle Afkhami et al.
Liliana Crisan et al.
Hsa-microRNA-34a-5p inhibits virus-negative Merkel cell carcinoma cell proliferation and migration by regulating cell cycle- and EMT-related pathways and suppresses tumor spheroid formation [0.03%]
Hsa-mir-34a-5p通过调节细胞周期和EMT相关途径抑制病毒阴性默克尔细胞癌细胞增殖和迁移并抑制肿瘤球体形成
Giada Badiale,Christian Felice Cervellera,Giulia Tonnini et al.
Giada Badiale et al.
Background: The molecular mechanisms of Merkel cell polyomavirus (MCPyV)-negative MCC (VN-MCC) initiation remain poorly understood. Although hsa-miR-34a-5p dysregulation has been reported in MCC, its role in VN-MCC is unk...
Comprehensive analysis of tonsillar gene expression and the tonsillar microbiota in patients with palmoplantar pustulosis and pustulotic arthro-osteitis [0.03%]
掌跖脓疱病和关节骨炎患者扁桃体基因表达及扁桃体微生物群的综合分析
Satomi Kobayashi,Hideki Nakagawa,Masato Komai
Satomi Kobayashi
Background: Tonsillectomy improves symptoms in patients with palmoplantar pustulosis (PPP) and suppresses disease progression in patients with pustulotic arthro-osteitis (PAO), highlighting the important role of tonsils i...
Classifying novel DSG1 variants on disease severity in SAM syndrome and palmoplantar keratoderma [0.03%]
DSG1新变异型对SAM综合征和掌跖角化病严重程度的分类作用
Vanya S V J Rossel,Jaap J A J van der Velden,Renske Janssen et al.
Vanya S V J Rossel et al.
Background: Biallelic pathogenic variants in DSG1 encoding desmoglein 1 cause severe atopic dermatitis, multiple allergies, and metabolic wasting (SAM) syndrome, whereas heterozygous variants result in palmoplantar kerato...