Targeting the Tumor Extracellular Matrix: A New Frontier in Cancer Therapy [0.03%]
靶向肿瘤细胞外基质：癌症治疗的新前沿
Anjana Goel,Istuti Saraswat,Swadha Pandey
Anjana Goel
The extracellular matrix (ECM) is a dynamic and multifaceted component of the cellular environment, playing a crucial role in regulating cell behavior, tissue architecture, and overall homeostasis. In the context of cancer, the ECM function...
CDK Inhibition in Lung Cancer Alters Epithelial-Mesenchymal Transition, Autophagy, and Metabolism [0.03%]
肺癌中细胞周期依赖性激酶抑制剂的调控作用改变了上皮间质转化、自噬及代谢
Azizeh Alsayyid,Rose Ghemrawi,Nour Sammani et al.
Azizeh Alsayyid et al.
Introduction: Lung cancer remains the leading cause of cancer-related mortality worldwide, responsible for over 1.8 million deaths annually. Despite therapeutic advancements, clinical outcomes in advanced lung adenocarcin...
Rama Tyagi,Vikram Sharma,Kalpesh Yeole et al.
Rama Tyagi et al.
Recent advancements in melanoma treatment have reinvigorated hope among patients, significantly shifting the therapeutic landscape. A significant advancement in patient outcomes has been realised by applying first-line treatment strategies ...
Therapy-Induced Cellular Senescence in Non-Hodgkin Lymphomas, with Emphasis on Aggressive B-Cell Subtypes: Molecular Mechanisms and Emerging Drug Targets [0.03%]
非霍奇金淋巴瘤中治疗引起的细胞衰老：以侵袭性B细胞亚型为重点，分子机制和新兴药物靶点
Victor Tomacinschii,Andreea Casian,Maria Robu et al.
Victor Tomacinschii et al.
Introduction/background: Therapy-Induced Senescence (TIS) is increasingly recognized as a clinically relevant outcome of anticancer therapy, particularly after sublethal genotoxic stress. In Non-Hodgkin Lymphomas (NHL), T...
Comparing Cisplatin Sensitivity in Conventional 2D Versus Biomaterialfree 3D Spheroid Cultures of Human Cancer and Bone Marrow Stromal Cells [0.03%]
人癌细胞和骨髓基质细胞的二维单层培养与三维球体培养中顺铂敏感性的比较研究
Ceri-Anne Suurmond,Zhule Wang,Jose Kooloos et al.
Ceri-Anne Suurmond et al.
Objective: Bone metastases represent a devastating complication of primary cancers, significantly impacting patient survival and quality of life. Accelerating the development of novel and effective chemotherapeutic drugs ...
Exploring the Tumor Microenvironment: Immuno-Genotoxic Biomarkers at the Forefront of Cancer Diagnosis and Therapy [0.03%]
探索肿瘤微环境：免疫-基因毒性生物标志物在癌症诊断和治疗中的前沿地位
Muhammad Muddassir Ali,Asad Ullah,Ibrahim Hakki Cigerci
Muhammad Muddassir Ali
NRF2-Driven CARM1 Promotes Malignant Progression and Ferroptosis Resistance in Breast Cancer [0.03%]
NRF2驱动的CARM1促进乳腺癌恶性进展和铁死亡抵抗
Yin Zhang,Yinan Guan,Hao Yu et al.
Yin Zhang et al.
Background: CARM1 has attracted significant attention due to its role in carcinogenesis across a variety of cancers. Ferroptosis has emerged as a prospective target in anticancer therapy. ...
MiR-4295 Attenuates the Sensitivity of Gastric Cancer Cells to Chemotherapy Drugs by Inhibiting BCL2L11 [0.03%]
microRNA-4295通过抑制BCL2L11降低胃癌细胞对化疗药物敏感性
Xiaoyan Yang,Liushan Wei,Yuhui Feng et al.
Xiaoyan Yang et al.
Introduction: miRNA is a small intranuclear noncoding RNA, approximately 22 nucleotides (nt), that is aberrantly expressed in tumor cells and tissues. They play important regulatory roles in cell proliferation and chemose...
FDFT1 Suppresses Ovarian Tumorigenesis and Overcomes Cisplatin Resistance by Activating Ferroptosis Through the NRF2/GPX4/SLC7A11 Axis [0.03%]
FDFT1通过激活NRF2/GPX4/SLC7A11轴的铁死亡抑制卵巢肿瘤的发生和发展及克服顺铂耐药性
Yu Jiang,Pincheng Li,Ximu Xiao et al.
Yu Jiang et al.
Introduction: Ovarian cancer's lethality stems from late-stage diagnosis and chemoresistance. Ferroptosis induction represents a promising strategy to overcome platinum resistance. Farnesyl diphosphate farnesyltransferase...
Downregulation of TIMP1 Promotes Ferroptosis and Suppresses Proliferation and Migration of Gastric Cancer Cells via Modulation of the PI3K/AKT Pathway [0.03%]
TIMP1下调通过调节PI3K/AKT途径促进胃癌细胞铁死亡并抑制胃癌细胞增殖和迁移
Yan Kang,Yaoqi Li,Tianxiang Liu et al.
Yan Kang et al.
Introduction: Tissue inhibitor of metalloproteinase 1 (TIMP1) is essential for the development and progression of various cancers and represents a valuable prognostic indicator. ...