Pro-Tumorigenic Roles of Cyclin Dependent Kinase 2 and its Associated Cyclins in Cholangiocarcinoma Progression under High Glucose Condition [0.03%]
高血糖条件下cyclin依赖性激酶2及其相关细胞周期蛋白在胆管癌发生发展中的促肿瘤作用
Cheerapinya Taebprakhon,Supannika Sorin,Kullanat Khawkhiaw et al.
Cheerapinya Taebprakhon et al.
Background: Previous studies have shown that hyperglycemia upregulates cyclin-dependent kinase 2 (CDK2) and its cyclin partners, cyclin E and cyclin A, in cholangiocarcinoma (CCA). However, the effects of targeting these ...
Pirfenidone as a Pleiotropic Antifibrotic Agent in Metabolic Steatohepatitis: From Mechanisms to Clinical Evidence [0.03%]
吡非尼酮作为代谢性 steatohepatitis 的多效抗纤维化药物：从机制到临床证据
Mariana M Ramírez-Mejía,Guadalupe Ponciano-Rodríguez,Jorge L Poo et al.
Mariana M Ramírez-Mejía et al.
Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive phenotype of steatotic liver disease that can lead to advanced fibrosis, cirrhosis and liver-related complications. Pirfenidone is a small synthetic molecule that was ...
Mechanisms of Chemoresistance in Malignant Pleural Mesothelioma: The Regulatory Role of miRNAs [0.03%]
恶性胸膜间皮瘤的化疗耐药机制：miRNA的作用规律
Andrea Martinez-Marroquin,Javier Gaytán-Cervantes,Haydeé Rosas-Vargas et al.
Andrea Martinez-Marroquin et al.
Malignant pleural mesothelioma (MPM), is a rare and aggressive cancer that originates in the mesothelium lining the lungs. It is considered an occupational disease associated with exposure to asbestos in the workplace. MPM is often diagnose...
Viewpoint: Beyond Glycated Hemoglobin-The Frontier of Novel Biomarkers in Diabetes Care [0.03%]
视点： glycated hemoglobin之外——糖尿病治疗中新生物标志物的前景
Yashendra Sethi,Inderbir Padda,Siddharth Gosavi et al.
Yashendra Sethi et al.
Cardiomyopathy in Northwestern Mexico: Clinical Spectrum, Morphological Variants, and Sarcomere Gene Mutations [0.03%]
墨西哥西北部的心肌病：临床谱系，形态学变异和细肌丝基因突变
Cyntia Zulema Machain-Leyva,Cuitláhuac Arroyo-Rodríguez,Luis Alejandro Padilla-Islas et al.
Cyntia Zulema Machain-Leyva et al.
Background: Hypertrophic cardiomyopathy (HCM) is a common genetic heart disease characterized by left ventricular (LV) hypertrophy that cannot be fully explained by abnormal loading conditions. ...
First 1,000 Days of Life Have a Direct Impact on Health: A Mexican Strategy [0.03%]
人生前一千日对其健康状况有直接影响：一项墨西哥战略
Victoria Ramirez,Itzel Kim,Regina J Bautista et al.
Victoria Ramirez et al.
Chronic non-communicable degenerative diseases are the leading cause of mortality, morbidity, and disability in Mexico and worldwide, negatively impacting national economies by consuming health and social resources. These diseases include h...
Decoding the Mutational Hierarchy of Thyroid Cancer and Associated Signaling Pathways [0.03%]
甲状腺癌的突变层级及其相关信号通路解析
Disha Nashier,Gowrang Kasaba Manjunath,Alisha Parveen et al.
Disha Nashier et al.
Background: Thyroid cancer (TC) is the most prevalent endocrine malignancy, and its development is influenced by various genomic abnormalities. Activating mutations in oncogenes such as BRAF and RAS significantly contribu...
Symbiotic (L. acidophilus and Agave Inulin) Prevents Cognitive Impairment in High-Fat Diet/STZ Rats [0.03%]
共生（乳双歧杆菌和虎杖提取物）可改善高脂饮食/链脲佐菌素致大鼠认知障碍的作用研究
Alejandra Romo-Araiza,Luis A Márquez,Gabriela Rocha-Botello et al.
Alejandra Romo-Araiza et al.
Background: Type 2 diabetes has been linked to oxidative stress, inflammation, and an imbalance in the gut microbiota, all of which contribute to neuroinflammation and cognitive decline. Gut microbiota influence inflammat...
Epidemiologic Characterization and Risk Factors of Rocky Mountain Spotted Fever in Children in Northeastern Mexico: A Retrospective Cross-sectional Study (2018-2024) [0.03%]
墨西哥东北部儿童落基山斑点热的流行病学特征及危险因素：一项回顾性横断面研究（2018-2024年）
José Iván Castillo Bejarano,Érika Aidé Larragoity González,Susana Patricia Cantú González et al.
José Iván Castillo Bejarano et al.
Background: Rocky Mountain spotted fever (RMSF) is a vector-borne disease with nonspecific symptoms, including fever, headache, myalgia, and exanthema, which complicates timely diagnosis and treatment. Despite its signifi...
Long-term Outcomes of Psoriatic Arthritis in Daily Practice: Results from a Real World Cohort [0.03%]
真实世界队列中的银屑病关节炎长期结局研究
Alireza Khabbazi,Amir Jamshidi,Nasrin Moghimi et al.
Alireza Khabbazi et al.
Aim: This study aimed to investigate the outcomes of psoriatic arthritis (PsA) and its influencing factors in real-world practice. Methods: ...