Maternal Immune Activation and Postnatal Anoxia Impair Olfactory Discrimination and Increase Oxidative Stress in the Olfactory Bulb of Wistar Rats [0.03%]
母体免疫激活和产后缺氧损害Wistar大鼠的嗅觉辨别能力并增加嗅球中的氧化压力
Henrique José Cavalcanti Bezerra Gouveia,Raul Manhães-de-Castro,Osmar Henrique Dos Santos-Júnior et al.
Henrique José Cavalcanti Bezerra Gouveia et al.
Background: Maternal immune activation (MIA) during pregnancy is associated with the development of neurodevelopmental diseases and psychiatric disorders. Early perinatal inflammation also increases the vulnerability of n...
Triple Harm of Malnutrition and Mental Health in Low- and- Middle Income Countries: After COVID-19 [0.03%]
后新冠疫情时代发展中国家的营养及精神健康的三重危害
María F Mujica-Coopman,Miguel Cordero,Camila Corvalán
María F Mujica-Coopman
Low- and- middle income countries (LMICs), particularly in Latin America, face a growing double burden of malnutrition, characterized by the coexistence of obesity and micronutrient deficiencies alongside high rates of mental health disorde...
Molecular Prenatal Diagnosis of Monogenic Diseases, Towards Non-invasive Procedures [0.03%]
单基因疾病的分子产前诊断向无创程序发展
Camille Verebi,Juliette Nectoux,Thierry Bienvenu
Camille Verebi
In this narrative review, we outline the historical progression of, and modern advancements in, prenatal diagnosis for monogenic diseases. Initially dependent on invasive sampling procedures, prenatal diagnosis has evolved through the integ...
Multi-Omics Integration in Clinical Practice for the Identification of Genetic Variants in Rare Diseases [0.03%]
整合 omics 在临床实践中识别罕见疾病遗传变异的方法
Jonathan Olival,Jordi Pijuan,Natàlia Caelles-Gramunt et al.
Jonathan Olival et al.
One of the main challenges in the field of rare diseases (RDs) remains the persistent lack of timely and accurate diagnoses. Currently, it is estimated that over half of patients remain undiagnosed. The recent development of high-throughput...
Variant Curation and Classification in Rare Disease Genomics: Standards and Emerging Tools for Single-Nucleotide Variant Analysis [0.03%]
罕见疾病基因组学中变异解读与分类：单核苷酸变异分析的标准和新兴工具
Jimena Barraza García,Marta García,Leire Echepare Olivera et al.
Jimena Barraza García et al.
The widespread adoption of next-generation sequencing (NGS) for rare disease diagnosis has transformed clinical genomics. Multiple approaches have been proposed to standardize and improve the analysis, classification, interpretation, and re...
Neonatal Overnutrition-Induced Adiposity and Glucose Intolerance are Associated with Impaired Lipolytic and Insulin Signaling in Adipose Tissue [0.03%]
neonatal过营养诱导的肥胖和葡萄糖耐受不良与脂肪组织脂解和胰岛素信号受损有关
Camila F de Souza,Larissa Rugila S Stopa,Andressa B Martins et al.
Camila F de Souza et al.
Background: Neonatal overnutrition induced by litter size reduction leads to obesity from childhood until adulthood. Increased adiposity in white adipose tissue (WAT) and glucose intolerance are obesity-related comorbidit...
Association between Physical Activity and Accelerated Aging Using S-Anthropoage: A Secondary Analysis of the Mexican Health and Aging Study [0.03%]
基于墨西哥健康与老化研究的S-人类衰老评估法和体力活动关系的二次分析
Julio M Fernandez-Villa,Mariana González-Lara,Omar Yaxmehen Bello-Chavolla et al.
Julio M Fernandez-Villa et al.
Background: Aging clocks estimate biological age (BA) using different measures. One novel way to measure it is to use AnthropoAge and S-AnthropoAge, which use sex-dependent body composition measures to predict 10 year all...
A New Paradigm in Peptide Therapeutics: Defining Dual-Acting Peptide Immuno-Cellular Modulators [0.03%]
肽药物治疗的新范例：双重作用肽免疫细胞调节剂的定义
Sandra D Calixto-Tlacomulco,Ismael Luna-Reyes,Gloria Stephanie Villa-Jaimes et al.
Sandra D Calixto-Tlacomulco et al.
Biofilm and blaOXA-40 Co-Production: A Key Pathogenic Strategy in Hospital-Adapted Pseudomonas aeruginosa [0.03%]
生物被膜和blaOXA-40协同产生：医院适应型铜绿假单胞菌的关键致病策略
Hossein Ghahremanpour,Amin Talebi Bezmin Abadi,Abbas Ali Imani Fooladi
Hossein Ghahremanpour
Background: The coexistence of both carbapenem resistance and biofilm formation in Pseudomonas aeruginosa represents a major clinical challenge, particularly in intensive care units (ICUs). This study investigated antimic...
Response to: "Synovial Fluid Autoantibodies and Cytokines in Rheumatoid Arthritis: Potential Biomarkers and Insight into Disease Pathogenesis" [0.03%]
对“类风湿关节炎滑膜液自身抗体和细胞因子：潜在生物标志物及疾病发病机制的见解”的回复
Shiyao Wu,L I Wang,Honglin Zhu et al.
Shiyao Wu et al.