Pharmacological modulation of anxiety-like behavior by flumazenil, midazolam, and ketamine in rats: Evidence from aversive ultrasonic vocalizations and elevated plus maze [0.03%]
氟马泽林、咪达唑仑和氯胺酮药理学调节大鼠类似焦虑的行为：来自厌恶超声波信号和高架十字迷宫实验的证据
Marcela Unterspann,Chrysostomos Charalambous,Martin Votava et al.
Marcela Unterspann et al.
Anxiety- and stress-related disorders are commonly treated using combinations of centrally acting drugs. However, the behavioral outcomes of interactions between GABAergic and glutamatergic systems remain incompletely characterized. The pre...
Discriminative stimulus and locomotor activity profiles of nicotine and varenicline [0.03%]
尼古丁和伐尼克兰的辨别刺激作用及运动活性特征
Nana Kofi Kusi-Boadum,Cynthia M Taylor,Ritu A Shetty et al.
Nana Kofi Kusi-Boadum et al.
Rationale: These studies characterized the locomotor and discriminative stimulus effect of nicotine, mecamylamine, and varenicline in efforts to optimize detection of substitutes and antagonists of nicotine. ...
Sex differences among adult and adolescent rats in METH-induced CTA with extended CS-US trace intervals [0.03%]
成年和青少年大鼠在延长条件性抑制模型中形成的甲基苯丙胺致恶心的性别差异研究
Ryan T Lacy,Steven B Harrod,Marina H Frayberg et al.
Ryan T Lacy et al.
Recent data show a dramatic increase in stimulant use in the past five years. Amidst this rise, methamphetamine (METH) use is contributing to increases in stimulant overdose deaths. Understanding factors that contribute to stimulant use are...
The silent weight of stress: A bio-psycholinguistic loop of cortisol, control, and the language of the self [0.03%]
沉默的压力重量：皮质醇、控制感与自我语言的生物-心理-语言学循环
Hassan Mahmood,Sobia Noreen
Hassan Mahmood
Chronic stress involves a dynamic interplay of endocrine physiology, neural circuitry, and language. Sustained dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, the body's natural alarm system, results in loss of cortisol rhyt...
Para-chlorophenylalanine induces multidimensional affective-like behaviors in adult zebrafish [0.03%]
对氯苯丙氨酸诱导成年斑马鱼多维度情感样行为
Rossano M Silva,Cássio M Resmim,João V Borba et al.
Rossano M Silva et al.
Affective disorders, such as depression and anxiety, pose major challenges to mental health worldwide. Serotonergic dysfunction has been widely implicated in their pathophysiology, although its contribution involves complex and context-depe...
Congenital Kir6.2 deficiency, but not acute KATP channel blockade, attenuates apomorphine-induced locomotor activity in mice [0.03%]
先天性Kir6.2缺陷，而不是急性KATP通道阻断，可减弱小鼠左旋阿扑吗酯引起的运动活动
Atsumi Mochida-Saito,Akira Umeda,Yasumasa Okada et al.
Atsumi Mochida-Saito et al.
Kir6.2, a pore-forming subunit of adenosine triphosphate-sensitive potassium (KATP) channels, is expressed in dopaminergic neurons, which play critical roles in motor regulation and psychiatric disorders. Although Kir6.2 deficiency has been...
The abuse-related effects of illicitly manufactured fentanyls (IMFs): A mini review [0.03%]
关于非法制造芬太尼类物质致滥用作用的综述性研究
Jeremy R Canfield,Jon E Sprague
Jeremy R Canfield
Illicitly manufactured fentanyls (IMFs) continue to drive opioid morbidity and mortality, yet their abuse-related effects vary widely across analogs. Here, we review preclinical evidence from drug discrimination, conditioned place preferenc...
Acute elevation of anandamide and 2-AG levels modulates defensive behavior in a sex- and strain-dependent manner in an animal model of attention-deficit/hyperactivity disorder [0.03%]
在注意缺陷多动障碍动物模型中，安那度胺和2-AG水平的急性升高以性别和品系依赖的方式调节防御行为
Daniel Bussinger de Souza Penna,Samara Gumiéro Costa,Gabriel Ferreira Dos Santos et al.
Daniel Bussinger de Souza Penna et al.
Attention-deficit/hyperactivity disorder (ADHD) is linked to heightened risk-taking tendencies. Core symptoms and traits, such as impulsivity, hyperactivity, and risk-taking, stem from dysfunctions in frontostriatal circuitry. The endocanna...
Temporal dynamics of PDE4 inhibition in modulating novel object recognition memory consolidation and reconsolidation [0.03%]
PDE4抑制在调节新奇物体识别记忆巩固和再巩固的动态变化中的作用
Jeferson Machado Batista Sohn,Letícia Guidi Ramalho,Jos Prickaerts et al.
Jeferson Machado Batista Sohn et al.
Object recognition memory (ORM) allows individuals to discriminate between familiar and novel stimuli, providing a fundamental model for studying non-emotional memory in rodents. ORM reactivation during retrieval in the presence of a new ob...
Acute food deprivation attenuates methamphetamine-induced locomotor sensitization and decreases glucose, insulin, and Akt levels in rats [0.03%]
急性断食可减轻安非他明致大鼠运动敏感性并降低血糖、胰岛素及Akt水平
Juan C Jiménez,Jorge Miranda-Barrientos,Mireya Becerra-Díaz et al.
Juan C Jiménez et al.
Amphetamine (AMPH) and methamphetamine (METH) are known to enhance dopaminergic signaling in the brain reward system by promoting dopamine release through reversal of dopamine transporter (DAT) function. However, accumulating evidence indic...