Protocadherin 10, a member of cadherin superfamily, increases stress-susceptibility in chronic unpredictable stress-treated rats [0.03%]
cadherin超家族成员原钙粘蛋白10通过增加慢性不可预知性应激处理大鼠的应激易感性促进其抑郁样行为症状发生
Xin-Mu Li,Ning-Ning Zhang,Xiao-Ling Zhang et al.
Xin-Mu Li et al.
Depression is a debilitating disorder influenced by individual variation in stress susceptibility. The identification of stress-sensitive and stress-resistant phenotypes is critical for understanding its pathogenesis. We previously identifi...
The role of short-chain fatty acids and neuroinflammation in PTSD pathogenesis: A gut microbial perspective [0.03%]
从肠道微生物角度探究短链脂肪酸和神经炎症在PTSD发病机制中的作用
Qian-Zhong Song,Bing-Yao Liu,Si-Wei Wang et al.
Qian-Zhong Song et al.
Exposure to severe psychological trauma is a recognized etiological precursor to post-traumatic stress disorder (PTSD), a potentially debilitating psychiatric condition. Increasing evidence indicates a strong connection between mental disor...
Behaviour of female mice defeated in an inter-female aggression protocol predicts resilience to cocaine-induced conditioned place preference [0.03%]
在雌性间攻击行为试验中败北的雌鼠对未来可卡因条件位置偏好的抵抗能力的预测作用
María Ángeles Martínez-Caballero,Claudia Calpe-López,María Pilar García-Pardo et al.
María Ángeles Martínez-Caballero et al.
Several studies have demonstrated that exposure to different protocols of social defeat induces anxiety- and depression-like symptoms in male and female mice. Moreover, male mice exposed to an intermittent social defeat (ISD) show increased...
The SIRT1-HMGB1 pathway in hippocampal microglia is involved in chronic heroin-induced cognitive impairment [0.03%]
海马小胶质细胞中的SIRT1-HMGB1通路参与慢性海洛因所致的认知障碍
Chunlu Li,Yujie Wei,Dan Yin et al.
Chunlu Li et al.
Recent studies have found that microglia-mediated hippocampal damage may be involved in cognitive impairment induced by chronic heroin treatment. However, its specific molecular mechanism remains unclear. This study explored the possible ro...
High doses of orally administered cannabigerol produce deficits in sustained attention in female rats [0.03%]
高剂量的口服麻椒花素可导致雌性大鼠持续注意力缺陷
Catherine F Moore,Cecilia L Bergeria,Cristina Sempio et al.
Catherine F Moore et al.
Cannabigerol (CBG) is a phytocannabinoid found in cannabis that is increasingly being sold and used as an isolate product or as the dominant cannabinoid in cannabis products for purported cognitive enhancement (attention, focus, and memory)...
Evidence of heterogeneity in the opioid withdrawal syndrome: Spontaneous and precipitated withdrawal [0.03%]
阿片类药物戒断综合征异质性证据：自发性和诱发性戒断症状的对比研究
Suky Martinez,Jermaine D Jones,Kelly E Dunn et al.
Suky Martinez et al.
Aims: This study characterized the heterogeneity of opioid withdrawal by comparing naturally occurring withdrawal during opioid abstinence (spontaneous withdrawal) with abrupt, pharmacologically induced naloxone-precipita...
Eutylone history selectively impacts the rewarding and aversive effects of cocaine, MDMA, and eutylone in female Sprague-Dawley rats [0.03%]
1-环己基-2-(苯甲酰胺)哌啶(尤梯隆)史用情况选择性地影响Sprague-Dawley雌鼠的可卡因、3、4-亚甲二氧基甲基amphetamine(MDMA)和尤梯隆奖赏作用及厌恶作用
Negar G Ardabili,Shira Tan,María Elisa Márquez de Prado Arrarás et al.
Negar G Ardabili et al.
Both the rewarding and aversive effects of a drug contribute to its abuse potential. One factor known to impact the balance of these effects is concurrent and serial polydrug use. A drug class for which such interactions are common is synth...
Nicotinic acid (NA) facilitates antidepressant effects through promoting neuro-protective transcriptome in the hippocampus [0.03%]
烟酸通过促进海马神经保护转录组来增强抗抑郁作用
Yikai Chen,Wen Ye,Wenxin Wang et al.
Yikai Chen et al.
Major depressive disorder (MDD) is characterized by anhedonia and cognitive deficits. In this study, we investigated the therapeutic effects of nicotinic acid (NA), a nicotinamide adenine dinucleotide+ (NAD+) precursor, in a mouse chronic r...
A systematic review of ketamine's anxiolytic potential in rodent behavioral models of anxiety and PTSD [0.03%]
氯胺酮在啮齿动物焦虑和创伤后应激障碍行为模型中的抗焦虑潜力系统评价
Alena Lemeshova,Kaya A Patel,Alexander J Bloom et al.
Alena Lemeshova et al.
Background: Ketamine, a nonselective NMDA-receptor antagonist, is an emerging therapeutic for treatment-resistant depression and could also be a promising treatment for anxiety and post-traumatic stress disorders. However...
Peripubertal PTSD-like stress in rats induces transient behavioral but lasting metabolic and inflammatory alterations: Limited fluoxetine efficacy [0.03%]
青春期前后类似 PTSD 的大鼠压力模型诱导了瞬时的行为但长期的代谢和炎症改变：氟西汀疗效有限
Larysa Bondarenko,Tetiana Karatsuba,Alla Voronina et al.
Larysa Bondarenko et al.
Post-traumatic stress disorder (PTSD) is increasingly recognized as a systemic disorder, with neuroendocrine, metabolic, and immune alterations accompanying its behavioral symptoms. While selective serotonin reuptake inhibitors such as fluo...