Catherine Arden
Catherine Arden
Autophagy is a highly conserved intracellular recycling pathway that serves to recycle damaged organelles/proteins or superfluous nutrients during times of nutritional stress to provide energy to maintain intracellular homeostasis and susta...
Ben Jones,Stephen R Bloom,Teresa Buenaventura et al.
Ben Jones et al.
Stimulation of insulin secretion by glucagon-like peptide-1 (GLP-1) and other gut-derived peptides is central to the incretin response to ingesting nutriments. Analogues of GLP-1, and inhibitors of its breakdown, have found widespread clini...
Targeted intestinal delivery of incretin secretagogues-towards new diabetes and obesity therapies [0.03%]
肠特异性分泌素药物递送——用于糖尿病和肥胖症的新疗法
Fiona M Gribble,Claire L Meek,Frank Reimann
Fiona M Gribble
A new strategy under development for the treatment of type 2 diabetes and obesity is to mimic some of the effects of bariatric surgery by delivering food-related stimuli to the distal gastrointestinal tract where they should enhance the rel...
Emily Brown,Daniel J Cuthbertson,John P Wilding
Emily Brown
Obesity is a major risk factor for type 2 diabetes and may complicate type 1 diabetes. In parallel with the global epidemic of obesity, the incidence of type 2 diabetes is increasing exponentially. To reverse these alarming trends, weight l...
Gina L C Yosten
Gina L C Yosten
Type 1 diabetes is characterized by selective loss of beta cells and insulin secretion, which significantly impact glucose homeostasis. However, this progressive disease is also associated with dysfunction of the alpha cell component of the...
Jens J Holst,Nicolai J Wewer Albrechtsen,Maria Buur Nordskov Gabe et al.
Jens J Holst et al.
Oxyntomodulin is a product of the glucagon precursor, proglucagon, produced and released from the endocrine L-cells of the gut after enzymatic processing by the precursor prohormone convertase 1/3. It corresponds to the proglucagon sequence...
Nicolai J Wewer Albrechtsen
Nicolai J Wewer Albrechtsen
Glucagon is a peptide hormone secreted from the pancreatic alpha cells in response to hypoglycemia but in some patients with type 2 diabetes a paradoxical hypersecretion results from the intake of glucose. In rodent, antagonizing the action...
R V Scott,S R Bloom
R V Scott
Globally, 13% of the world's adult population is obese, and more than 400 million people suffer from diabetes. These conditions are both associated with significant morbidity, mortality and financial cost. Therefore, finding new pharmacolog...
Emerging therapeutic potential for peptide YY for obesity-diabetes [0.03%]
肽类YY在肥胖和糖尿病治疗中的新兴潜力疗法功效研究
Ryan A Lafferty,Peter R Flatt,Nigel Irwin
Ryan A Lafferty
The vast majority of research to date on the gut hormone Peptide YY (PYY) has focused on appetite suppression and body weight regulation effects. These biological actions are believed to occur through interaction of PYY with hypothalamic Y2...
Biochemical properties and biological actions of obestatin and its relevence in type 2 diabetes [0.03%]
OBESTATIN的生化特性和生物学作用及其对2型糖尿病的意义
Brian D Green,David J Grieve
Brian D Green
Obestatin was initially discovered in rat stomach extract, and although it is principally produced in the gastric mucosa, it can be found throughout the gastrointestinal tract. This 23-amino acid C-terminally amidated peptide is derived fro...