Sulfakinin neuropeptides and their receptors in insects: Molecular signalling, physiological diversity, and pest management implications [0.03%]
昆虫硫激肽神经肽及其受体：分子信号、生理多样性及害虫管理意义
Samudrapu Sanjay Raj,Sanjay Kumar Sharma,Surjeet Kumar et al.
Samudrapu Sanjay Raj et al.
Sulfakinin (SK) peptides are the insect members of the ancient cholecystokinin (CCK)/gastrin superfamily, defined by a sulfated tyrosine near the C-terminus and a C-terminally amidated heptapeptide core, the modifications essential for rece...
Altered Gastrointestinal Function and Neurotensin Signaling in Experimental Type 2 Diabetes [0.03%]
实验性2型糖尿病患者的胃肠道功能和神经紧张素信号通路的改变
Sudenaz Öztürk,Hilal Kum,Şevval Sunuç et al.
Sudenaz Öztürk et al.
Background: Type 2 diabetes (T2D) often leads to diabetic gastroenteropathy characterized by gastrointestinal motility disorders, mucosal damage, and oxidative stress. Neurotensin (NT), a gastrointestinal peptide, modulat...
Identification of glicentin as a low-potency glucose-dependent insulinotropic polypeptide receptor agonist [0.03%]
格里辛汀是一种低效力的葡萄糖依赖性促胰岛素多肽受体激动剂 Identification of glicentin as a low-potency glucose-dependent insulinotropic polypeptide receptor agonist
Paula-Peace James-Okoro,Joss Field,Graeme Davies et al.
Paula-Peace James-Okoro et al.
The glucose-dependent insulinotropic polypeptide receptor (GIPR) is a class B1 G protein-coupled receptor (GPCR) that promotes glucose-dependent insulin secretion upon activation by GIP. Dual agonism of GIPR and glucagon-like peptide-1 rece...
Potential role of intelectin-1 in the regulation of feeding of goldfish (Carassius auratus) [0.03%]
Intelectin-1可能在调控金鱼（Carassius auratus）摄食行为中发挥作用
Heidi C Perry,Helene Volkoff
Heidi C Perry
Appetite regulation in vertebrates involves central neuropeptides and peripheral metabolic and endocrine signals that act together to maintain energy homeostasis. These include orexigenic (e.g., neuropeptide Y, orexin, ghrelin) and anorexig...
Cocaine- and amphetamine-regulated transcript (CART) peptides: neuroanatomical distribution and functional implications in the mammalian central nervous system [0.03%]
考可安和苯丙胺调节肽（CART）的神经解剖分布及其在哺乳动物中枢神经系统中的功能意义
Öykü Deniz Kanat,Esra Candar,Ibrahim Demircubuk et al.
Öykü Deniz Kanat et al.
The cocaine- and amphetamine-regulated transcript (CART) peptide is widely expressed throughout the mammalian central nervous system. CART was first identified during sequencing of a hypothalamic peptide whose biological function was unknow...
P1642-1, a novel pancreatic polypeptide analogue, ameliorates cognitive impairment in 5 ×FAD mice and is associated with enhanced PINK1/Parkin-related mitophagy [0.03%]
新型胰多肽类似物P1642-1改善5×FAD小鼠的认知障碍并增强线粒体自噬相关蛋白PINK1/Parkin的功能
Huan Zhang,Yinuo Wei,Enhua Liu et al.
Huan Zhang et al.
Currently, few pharmacological treatments are available for Alzheimer's disease (AD). However, gut-brain peptides, especially pancreatic polypeptide (PP) analogues, have shown promise. PP analogues have been reported to cross the blood-brai...
Structure-based rational design of high-affinity JAZF1 variants peptides to target the testicular orphan nuclear receptor 4 and pro-opiomelanocortin axis in Cushing's disease [0.03%]
基于结构的理性设计高亲和力JAZF1变体肽靶向库欣病中的睾丸孤儿核受体4和促黑素细胞皮质激素原轴
Wang Guoguo,Su Meng
Wang Guoguo
The regulation of pro-opiomelanocortin (Pomc) expression by the testicular orphan receptor 4 (TR4) constitutes a critical mechanism underlying the pathogenesis of Cushing's disease (CD). Although the endogenous repressor juxtaposed with ano...
[Gly2]-GLP-2(1-5)：An Ultra-Short GLP-2 Peptide for Intestinal Mucosal Protection in Inflammatory Bowel Disease [0.03%]
甘丙(GLP-2的类似物)-GLP-2(1-5):一种用于炎症性肠病肠道粘膜保护的超短GLP-2肽
Haiqing Liu,Weizhen Li,Chujun Ni et al.
Haiqing Liu et al.
Inflammatory bowel disease (IBD) is a disorder characterized by defective intestinal barrier function, aberrant over-apoptosis of intestinal epithelial cells, and constitutive activation of pro-inflammatory signaling pathways. Glucagon-like...
The Role of Kiss1 Neurons in Regulating Metabolism and Energy Balance [0.03%]
Kiss1神经元在调节代谢和能量平衡中的作用
Lingyu Sun,Ruidong Gao,Jing Chen
Lingyu Sun
Hypothalamic kisspeptin, encoded by the Kiss1 gene, serves as an important regulator of the reproductive axis and sexual maturation. Since reproductive physiology is tightly coupled to metabolic cues, metabolic status exerts significant inf...
Neuregulin 4 improves white adipose tissue inflammation in mice with polycystic ovary syndrome [0.03%]
神经调节素4可改善多囊卵巢综合征小鼠的白色脂肪组织炎症反应
Xi Wang,Meiqi Feng,Lingshan Hu et al.
Xi Wang et al.
Background: Neuregulin 4 (Nrg4), a secretory peptide predominantly derived from brown adipose tissue (BAT), has been verified to play roles in multiple metabolic disorders. Nevertheless, the role of Nrg4 in the pathogenes...